Turmeric Fights Against Chronic Disease:
The orange Asian herb turmeric has been traditionally used for centuries by Ayurveda and Chinese medicine. Curcumin is the most powerful active anti-inflammatory compound within turmeric. Curcumin has been shown to be a powerful suppressor of chronic inflammatory mediated disease processes (1).
Many Asian cultures use turmeric in nearly every meal. They rave of its anti-aging and medicinal benefits. Western medicine has just begun to research it its components at a very deep level to better understand turmeric’s remarkable health properties. Over 570 studies have appeared in the mainstream literature demonstrating curcumin’s cancer protective effects (2).
Curcumin and Blood Sugar Stability:
Curcuminoid polyphenols are the primary anti-oxidant in turmeric root. Curcumin is the principle curcuminoid and it is responsible for the majority of health benefits attributed to turmeric. The other curcuminoids include desmthoxycurcumin and bis-desmethoxycurcumin.
Blood sugar imbalances and insulin resistance are huge factors that promote inflammatory conditions in the body. Elevated blood sugar creates hazardous glucose cross linked proteins called Advanced Glycolytic Enzymes (AGE’s). These AGE’s damage cell membranes, vital enzyme systems and perpetuate inflammatory conditions throughout the body.
Curcumin modulates blood sugar and improves insulin receptor function by improving its binding capacity to sugar. Curcumin activates PPAR (peroxisome proliferator-activator receptor) which is a group of key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream.
Curcumin also reduces the activity of specific liver enzymes that release sugar into the bloodstream while activating enzymes that store sugar as glycogen. Research on type 2 diabetes patients resulted in blood glucose stabilization and lowered triglyceride levels in the group that consumed curcumin (3).
Curcumin as an Anti-oxidant:
Turmeric is the 8th highest anti-oxidant rich food on the planet with an Oxygen Radical Absorbency Capacity (ORAC) of 127,068 (4). The curcuminoids boost levels of the bodies most potent anti-oxidants including glutathione, superoxide dismutase and catalase. These molecules are critical for the body to limit oxidative stress related damage to the vital organ systems.
Curcumin has been shown to reduce inflammatory mediating prostaglandins, cytokines and other molecules such as interleukin 6, Nuclear Factor Kappa Beta (NF-kb) and tumor necrosis factor-alpha (TNF – alpha) (5, 6). With a high enough dosage this has the ability to pull the body out of a strong inflammatory cascade and reset anti-inflammatory behavior at the cellular level.
Curcumin and Cancer:
Research done at the Life Extension Foundation found that curcuminoids target ten factors involved in cancer development (7). This includes chronic inflammation, DNA damage and disruption of cell signaling pathways. Curcumin supplementation was shown to target destruction of cancer cell mitochondria, disrupt the cancer cell cycle and arrest stem cell development that facilitates further cancer cell formation.
There are hundreds of other studies that have shown that curcumin turns on natural apoptotic (cell suicide) switches in cancer cells (8). They also reduce inflammatory prostaglandins that promote cancer cell growth. A study out of China showed that curcumin was able to induce apoptosis within triple negative breast cancer (TNBC) cells (9). TNBC is a type of cancer that defies conventional chemotherapy and radiation.
Best Dosages of Curcumin:
For optimal curcumin absorption it is necessary to combine the turmeric with good fats such as coconut oil or milk or olive oil. You will also want to add a dash of black pepper for the piperine molecule that enhances curcumin uptake.
For individuals with chronic inflammatory diseases such as cancer it is recommended to supplement with high dose curcumin. Find one that is made with piperine in an enteric coating that protects the nutrient from stomach acid for optimal absorption.
There hasn’t been an official dosage that has been established by the scientific literature. However, studies involving human patients with cancer found that curcumin doses of 3.6 grams or more daily had the best effect (10).
Curcumin regulates tumor suppressor pathways and triggers mitochondrial mediated death in the cancer tissue. Curcumin is anti-angiogenic which means that it shuts down the ability of cancer cells to develop extra blood supply that these cells use to fuel on. This effect makes cancer cells more vulnerable to pharmacological treatments such as chemotherapy and other cancer control drugs.
I highly recommend using turmeric on various foods. I will put it on my meat (chicken, bison, grass-fed beef, lamb, eggs, etc) after I cook it (not before because I don;t want to damage these precious anti-oxidants). I simply grill up the meat on a pan in a large amount of coconut oil. After it is cooked, I add a lot of turmeric (usually a few tsps) and smother it in the oils around the meat and flip the meat around so that the oils collect the turmeric and it stays attached to the meat.
I also add in some black pepper as curcuminoid anti-oxidants are absorbed and utilized more effectively with the use of good fats like coconut oil, olive oil or butter and black pepper.
The supplement I recommend for curcumin is Nrf2 Power here that also contains 3 other powerful gene regulators in ECGC (Green Tea Extract), Sulfuraphane and Pterostilbene.
Sources For This Article Include:
- Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014 Nov 1;32(6):1053-64. PMID: 24793420
- Linnewiel-Hermoni K, Khanin M, Danilenko M, Zango G, Amosi Y, Levy J, Sharoni Y. The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity. Arch Biochem Biophys. 2015 Feb 21. PMID: 25711533
- Neerati P, Devde R, Gangi AK. Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytother Res. 2014 Dec;28(12):1796-800. PMID: 25044423
- Super Foodly: Spices Turmeric, Ground Link Here
- Lee KH, Abas F, Alitheen NB, Shaari K, Lajis NH, Ahmad S. A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages. Molecules. 2011 Nov 23;16(11):9728-38. PMID: 22113581
- Seyedzadeh MH, Safari Z, Zare A, Gholizadeh Navashenaq J, Razavi SA, Kardar GA, Khorramizadeh MR. Study of curcumin immunomodulatory effects on reactive astrocyte cell function. Int Immunopharmacol. 2014 Sep;22(1):230-5. PMID: 24998635
- Life Extension: How Curcumin Protects Against Cancer Link Here
- Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-Terminal Kinase (JNK)-Dependent Manner. J Biol Chem. 2015 Apr 3. PMID: 25839235
- Chen WC, Lai YA, Lin YC, Ma JW, Huang LF, Yang NS, Ho CT, Kuo SC, Way TD. Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells. J Agric Food Chem. 2013 Dec 4;61(48):11817-24. PMID: 24236784
- Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484