Intermittent Fasting Boosts Your Immune System -

Intermittent Fasting Boosts Your Immune System

Intermittent Fasting Immune Cover

Fasting Boosts Your Immune System:

Our ancient ancestors grew up in a world of stress and scarcity. Food was often not available and intermittent fasting was common. This form of life left a genetic blueprint with key information pertaining to our health and wellbeing.  Intermittent fasting reduces free radical damage, regulates inflammatory conditions in the body and starves off cancer cell formation.

In nature, when animals get sick they stop eating and instead focus on resting.  This is a primal instinct to reduce stress on their internal system so there body can fight off infection.   This natural mechanism allows the animal to concentrate all their internal energy systems towards immunity.  Humans are the only species that often look for more food during times of illness.

Energy Conservation in the Body:

The body has a certain amount of available energy that it diverts into important function such as digestion, physical movement (kinetics), immunity, cognition, etc.  The continual need to digest food diverts energy away from these other factors while fasting conserves energy for use with these other systems.  In fact, the digestive process diverts huge amounts of blood and is considered energy expensive.

When we eat food the immune system gets activated to increase inflammatory conditions to ward off any unwanted microorganisms within the food.  This happens whether the food is raw or cooked as nothing is truly sterile.  When the immune system activates in order to attack newly ingested pathogens it is using up its energy reserves that could be used for other activities.  Fasting frees these white blood cells up to destroy dormant infections and other problematic areas.


Fasting Increases Immune Regulation

The practice of fasting allows the body to put more energy and focus into the process of effective immune regulation.  Fasting while drinking water and cleansing beverages flushes out the digestive system and reduces the number of natural microorganisms in the gut.  The microorganism count is typically regulated by the immune system.  So this allows the immune system to divert energy to other more important areas.

Intermittent fasting is a terrific regulator of the immune system as it controls the amount of inflammatory cytokines that are released in the body.  Two major cytokines Interleukin-6 and Tumor Necrosis Factor Alpha promote an inflammatory response in the body.  Studies have shown that fasting reduces the release of these inflammatory mediators (1, 2, 3).  The immune system modulation that intermittent fasting provides may also be helpful if you have moderate to severe allergies (4).


Autophagy to Protect the Body:

Fasting also stimulates the process of autophagy, where the body breaks down old, damaged cells and abnormally developing cells to recycle for energy.  The process of autophagy is part of the innate immune system and utilizes pattern recognition receptors to identify viral cell invaders.

Intermittent fasting stimulates autophagy processes which restrict viral infections and the replication of intracellular parasites.  This catabolic process helps the body rid itself of intracellar pathogens as well as abnormal cancer cell development.  It is also important in protecting the brain and tissue cells from abnormal growths, toxicity and chronic inflammation (5).


Intermittent Fasting and Auto-Immunity

Individuals with auto-immune diseases such as systemic lupus, rheumatoid arthritis, colitis and Crohn’s disease have seen a tremendous improvement in symptoms with the incorporation of intermittent fasting (6).  This process reduces the hyper inflammatory processes these individuals undergo and allow for more normalized immune function.

Cancer cells are known to have anywhere from ten to seventy times more insulin receptors than normal cells and depend upon anaerobic metabolism of sugar for fuel.  Intermittent fasting starves cancer cells and leaves them vulnerable to free radical damage and ultimate destruction (7, 8).


Sources For This Article Include:

1. Faris MA, Kacimi S, Al-Kurd RA, Fararjeh MA, Bustanji YK, Mohammad MK, Salem ML. Intermittent fasting during Ramadan attenuates proinflammatory cytokines and immune cells in healthy subjects. Nutr Res. 2012 Dec;32(12):947-55. PMID: 23244540
2. Vasconcelos AR, Yshii LM, Viel TA, Buck HS, Mattson MP, Scavone C, Kawamoto EM. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. J Neuroinflammation. 2014 May 6;11:85. PMID: 24886300
3. Aksungar FB, Topkaya AE, Akyildiz M. Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. Ann Nutr Metab. 2007;51(1):88-95. PMID: 17374948
4. Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio,Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda. Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice. Food and Nutrition Sciences2011, 2, 287-293 Published Online June 2011 Copyright © 2011 SciRes. Link Here
5. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010 Aug;6(6):702-10. PMID: 20534972
6. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. 2007 Jul;86(1):7-13. PMID: 17616757
7. Buschemeyer WC 3rd, Klink JC, Mavropoulos JC, Poulton SH, Demark-Wahnefried W, Hursting SD, Cohen P, Hwang D, Johnson TL, Freedland SJ. Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. 2010 Jul 1;70(10):1037-43. PMID: 20166128
8. Rogozina OP, Nkhata KJ, Nagle EJ, Grande JP, Cleary MP. The protective effect of intermittent calorie restriction on mammary tumorigenesis is not compromised by consumption of a high fat diet during refeeding. Breast Cancer Res Treat. 2013 Apr;138(2):395-406. PMID: 23446811

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15 Responses to Intermittent Fasting Boosts Your Immune System

  1. L.R. December 5, 2014 at 11:04 pm #

    Great information! Thanks for sharing this.

  2. Dr. Russell Brokstein November 25, 2016 at 4:01 pm #

    We use intermittent fasting and nutritional cleansing to benefit patients overall health

    • Dr. Jockers November 27, 2016 at 8:01 pm #

      Yes, awesome strategies that get results!!!

  3. Mark Sauer May 12, 2017 at 8:34 pm #

    I eat from noon to 6pm only. I start with apples, bananas, and blueberries. Is it bad to break my daily fast with that much fruit? I feel really good!

    • Dr. Jockers May 13, 2017 at 9:46 am #

      Hey Mark! That is a lot of fruit. I would maybe only recommend a small handful of berries or half a granny smith apple along with some healthy fats. Breaking your fast with that much fruit is probably causing a pretty strong blood sugar spike.

  4. Kelli June 15, 2017 at 11:45 am #

    Hi! is there a set food list you to use for the intermittent fasting? I am currently doing the 16:8 daily and Love it! but not sure if I am supposed just eat 2 meals with no snacking or if you can meals and snacks throughout the 8 hours as long as you are sticking to your calories and hight fat/mod protein and low carb. Can you have bananas? Thank you!

  5. Pat concienne August 19, 2017 at 4:56 am #

    I am doing chemotherapy for breast cancer when should I fast b4 treatment right after or does it matter? How long should I fast?

  6. Diane November 26, 2017 at 10:54 am #

    Hi there, just wondering how I would do intermitten fasting being a Type 1 Diabetic? Thank you.

    • Dr. Jockers November 27, 2017 at 7:50 am #

      Hey Diane, you would simply fast like anyone else and adjust your insulin dosing as necessary. As you normally would, keep an eye on your blood sugar and adjust accordingly!

  7. Jennifer Boyd January 5, 2018 at 11:33 pm #

    Yes where did You go to medical school?

  8. Raina January 19, 2018 at 9:20 am #

    Hi there , even though I haven’t been diagnosed yet I believe I have the onset of Rhematoid Arthritis. I have a positive Rhematoid Factor and joint pain in many of my joints. No obvious inflammation yet but will go to the doctor again soon to run some more tests. I know that if I do get diagnosed with RA that the medication is quite serious stuff. So meanwhile in your opinion, would fasting and following a certain diet be beneficial. If so how would I have to fast? Thank you

    • Dr. Jockers January 22, 2018 at 3:13 pm #

      Hey Raina, there are many approaches you could take. Some people do really well will strict water fasting so if you decide that that is for you, then that could be really helpful. For people dealing with issues rooted in chronic inflammation and autoimmunity, Starting with a water or bone broth fast of 3-5 days, followed by a week of liquid nutrition in the form of smoothies (high-fat, low-carb), and following that with some variation of ketogenic diet. If you would like to work with someone to help you put together a plan like this, then I highly recommend you send an email to to get started, as well as with any questions you may have!

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