Fructose Consumption & Modern Disease

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Fructose Consumption and Modern Disease:

The consumption of fructose has increased considerably over the last 50 years.  During this same period the obesity rate has more than doubled from 15% in 1970 to over 39% in 2018 (1).  Although there are many lifestyle factors to consider with this increase, the increased fructose consumption must be considered.

Fructose is a monosaccharide that is naturally produced in fruits, honey and some vegetables like corn.  Historically, humans did not consume excessive amounts of these foods but instead ate them occasionally.  Today, man has found different ways to manufacture and utilize fructose.

Uric Acid, Uric Acid: A Key Player in Cardio, Brain, and Metabolic Diseases

Government Subsidies: 

The government began to subsidize farmers to produce food products such as corn and soy.  Due to sugar tariffs and these governmental subsidies there was great incentive to make sugar alternatives out of corn (2).  High fructose corn syrup (HFCS) burst onto the commercial scene in the late 1950’s and began to grow in the 1970’s.

Food processing companies love HFCS because of its extremely low cost and its liquid nature (3).  The fact that it comes as a liquid makes it easy to utilize in soft drinks and other recipes.  Regular HFCS is 55% fructose and 45% glucose which has a similar sweetness as table sugar.  Other forms such as HFCS -90 are significantly sweeter than sugar.

HFCS is the preferred sweetener found in soft drinks, juices, teas, breakfast cereals, baked goods, condiments and other processed foods.  Other major sources of fructose include processed fruit juices and agave nectar.  Agave nectar is roughly 80% fructose and although it is considered low glycemic it is extremely dangerous due to the fructose content (4).


Fructose Metabolism and Triglycerides:  

Fructose metabolism leads directly to triglyceride formation.  Elevated triglycerides leads to weight gain, obesity, type II diabetes & heart disease (5).  In 2009, Georgia State University researchers found that the elevated triglycerides formed through fructose metabolism cause insulin resistance in the brain (6).  This leads to decreased learning and memory and accelerated brain tissue degeneration.

Fructose consumption stimulates the body’s hormonal system much differently than glucose and other forms of sugar.  Fructose turns off the natural appetite-control system by forming sugar molecules without stimulating insulin.  Typically, as insulin rises in the body it suppresses the hormone ghrelin (which initiates hunger) and stimulates leptin (which signals satiety).

Fructose disrupts this natural hormone messaging.  The result is that the individual eats more food and produces more triglycerides which damage cells and leads to insulin resistance (7).


Fructose Creates Uric Acid Toxicity

Fructose is primarily metabolized by the liver and creates stress on the liver detoxification system.  Some researchers compare fructose metabolism to ethanol alcohol metabolism due to the toxic effects they have on the liver (8).  One of the major toxic byproducts is uric acid.

When cells become damaged and are replaced their DNA/RNA degrade into purine molecules which are then metabolized into uric acid.  High consumption causes cells to burn up their energy stores and go into a state of shock that leads to massive cellular death (9).  This cellular die-off leads to excessive increases in uric acid.


Excessive Uric Acid Production:

Uric acid is an inflammatory factor that increases free radical stress throughout the body.  It depletes nitric oxide levels which leads to chronic tension and contraction in the arterial smooth muscle cells.  This process leads to arteriosclerosis and elevated blood pressure.

These sort of changes do not occur with normal starch or glucose consumption.  The average individual consumes over 40 grams daily with less than 13 grams coming from natural sources such as fruit and raw honey (10).  Many health experts believe that fructose is highly dangerous when consumed in excess of 25 grams per day (11).

uric acid

Lowering Fructose and Uric Acid

One of the best ways to lower fructose and uric acid levels is by following a diet high in protein and healthy saturated and omega 3 fatty acids and plant polyphenols.  You want to reduce sugar and starch intake and include colorful fruit and veggies and a healthy serving of protein and fats in each meal.

If you want to learn how to follow a diet that stabilizes your blood sugar, reduce inflammation and improves your brain and body, check out my advanced nutrition and recipe book the Keto Metabolic Breakthrough.

flatbread, Keto Flatbread

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Slider Buns, Gluten Free Slider Buns

Sources for This Article Include:

1. CDC: Health, United States, 2018 Link Here
2. The Foundation for Teaching Economics 2006. Link Here
3. Global Development and Environment Institute Tufts University: Sweetening the Pot Implicit Subsidies to Corn Sweeteners and the U.S. Obesity Epidemic Link Here
4. Huffington Post: This Sweetener Is Far Worse Than High Fructose Corn Syrup Link Here
5. Feinman RD, Fine EJ. Fructose in perspective. Nutr Metab (Lond). 2013 Jul 1;10(1):45 PMID: 23815799
6. Ross AP, Bartness TJ, Mielke JG, Parent MB. A High Fructose Diet Impairs Spatial Memory in Male Rats. Neurobiology of learning and memory. 2009;92(3):410-416.
7. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr. 2002 Nov;76(5):911-22. PMID: 12399260
8. Lustig RH._Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc. 2010 Sep;110(9):1307-21. PMID: 20800122
9. com: High_Fructose Corn Syrup & Gout Link Here
10. Vos MB, Kimmons JE, Gillespie C, Welsh J, Blanck HM. Dietary Fructose_Consumption Among US Children and Adults: The Third National Health and Nutrition Examination Survey. The Medscape Journal of Medicine. 2008;10(7):160.
11. Huffington Post: If You Want to Age Gracefully, Don’t Eat This Link Here

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

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Dr. Jockers

Dr David Jockers is passionate about seeing people reach their health potential in mind, body and spirit. He is the host of the popular “Dr Jockers Functional Nutrition” podcast and the author of the best-selling books, “The Keto Metabolic Breakthrough” and “The Fasting Transformation.”


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  1. I appreciate your health education. I have tried to get HFC out of my diet. Now I have to help my grandson!

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