Episode #430: The Most Important Strategies to Heal Brain Inflammation with Dr. Austin Perlmutter

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In This Episode:

In this episode, I interview NY Times Best Selling author and researcher, Dr. Austin Perlmutter, and we discuss the most important strategies to heal brain inflammation.

Unlocking Optimal Brain Health: Understanding Neuroinflammation and Gut Health

In today’s health landscape, one topic gaining significant traction is neuroinflammation and its profound impact on brain function.

Dr. Austin Perlmutter’s enlightening discussion on the Dr. Jockers Functional Nutrition Podcast underscores the importance of comprehending neuroinflammation for overall mental and physical well-being. This blog post delves into the intricacies of neuroinflammation, its manifestations, and the crucial link between gut health and brain function.

Dr. Austin Perlmutter is the bestselling author of the book Brain Wash.

Decoding Neuroinflammation

Neuroinflammation, an inflammatory response within the brain or spinal cord, is traditionally associated with severe conditions like infections or autoimmune diseases. However, recent findings suggest its involvement in common cognitive and mood disorders.

Symptoms vary from brain fog to severe conditions such as depression and Alzheimer’s disease, serving as crucial indicators of our immune status.

The Gut-Brain Connection: A Vital Bond

A fascinating aspect of neuroinflammation is its intricate connection to gut health. The gut-brain axis, a complex communication network, exemplifies this link. The gut microbiome, housing trillions of bacteria, directly influences brain health through various pathways. Microbes produce metabolites impacting brain structure, inflammation regulation, and neuroplasticity, profoundly shaping brain health.

Strategies for Brain Inflammation Management

Dr. Jockers and Dr. Perlmutter advocate diet and lifestyle changes to combat neuroinflammation effectively. Prioritizing diverse plant-based foods rich in fiber and polyphenols supports a healthy gut microbiome and, consequently, brain health.

Additionally, addressing lifestyle factors like sleep quality and stress management proves promising. Techniques like mindfulness meditation and nature exposure mitigate stress, a significant contributor to brain inflammation.

Harnessing Sleep for Brain Health

Quality sleep emerges as a critical player in neuroinflammation management. It activates the glymphatic system, crucial for clearing inflammatory toxins from the brain. Establishing a conducive sleep environment and adopting habits fostering good sleep hygiene is paramount for optimal brain health.

In Conclusion

The dialogue between Dr. Jockers and Dr. Perlmutter illuminates neuroinflammation’s pivotal role and the power of gut health in influencing brain well-being. By advocating for dietary and lifestyle adjustments, they equip individuals with practical strategies to safeguard brain health. Recognizing the interconnectedness of bodily systems offers hope and guidance, emphasizing that healing and optimal function are attainable goals.

  • 02:44 Diving Deep into Neuroinflammation with Dr. Austin Perlmutter
  • 13:53 The Gut-Brain Connection: Diet, Microbiome, and Health
  • 19:16 Optimizing Health with Diet: Fiber, Polyphenols, and Organic Choices
  • 27:18 Unlocking the Secrets of Sleep and Brain Health
  • 27:39 The Glymphatic System: A Pathway to Brain Detox
  • 29:20 The Critical Role of Sleep in Memory and Health
  • 29:37 Addressing Sleep Apnea: Risks and Solutions
  • 30:21 Lifestyle Tips for Better Sleep Quality
  • 36:11 Creating a Sleep Sanctuary: Environment Matters
  • 43:36 Stress and Its Impact on Brain Health
  • 49:49 Final Thoughts on Brain Health and Well-being

“Inflammation tells your brain to withdraw from other people, to experience low mood, potentially even to be more aggressive towards other people.”   

-Dr. Austin Perlmutter

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Dr. Jockers

Dr David Jockers is passionate about seeing people reach their health potential in mind, body and spirit. He is the host of the popular “Dr Jockers Functional Nutrition” podcast and the author of the best-selling books, “The Keto Metabolic Breakthrough” and “The Fasting Transformation.”






  1. Hello
    My 32 year old son sustained severe traumatic brain injury in MVA in 2015.
    Was not expected to live – but God!
    He has come a long way still a long way to go. Spasticity, short memory, gut health (extreme weight loss) has developed Hidradenitus suppuritiva 4 years ago so on a very limited diet (no sugar/yeast/egg white/gluten/dairy/nightshades) can you help?

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