18 Ways to Beat Eczema, Acne and Psoriasis

18 Ways to Beat Eczema, Acne and Psoriasis

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18 Ways to Beat Eczema, Acne and Psoriasis

Eczema is known as a chronic dermatological condition that is characterized by skin rashes, dryness, crusting and flaking skin.  The word eczema is derived from the Greek word ekzein meaning “to boil out”; the Greek word ek means “out,” while the Greek word zema means “boiling.”  Research indicates that eczema is caused by chronic inflammation that affects the skin cells and causes scarring.

Psoriasis is an auto-immune disorder characterized by increased inflammatory attack against the skin cells.  Acne is associated with a chronic inflammatory attack against the sebaceous glands in the skin  Natural lifestyle strategies allow the body to modulate the immune system to reduce inflammation and beat eczema, psoriasis and acne.

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Is it Eczema, Acne or is it Psoriasis?

Eczema is a general diagnosis for any sort of superficial inflammatory process that primarily involves the epidermis (outer region of the skin).  This is usually marked early by redness, itching, minute papules and vesicles, weeping, oozing and crusting and later by scaling and flaking.  It is also commonly called atopic dermatitis or inflammation of the skin.

Acne develops as a result of blockages in the follicles with sebum and keratin. Sebum is produced by sebaceous glands. Enlargement of sebaceous glands and an increase in sebum production clogs the follicles. This increases the ‘acne bacteria’ (Propionibacterium Acnes) in the pores and that in turn causes inflammation.

The inflammation than wears down the protective skin barrier and makes the pore more susceptible to colonization by opportunistic bacteria, such as staphylococcus aureus.  This creates further inflammation and pus formation that we call a “pimple.”

In humans sebaceous glands occur over much of the body. They are usually associated with hair follicles and are particularly well developed in certain areas such as the scalp, face, upper back and chest. Hence you get more acne in these areas.

Psoriasis vulgaris (also known as chronic stationary psoriasis or plaque-like psoriasis) is the most common form and affects 85%–90% of people with psoriasis (1).  This typically appears as raised areas of inflamed skin covered with silvery-white scaly skin. These areas are called plaques and are most commonly found on the elbows, knees, scalp, and back

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Factors That Trigger Eczema:

Chronic inflammatory disorders such as eczema are characterized by a hyper responsive immune system.  Individuals with eczema often also suffer from other hyperinflammatory disorders such as asthma, allergies and hay fever.  Here are some of the major triggers of eczematic reactions:

1) Chemical Irritants:  This includes soaps, shampoos, cosmetics, dish washing and laundry detergents, disinfectants like chlorine and bleach.  This could also mean certain jewelry, electric blankets, excessive hand washing and certain clothing materials.  What irritates one individual is often different from what irritates someone else with this condition.

2)  Common Environmental Allergens:  Allergens are substances that can cause the immune system to overreact and create a physical manifestation.  Some of the most common allergens that can be causes of eczema include:

  • House dust mites
  • Pets (cats > dogs)
  • Pollens (seasonal)
  • Molds
  • Dandruff

3)  Very Hot or Very Cold Temperatures:  Major changes in weather are challenging for the body to adapt too and can cause hyper immune responses and increase the risk of an eczematic reaction.  In particular these things are known to trigger eczema:

  • Hot weather (greater than 80 deg F)
  • Cold weather (less than 30 deg F)
  • High and low humidity
  • Perspiration from exercise

4)  Mental & Emotional Stress:  Some people with eczema have worse symptoms when they are stressed. For others their eczema symptoms cause them to feel stressed.

5)  Food Sensitivities:  Certain foods can trigger an immune reaction that can aggregate eczema.  The most common food allergens and sensitivities include gluten, dairy products, corn, eggs, chocolate, nuts and soy products.

6)  Hormone Levels:  Hormones are chemicals produced by the body. They can cause a wide variety of effects. When the levels of certain hormones in the body increase or decrease some women can experience flare ups of their eczema.  Some women notice changes in eczema based around their menstrual cycle.

7)  Microbial Overgrowth:  Certain microbial species can aggravate eczema when they overpopulate.  This includes bacteria like E Coli and Staph, certain viruses and yeasts.

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The Allergic Triangle:

The Allergy Triad is the triangle of allergy-related conditions that many allergy sufferers have.   These include food or environmentally related allergies, asthma and eczema.  If you have one of these you are at much greater risk of having all three.  These conditions are related but they can also be found in isolation where an individual only deals with one of them.

Research has shown that 50-70% of children with severe atopic dermatitis go on to have asthma.  This is extremely high since the rate of asthma among the general population is only 9% of children and 7% of adults (1, 2).

Scientists have found a compound called TSLP (thymic stromal lymphopoietin) as a possible link between eczema and asthma.  When skin is damaged it secretes TSLP as an alarm signal to the rest of the body that the skin has been damaged.  This is an important survival instinct as the skin is the first line of defense from microscopic invaders and a breakdown in the skin integrity could lead to a life-threatening infection.

TSLP is no ordinary compound, it is an interleukin-7 cytokine that is capable of creating a powerful Th2 mediated immune response (3, 4).  TSLP travel throughout the body via the bloodstream and has an affinity for the lungs where it can trigger the hypersensitive characteristics of asthma.

The Genetic Aspect of Eczema:

Genetics play a role in why one individual will develop eczema when their body is stressed while another individual will not.  Several genetic abnormalities have been noted in individuals with eczema and atopic dermatitis (AD).  In particular, variants have been found in the FLG gene (which encodes the epidermal barrier protein filaggrin) (5).

Filaggrin plays a critical role in the skin barrier integrity.  It is a vital epidermal protein that is needed to develop corneocytes and for the generation of intracellular metabolites that modulate the hydration and pH of the skin (6).

Research shows that 10% of the westernized population and 50% of individuals with eczema have mutations in the FLG gene.  Other skin-related genes such as SPINK5/LEKT1 may also play a role in the pathogenesis of eczema (7, 8)

Although genetic polymorphisms predispose one to developing a certain health condition, epigenetics, or how the environment impacts our genes plays a larger role in the development of a chronic condition such as eczema (9, 10).

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Immune Modulation:

Chronic inflammatory disorders such as excema, acne and psoriasis are characterized by a hyper responsive immune system.  There are several key epigenetic factors that must be addressed to regulate and better coordinate the immune system.

1.  Poor Blood Sugar Stability:  Blood sugar imbalances cause immune dysfunction and malcoordination.  Stable blood sugar is critical for a healthy immune response.

2.  Low Vitamin D Levels:  Individuals with low vitamin D3 levels (below 40 ng/ml) are at significant risk for developing chronic inflammation and allergy-like conditions (10).

3.   Gut Dysbiosis:  Poor microbial balance in the gut microbiome leads to leaky gut syndrome and chronic inflammation (11).  The gut must be addressed in order to get well.

4.   Mitochondrial Dysfunction:  The mitochondria are the energy producing organelles in each cell of the body.  They are extremely key in the bodies ability to handle oxidative stress.  Dysfunction in the mitochondria leads to increased free radical and oxidative stress which creates immune alterations.

5.  Low Glutathione Levels:  Glutathione is the major anti-oxidant within every cell of the body.  It is critical for white blood cell (WBC) function as the WBC’s encounter tremendous amounts of free radical and oxidative stress every second of the day.  Low glutathione leads to chronic inflammation and often to auto-immunity (12).

6.  Poor Omega 6:3 ratio:  The average person has significantly more omega 6 fats than omega 3 fats.  The increased omega 6 stimulate the release of pro-inflammatory mediating prostaglandin molecules.  This is a key factor in the development of chronic inflammation and skin related disorders (13).

7. Upper Cervical Subluxation:  The bottom of the skull (occiput) and the first bone (atlas) play a significant role in the coordination patterns of the brain and immune system.  Dysfunction at this joint torques and compresses the top of the spinal cord and increases inflammatory activity in the body (14).

8.  Environmental Toxins:  Exposure to high levels of infectious microbes, environmental chemicals such as plasticizers, pesticides, herbicides, personal care products, heavy metals and biotoxins such as mold wear down the bodies glutathione levels, alter the gut microflora and increase inflammatory activity in the body (15, 16, 17).

9.  High Stress and Poor Breathing Habits:  High mental and emotional stress increases stress hormone production which induces inflammatory activity within the body.  Short and shallow breathing habits can simulate chronic mental and emotional stressors on the physiological level (18).

10.  Lack of Sleep:   Poor sleep promotes immune dysfunction and increased inflammation.  Good sleeping habits and optimal melatonin secretion reduce inflammation and promote improved tissue healing (19).

11.  Methylation:  Methylation is a key process that protects DNA, turns on and off genetic traits and helps to detoxify environmental chemicals.  Many individuals have certain genetic polymorphisms that limit their ability to appropriately methylate. Methylation plays a very important role in T cell function and poor methylation status is associated with the development of auto-immunity (20).

12.  EMF Exposure:  Electromagnetic frequency exposure has been shown to alter the function of the immune system and increase one’s susceptability to developing an auto-immune condition (21)

I will touch on a few of these key areas and how they relate to Rheumatoid arthritis in this article.

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Gut-Skin Connection:

Research shows that there is a clear relationship between gut problems and skin disorders such as acne, eczema and rosacea.  A 2008 study reported that small intestinal bacterial overgrowth (SIBO), was 10 times more prevalent in individuals suffering with acne and rosacea than in groups without these skin disorders.  The study also showed that the eradication of the SIBO created an almost complete regression of symptoms (22).

One study involving over 13,000 adolescents showed that those with acne were more likely to experience gastrointestinal symptoms such as constipation, halitosis, and gastric reflux. In particular, abdominal bloating was 37% more likely to be associated with acne and other skin related disorders such as eczema and rosacea (23).

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Research has shown that as many as 40% of those with acne have hypochlorhydria (24).  When one has less than adequate stomach acid the body is unable to effectively disinfect the food it consumes. This increases the microbial load on the body which stresses the immune system.

In addition, the lack of stomach acid sets the stage for migration of bacteria from the colon towards the distal portions of the small intestine, as well as an alteration of normal intestinal microflora (25).

Another study with over 80 patients showed that those with acne had higher reactivity to lipopolysaccharide (LPS) endotoxins in the blood.  LPS is the microbial waste from gram negative bacteria such as E Coli.  The healthy control group did not react to the LPS, but 65% of the acne patients had a reaction (26).

Leaky Gut = Leaky Skin:

The main goal of the skin is to act as a defense system to protect the body from physical, chemical and microbial stressors.   Inflammation along the gut lining along with a genetic polymorphism can break down the protective epidermal barrier of the skin.  This process decreases the antimicrobial proteins produced in the skin and can lead to skin infections or hyperinflammatory processes (27).

The gut flora has profound influence on the structural components of the skin including the fatty acid profiles and sebum production.  Altered fatty acid and sebum production leads to increased inflammation and possible infection of the skin cells and increases the development of acne, rosacea and eczema.

When the skin is irritated a neuropeptide called substance P is produced that triggers an inflammatory response.  Individuals with dysbiosis or abnormal bacterial balance, have increased substance P production.  Substance P increases sebum production along with mast cell degranulation and a hyperinflammatory response.

Research has shown that oral consumption of probiotics reduced the vasodilation, edema, mast cell degranulation and TNF-alpha release induced by substance P, compared to the control group (28).

Most people think that you have to apply something topically in order to effect the skin, but numerous articles discuss the importance of oral probiotic consumption and reduce skin related inflammation, reinforces skin barrier function, decreases skin sensitivity and modulates the skin immune system leading to the preservation of skin homeostasis (29).

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Food Sensitivities:

Gut dysbiosis and intestinal permeability create a heightened immune response to specific dietary agents.  Research has shown that individuals struggling with eczema, acne, rosacea, psoriasis and other inflammatory disorders of the skin are often aggravated by certain foods (30, 31).

The most common food sensitivities include wheat and gluten, dairy products, soy, corn, eggs, nuts, chocolate and sugar.  Additionally, genetically modified foods are harmful to the gut lining and can increase skin related inflammation.

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Transglutaminase AutoImmunity: 

There are specific enzymes found throughout the body called transglutaminases that function to bind proteins together.  They are key to the digestion of wheat and gluten.  When someone has a food sensitivity to gluten they can often develop antibody’s to transglutaminase enzymes.

Transglutaminase-2 (TG-2) is found in the intestinal lining and anti-bodies to TG-2 are a marker for celiac disease.  Transglutaminase-3 (TG-3) are found in the skin and anti-bodies can lead to chronic acne, eczema and dermatitis.  Transglutaminase-6 (TG-6) is found throughout the central nervous system and antibody formation leads to neurological disorders.

Transglutaminase enzymes are also used by the food industry to tenderize meat to hold processed meats together in specific shapes.  Individuals with transglutaminase reactivity would have significant reactions when they consume these processed meats as well.

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Vitamin D and Phototherapy:

Vitamin D has been shown to reduce inflammation and lower the risk of developing eczema, acne, seborrheic  dermatitis and psoriasis.  A 2011 study looked at children with mild, moderate and severe eczema and a direct relationship this vitamin D status and severity of eczema.  The children with the most severe eczema had the lowest levels of 25 (OH) vitamin D3.

Vitamin D has been shown to be active in the nuclei of the epidermis tissue where it enhances keratinocyte differentation (32).  It is able to modulate skin cell growth in such a way as to favor keratinocyte proliferation in normal tissue and inhibit the proliferation in psoriatic tissue (which is marked by excessive proliferation) (33).

Vitamin D also reduces inflammatory cytokine production in the dermal and epidermal tissue and strengthens the permeablity barrier of the epidermis.  This reduces the occurence of infection in the skin and makes it resist stress more effectively (34, 35).

Many individuals have found success using phototherapy to reduce symptoms of eczema and psoriasis.  Phototherapy is simply narrowband ultraviolet B light that is emitted from a special machine at 311-312 nm.  This maximized UVB expression and reduces the more harmful UVA frequencies that are more damaging to the skin.

Phototherapy works by (36)

  • Reducing itching and skin proliferation
  • Profound anti-inflammatory effects
  • Increasing vitamin D production
  • Increases immune regulation and bacteria-fighting systems in the skin

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Glutathione Levels and Skin Disorders:

Glutathione is the bodies master anti-oxidant it is one of the major modulators of the immune system.  A 1982 study looked at 61 healthy subjects and 506 patients with various skin disorders. Depressed glutathione levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis (37).

Some studies have demonstrated that individuals with eczema, psoriasis, vitilago and other skin disorders have genetic polymorphisms in their glutathione production pathways (38, 39).  This would indicate higher glutathione needs through dietary precursors and nutritional supplementation.  Studies have demonstrated improvement in these conditions with the addition of glutathione precursors via diet and supplementation (40).

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Omega 3 Fatty Acids and Skin Health:

The levels of omega 6:omega 3 are critical for the development and regulation of epidermal barrier integrity and sebum formation.  Individuals with higher omega 6 levels had more inflammatory cytokines in the skin tissue, a weakened epidermal barrier and increased sebum production (41, 42).

One type of omega 6 fat, gamma linoleic acid, happens to be very beneficial for individuals with eczema and other skin disorders.  Additionally, supplementing with long-chain omega 3 fatty acids EPA and DHA help to reduce inflammatory cytokines in the skin and strengthen epidermal barrier function (43, 44).

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Zinc & Selenium and Skin Health

Zinc and selenium deficiencies are rarely known but rather large and widespread issues that promote inflammation and increased risk of inflammatory disorders.  Zinc and selenium deficient diets are associated with increased inflammatory cytokines in the skin and reduce epidermal barrier function which predisposes one to developing eczema and other skin disorders (45, 46).

Zinc deficiency is a common issue with infants suffering from eczema (47).  Because breast milk is naturally low in zinc, it is important for mothers to supplement and consume a high zinc diet during pregnancy to reduce risk of eczema in infancy.

When treating eczema with zinc and selenium, it is best to take chelated supplements such as zinc glycinate and selenomethionine. In chelated forms the zinc and selenium are bound to an amino acid that help transport it through the gastrointestinal tract.   Free selenium and zinc are potentially toxic to humans.

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Low Histamine Considerations:

Histamines are important neurotransmitter and immune messenger molecules. They are involved in processes involving hydrochloric acid secretion for digestion, triaging water reserves to key areas of the body and the inflammatory response.

Histamine only becomes a problem when we have metabolic disturbances that do not allow us to effectively metabolize histamine properly.  A new study recently found that mast cells (which release histamine molecules) are a key culprit in causing eczema (also known as atopic dermatitis).

The researchers also revealed that a protein known as STAT5, plays an important role in the equation by triggering major mast cell increases in some.  Mast cells release histamine and when their activity is increased can cause a major histamine reaction leading to inflammation in various tissues of the body (48).

Mast cells are present in most tissues characteristically surrounding blood vessels and nerves, and are especially prominent near the boundaries between the outside world and the internal world. This includes the skin and the mucosa of the lungs, intestines, mouth and nose.

One study found that an individual showed significant improvement in atopic dermatitis symptoms using a balanced low-histamine dietary regimen (49).  I use a nutrient dense low-histamine diet for a period of time to help my clients with eczema, psoriasis, hives and other skin disorders.  This is especially important if I see that they have seasonal allergies, headaches and other histamine related symptoms.
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18 Ways to Beat Eczema, Acne & Psoriasis:

Here are the best action steps to get started with on your journey to prevent and/or beat eczema, psoriasis, acne and other skin disorders.  You should always consult with your physician before stopping or changing medications or taking on new health strategies.

Additionally, you should be working with a functional health practitioner to help guide you through these strategies.  This is not an exhaustive list and there are other natural therapeutic strategies that I and functional health practitioners will utilize to help individuals with eczema, psoriasis, acne and other skin disorders.

1)  Change Your Diet:  Follow an Anti-Inflammatory nutrition plan here and consider the auto-immune diet and/or the low-histamine diet, both of which you can find here

You can also do a biofeedback test to determine what foods are causing stress in your system and an elimination diet to test how you are responding to eliminating certain foods for periods of time.  Use high quality collagen protein and bone broths to help heal the gut lining and improve the strength and integrity of the skin barrier.

2)  Reduce Stress:  Find ways to reduce stressful activities and enjoy more peace and calm.  Learn to thrive under stress by reading this article here

3)  Improve Your Sleep:  Sleeping a high quality 8-9 hours each night is key to healing and reducing inflammation.  Follow the steps in this article to improve your sleep.

4)  Consume Zinc and Selenium rich Foods:  This includes healthy organic, pasture-raised meat and wild-caught fish.  It includes pumpkin seeds, brazil nuts and green vegetables.

5)  Get High Quality Vitamin A and Vitamin E:  Fat soluble vitamin A & E are super key for healthy skin and reduced inflammation in the epidermis.  In particular, the fat soluble retinol version of vitamin A is significantly better than the water soluble beta carotene found in carrots.  The best foods for retinol and vitamin E include grass-fed butter or ghee, avocados, cod liver oil and organ meats from pasture-raised animals.  Be sure to consume ample amounts of these super foods to improve your skin health.

6)  Focus on Deep Breathing:  Improving your posture, seeing a high quality chiropractor and optimizing your breathing patterns is highly recommended to reduce stress and inflammation.  Follow these tips here to improve your breathing patterns.

7)  Use Anti-Oxidant Rich Herbs:  Add turmeric, ginger, oregano, garlic, basil, thyme and rosemary to as many dishes as possible and drink organic herbal teas on a regular basis.

8)  Ground Your Body:  In our society we are surrounded by toxic electromagnetic frequency’s (EMF’s).  These EMF’s increase stress within our body and alter neurotransmitter function.  By going outside daily and walking barefoot on grass, dirt or sand you absorb natural EMF’s from the ground that balance your electrical rhythms.  Follow the steps in this article here.

9)  Supplement With Omega 3’s:  Omega 3 fatty acids and in particular the long chain variety EPA and DHA and the omega 6 fat GLA are critical for improving epidermal function and reducing skin related inflammation. Consume grass-fed meat, grass-fed butter, wild-caught fish and spirulina to get it in your diet.

It is also advisable to supplement with 1-2 grams daily of EPA/DHA along with 150-200 mg of GLA.  Clinically, I use ProEFA to boost up omega 3’s.

10)  Juice Your Veggies:    Juicing is one of the best ways to get high quality anti-oxidants and powerful phytonutrients into your system.  Here is my article on Best Juicing strategies.

11)  Intermittent Fasting:  Going 16 hours between dinner and breakfast is one of the best ways to reduce oxidative stress and inflammation and repair the gut lining.  Consume your meals in an 8 hour window such as 11am – 7pm.  Read this article for more info on fasting.

12) Optimize Your Vitamin D:  Be sure to increase your vitamin D through good amounts of regular sun exposure and/or taking a high quality vitamin D3/K2 supplement.  Consider using phototherapy through safe tanning bed exposure if you are unable to get healthy sun exposure.

13)  Practice Oil Pulling:  Oil pulling helps to reduce the microbial load in your mouth.  This takes stress off of the immune system and reduces inflammation levels throughout the body.  Read more about oil pulling here and practice this 2x daily.

14)  Get a Home Water Filtration System:  Very important to avoid the chloride, fluoride, pesticides, heavy metals, etc. that are found in tap water.  These environmental toxins destroy helathy microflora and weaken skin epidermal barriers.  Use a good whole home water filtration system as discussed in this article here

15)   Use Essential Oils:  The anti-oxidant content and aromatherapy benefits of essential oils help to improve oxygenation and reduce the harmful effects of oxidative stress throughout the body.  Some of my favorites include lavendar, peppermint, chamomile and sweet orange among others.

Put a drop on your hands and mix together with a carrier oil like coconut or olive oil and apply to skin.  These nourish the skin and help to optimize the skin’s microbiome.

16) Improve Your Gut Motility:  Improving bowel movement frequency and consistency is a key detoxification concept.  Consuming an anti-inflammatory diet with good fiber sources such as  chia seed and flax seed, using bone broths, fermented foods, collagen proteins and probiotics will improve bowel motility.

17)  Apple Cider Vinegar and Coconut Oil:  Many individuals with eczema, acne, rosacea and psoriasis often see improvement by applying diluted apple cider vinegar (ACV), approximately 1 tbsp in 2 oz of water and coconut oil to their skin.  The ACV and coconut help to reduce inflammation and nourish a healthy skin microbiome.

Apply ACV and let dry (15 minutes or so) and coconut oil and let dry.  Try to do this every 3-4 hours if possible.  Even if not, doing it once or twice daily will be of benefit.

18)  Heal Leaky Gut Syndrome:  Individuals with eczema, psoriasis and acne often have SIBO and serious cases of intestinal permeability and gut dysbiosis.  Using an advanced gut healing protocol is often necessary to help these individuals get well.

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Sources For This Article Include:

1. Palfreeman AC, McNamee KE, McCann FE. New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast. Drug Design, Development and Therapy. 2013;7:201-210.
2. Atopic Dermatitis: Global Epidemiology and Risk Factors Link Here
3. Wang WL, Li HY, Zhang MS, Gao PS, He SH, Zheng T, Zhu Z, Zhou LF. Thymic stromal lymphopoietin: a promising therapeutic target for allergic diseases. Int Arch Allergy Immunol. 2013;160(1):18-26. PMID: 22948028
4. Ito T, Liu YJ, Arima K. Cellular and molecular mechanisms of TSLP function in human allergic disorders–TSLP programs the “Th2 code” in dendritic cells. Allergol Int. 2012 Mar;61(1):35-43. PMID: 22189594
5. Osawa R, Akiyama M, Shimizu H. Filaggrin gene defects and the risk of developing allergic disorders. Allergol Int. 2011 Mar;60(1):1-9. PMID: 21173567
6. Levin J, Friedlander SF, Del Rosso JQ. Atopic Dermatitis and the Stratum Corneum: Part 1: The Role of Filaggrin in the Stratum Corneum Barrier and Atopic Skin. The Journal of Clinical and Aesthetic Dermatology. 2013;6(10):16-22.
7. Kato A, Fukai K, Oiso N, Hosomi N, Murakami T, Ishii M. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol. 2003 Apr;148(4):665-9. PMID: 12752122
8. Zhao LP, Di Z, Zhang L, Wang L, Ma L, Lv Y, Hong Y, Wei H, Chen HD, Gao XH. Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China. J Eur Acad Dermatol Venereol. 2012 May;26(5):572-7. PMID: 21585560
9. Renaudineau Y, Youinou P. Epigenetics and autoimmunity, with special emphasis on methylation. Keio J Med. 2011;60(1):10-6. PMID: 21460598
10. Tezza G, Mazzei F, Boner A. Epigenetics of allergy. Early Hum Dev. 2013 Jun;89 Suppl 1:S20-1. PMID: 23809342
11. Proal AD, Albert PJ, Marshall TG. The human microbiome and autoimmunity. Curr Opin Rheumatol. 2013 Mar;25(2):234-40. PMID: 23370376
12. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. PMID: 19393193
13. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79. PMID: 12442909
14. Upper Cervical Vertebral Subluxation in Multiple Sclerosis Subjects with Chronic Cerebrospinal Venous Insufficiency: A Pilot Study Link Here
15. Bigazzi PE. Autoimmunity and heavy metals. Lupus. 1994 Dec;3(6):449-53. PMID: 7704000
16. Hess EV. Environmental chemicals and autoimmune disease: cause and effect. Toxicology. 2002 Dec 27;181-182:65-70. PMID: 12505286
17. Ercolini AM, Miller SD. The role of infections in autoimmune disease. Clinical and Experimental Immunology. 2009;155(1):1-15.
18. Stojanovich L, Marisavljevich D. Stress as a trigger of autoimmune disease. Autoimmun Rev. 2008 Jan;7(3):209-13. PMID: 18190880
19. Palma BD, Gabriel A Jr, Colugnati FA, Tufik S. Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol. PMID: 16809486
20. Richardson B. DNA methylation and autoimmune disease. Clin Immunol. 2003 Oct;109(1):72-9. PMID: 14585278
21. Electromagnetic fields and autoimmune diseases Link Here
22. Parodi A, Paolino S, Greco A, Drago F, Mansi C, Rebora A, Parodi A, Savarino V. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008 Jul;6(7):759-64. PMID: 18456568
23. Zhang H, Liao W, Chao W, Chen Q, Zeng H, Wu C, Wu S, Ho HI. Risk factors for sebaceous gland diseases and their relationship to gastrointestinal dysfunction in Han adolescents. J Dermatol. 2008 Sep;35(9):555-61. PMID: 18837699
24. Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014 Jun 1;5(2):185-99. PMID: 23886975
25. Dukowicz AC, Lacy BE, Levine GM. Small Intestinal Bacterial Overgrowth: A Comprehensive Review. Gastroenterology & Hepatology. 2007;3(2):112-122.
26. Juhlin L, Michaëlsson G. Fibrin microclot formation in patients with acne. Acta Derm Venereol. 1983;63(6):538-40. PMID: 6198846
27. Slominski A. A nervous breakdown in the skin: stress and the epidermal barrier. The Journal of Clinical Investigation. 2007;117(11):3166-3169.
28. Gueniche A, Benyacoub J, Philippe D, Bastien P, Kusy N, Breton L, Blum S, Castiel-Higounenc I. Lactobacillus paracasei CNCM I-2116 (ST11) inhibits substance P-induced skin inflammation and accelerates skin barrier function recovery in vitro. Eur J Dermatol. 2010 Nov-Dec;20(6):731-7. PMID: 20965806
29. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel-Higounenc I, Guéniche A. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defences. Benef Microbes. 2014 Jun 1;5(2):129-36. PMID: 24322880
30. Eczema: Can eliminating particular foods help? Link Here
31. Atopic Dermatitis and Disease Severity Are the Main Risk Factors for Food Sensitization in Exclusively Breastfed Infants Link Here
32. Searing DA, Leung DY. Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases. Immunology and allergy clinics of North America. 2010;30(3):397-409.
33. Searing DA, Leung DY. Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases. Immunology and allergy clinics of North America. 2010;30(3):397-409.
34. Searing DA, Leung DY. Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases. Immunology and allergy clinics of North America. 2010;30(3):397-409
35. Searing DA, Leung DY. Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases. Immunology and allergy clinics of North America. 2010;30(3):397-409.
36. Rácz E, Prens EP, Kurek D, Kant M, de Ridder D, Mourits S, Baerveldt EM, Ozgur Z, van IJcken WF, Laman JD, Staal FJ, van der Fits L. Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways. J Invest Dermatol. 2011 Jul;131(7):1547-58. PMID: 21412260
37. Juhlin L, Edqvist LE, Ekman LG, Ljunghall K, Olsson M. Blood glutathione-peroxidase levels in skin diseases: effect of selenium and vitamin E treatment. Acta Derm Venereol. 1982;62(3):211-4. PMID: 6179360
38. Cho HR, Uhm YK, Kim HJ, Ban JY, Chung JH, Yim SV, Choi BK, Lee MH. Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population. Int J Immunogenet. 2011 Apr;38(2):145-50. PMID: 21176116
39. Liu L, Li C, Gao J, Li K, Gao L, Gao T. Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population. J Invest Dermatol. 2009 Nov;129(11):2646-52. PMID: 19571817
40. Prussick R, Prussick L, Gutman J. Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study. The Journal of Clinical and Aesthetic Dermatology. 2013;6(10):23-26.
41. Miyake Y, Tanaka K, Sasaki S, Arakawa M. Polyunsaturated fatty acid intake and prevalence of eczema and rhinoconjunctivitis in Japanese children: the Ryukyus Child Health Study. BMC Public Health. 2011 May 21;11:358. PMID: 21599987
42. Essential fatty acid metabolism and its modification in atopic eczema Link Here
43. Miyake Y, Sasaki S, Tanaka K, Ohya Y, Matsunaga I, Yoshida T, Hirota Y, Oda H. Relationship between dietary fat and fish intake and the prevalence of atopic eczema in pregnant Japanese females: baseline data from the Osaka Maternal and Child Health Study. Asia Pac J Clin Nutr. 2008;17(4):612-9. PMID: 19114399
44. Horrobin DF. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr. 2000 Jan;71(1 Suppl):367S-72S. PMID: 10617999
45. Takahashi H, Nakazawa M, Takahashi K, Aihara M, Minami M, Hirasawa T, Ikezawa Z. Effects of zinc deficient diet on development of atopic dermatitis-like eruptions in DS-Nh mice. J Dermatol Sci. 2008 Apr;50(1):31-9. PMID: 18248795
46. Planková A, Mikus P, Havránek E. Determination of selenium in clinical plasma samples related to atopic dermatitis study by chronopotentiometric stripping method. Pharmazie. 2010 May;65(5):327-30. PMID: 20503922
47. Kienast A, Roth B, Bossier C, Hojabri C, Hoeger PH. Zinc-deficiency dermatitis in breast-fed infants. Eur J Pediatr. 2007 Mar;166(3):189-94. PMID: 16960696
48. Ando T, Xiao W, Gao P, et al. Critical Role for Mast Cell Stat5 Activity in Skin Inflammation. Cell reports. 2014;6(2):366-376.
49. Chung BY, Cho SI, Ahn IS, et al. Treatment of Atopic Dermatitis with a Low-histamine Diet. Annals of Dermatology. 2011;23(Suppl 1):S91-S95.

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