Multiple Sclerosis: Causes, Symptoms & Natural Support Strategies
Multiple sclerosis (MS) is a chronic inflammatory disease in which the myelin sheath on the nerve endings gets inflamed and damaged. This leads to scarring of the neurological tissue in the brain and spinal cord. While the medical model has very little support, many individuals have found ways to beat multiple sclerosis with natural lifestyle strategies. In this article, you will discover natural support strategies to improve your inflammatory response.
MS is a condition in which the body’s own immune system attacks the fatty myelin sheaths that insulate nerve tissue. This results in scar tissue plaques that disrupt neurological signals throughout the body. MS actually means multiple scars/plaques/lesions. One of the major areas that is affected is the white matter of the brain and spinal cord which is mostly myelin (1).
Multiple Sclerosis Pathogenesis:
Multiple sclerosis affects approximately 400,000 people in the United States alone, and 2.5 million worldwide, most of them being young adults. It expresses itself in four clinical forms: relapsing remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and progressive relapsing MD (PRMS).
Approximately 87% of patients present with RRMS, characterized by acute attacks (relapses) followed by partial or full recovery (remission). Patients can manifest with a heterogeneous group of symptoms including changes in vision (unilateral visual loss, diplopia), weakness, dyscoordination, sensory loss or distortions, or changes in bowel and bladder function (1, 2).
Less diagnostic but also disabling symptoms include cognitive change, fatigue and mood disturbance. Progression of disease may eventually lead to severe disability. Life expectancy is 5 – 10 years less than the normal population.
Chronic Neurological Inflammation:
The MS disease is characterized by chronic inflammation within the nervous system. It is believed to be an auto-immune disease where the T lymphocytes attack the protective sheath (the myelin sheath) around the white areas of the brain including the brain stem, optic nerve, basal ganglia and spinal cord (3, 4).
The white matter functions to carry signals between the gray matter regions, where the major processing is done and the rest of the body. When the myelin is lost the neuron can no longer effectively conduct electrical signals. The major cells that form the myelin are called oligodendrocytes (OD).
Remyelination and Glial Activation:
The body tries to remyelinate in the early phases of the disease but is unable to because the OD cells are under constant immune attack. As the OG cell numbers go up, the immune system in the brain which is controlled by the microglia cells becomes more active and this results in an aggravation of the MS process. This is called glial activation and upon repeated destruction of the OG cells and myelin sheath this process leads to scar-like plaques that developed around the damaged neurons (5).
Additionally, MS is characterized by a breakdown in the blood brain barrier (which protects the brain from toxins, infectious microorganisms and our own immune system) and T lymphcytes which are normally unable to cross the blood brain barrier are able to enter into the neurological tissue. These T lymphocytes agitate more inflammatory mechanisms and promote swelling and further tissue destruction.
Chronic inflammatory disorders are characterized by a hyper responsive immune system. There are several key factors that must be addressed to regulate and better coordinate the immune system.
1. Poor Blood Sugar Stability: Blood sugar imbalances cause immune dysfunction and malcoordination. Stable blood sugar is critical for a healthy immune response.
3. Gut Dysbiosis: Poor microbial balance in the gut microbiome leads to leaky gut syndrome and chronic inflammation (7). The gut must be addressed in order to get well.
4. Mitochondrial Dysfunction: The mitochondria are the energy producing organelles in each cell of the body. They are extremely key in the bodies ability to handle oxidative stress. Dysfunction in the mitochondria leads to increased free radical and oxidative stress which creates immune alterations. Many researchers believe that multiple sclerosis is primarily a mitochondrial disease (8).
5. Low Glutathione Levels: Glutathione is the major anti-oxidant within every cell of the body. It is critical for white blood cell (WBC) function as the WBC’s encounter tremendous amounts of free radical and oxidative stress every second of the day. Low glutathione leads to chronic inflammation and often to auto-immunity (9).
6. Poor Omega 6:3 ratio: The average person has significantly more omega 6 fats than omega 3 fats. The increased omega 6 stimulate the release of pro-inflammatory mediating prostaglandin molecules. This is a key factor in the development of chronic inflammation and auto-immunity (10).
7. Upper Cervical Subluxation: The bottom of the skull (occiput) and the first bone (atlas) play a significant role in the coordination patterns of the brain and immune system. Dysfunction at this joint torques and compresses the top of the spinal cord and increases inflammatory activity in the body (11).
8. Environmental Toxins: Exposure to high levels of infectious microbes, environmental chemicals such as plasticizers, pesticides, herbicides, personal care products, heavy metals and biotoxins such as mold wear down the bodies glutathione levels, alter the gut microflora and increase inflammatory activity in the body (12, 13, 14).
9. High Stress and Poor Breathing Habits: High mental and emotional stress increases stress hormone production which induces inflammatory activity within the body. Short and shallow breathing habits can simulate chronic mental and emotional stressors on the physiological level (15).
10. Lack of Sleep: Poor sleep promotes immune dysfunction and increased inflammation. Good sleeping habits and optimal melatonin secretion reduce inflammation and promote improved tissue healing (16).
11. Methylation: Methylation is a key process that protects DNA, turns on and off genetic traits and helps to detoxify environmental chemicals. Many individuals have certain genetic polymorphisms that limit their ability to appropriately methylate. Methylation plays a very important role in T cell function and poor methylation status is associated with the development of auto-immunity (17).
12. EMF Exposure: Electromagnetic frequency exposure has been shown to alter the function of the immune system and increase one’s susceptability to developing an auto-immune condition (18) I will touch on a few of these key areas and how they relate to MS in this article.
Blood Sugar and Multiple Sclerosis:
Blood sugar balance is critical for sustained energy production and immune control throughout the body. When our blood sugar gets too high (hyperglycemia) the sugar molecules bind to proteins in the body and create Advanced Glycolytic Enzymes (AGEs).
The AGEs destroy cell membrane function and damage insulin receptor activity creating a vicious cycle of elevated blood sugar and inflammatory stress. AGEs cause massive destruction throughout the body and have an affinity for neurological tissue.
When the blood sugar drops too low (hypoglycemia), it causes the blood brain barrier to become more permeable in order to get more sugar into the neurological tissue. Part of this characterization is a reduction in Interleukin-25 (19). This permeability opens the door for toxic debris and inflammatory molecules (such as TNF-alpha) to get into the brain tissue and cause major problems. This is a serious problem in the pathogenesis of multiple sclerosis (20)
Vitamin D and Multiple Sclerosis:
One of the major epidemiological factors associated with MS is its striking difference in number of cases based on geography and climate (21). Those living close to the equator have significantly lower risk of MS. This is due to the beneficial effects of regular sun exposure and vitamin D intake in modulating healthy immune responses.
In the Northern hemisphere, most people have increased vitamin D3 levels in the fall after a full summer of increased UV light exposure. January –April are usually when the lowest levels are reached.
Multiple studies have shown that more individuals who develop MS and other auto-immune related conditions are born in May/June than in October/November (22, 23). This would indicate that low motherly D3 levels lead to developmental and maladaptive immunological responses in the child. D3 levels should be between 60-100 ng/ml for optimal immunological expression.
The Microbiome and Multiple Sclerosis:
There has been a tremendous amount of research linking the gut microbiome and neurological health. Research has indicated that low levels of healthy lactobacillus and bifidobacterium are linked with increased brain and nervous system excitability and neurological inflammation (24, 25).
Studies are revealing how diverse forms of neuro-immune and neuro-psychiatric disorders are correlated with or modulated by variations of microbiome, microbiota-derived products and exogenous antibiotics and probiotics. The microbiome helps to prime and balance the immune system and unfavorable alterations increase the susceptibility for autoimmune diseases such as multiple sclerosis (26, 27).
Leaky Gut Syndrome and Auto-Immunity:
When the microbiome is dysregulated it often leads to a damaged gut lining and intestinal permeability. This is found in the pathogenesis of mutiple sclerosis and other auto-immune diseases (28, 29). This “leaky gut” causes undigested food particles to pass into the bloodstream where they are tagged by the immune system and attacked with massive inflammatory processes that have the ability to affect nearly every system in the body.
This creates a food allergy or sensitivity that the body reacts to whenever it is exposed. The most common food based culprits include all processed foods, artificial sweeteners/preservatives and gluten containing products. Soy, peanuts, pasteurized dairy, corn and eggs are often not tolerated well. The nightshade family of eggplant, potatoes and tomatoes are often challenging on the system as well.
Every cell of the body has mitochondria within it that produce energy for the cell. The mitochondria are the battery packs of the cell and they are extremely important. High levels of oxidative stress wear down the mitochondria and cause a dysfunctional state.
Mitochondria are one of the main cellular sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and play a pivotal role in many neuro-pathological conditions. Mitochondrial dysfunction leading to excessive production of ROS and RNS plays a significant role in the pathogenesis of MS, particularly in loss of myelin/oligodendrocyte complex (30, 31).
Supporting the mitochondria with clinically effective doses of mitochondrial nutrients such as CoQ10, L-carnitine, N-acetyl cysteine and lipoic acid has been shown to be extremely effective for improving mitochondrial health and MS (32, 33, 34).
Glutathione Depletion and Nrf2:
In multiple sclerosis, the cells are under so much stress that there main protective shield, glutathione (GSH) gets worn down and oxidative stress damages the mitochondria and the DNA leading to cell death. Poor blood sugar control and high environmental toxin exposure are known to deplete glutathione levels and impair mitochondrial function (35, 36).
A key pathway that maintains cellular glutathione levels and the ability of the cell to adapt to stress is called Keap1-Nrf2. When this pathway breaks down it causes increased levels of oxidative stress within the cell that leads to the glutathione depletion and mitochondrial dysfunction (37).
Anti-Inflammatory Diet & Lifestyle
Anti-inflammatory foods help to modulate the immune system and reduce inflammatory activity in the body. Great anti-inflammatory foods include coconut products, avocados, olive oil, berries & phytonutrient rich vegetables. Healthy meat sources such as grass-fed beef, wild game, wild salmon, organic poultry and organic eggs are great if the gut can tolerate them.
It is advisable for anyone with chronic inflammation to include organic vegetable juices, fermented foods and herbal teas in their diet. Homemade sauerkraut, apple cider vinegar, coconut water kefir, and kimchi are great. Begin with small doses of all of these and add more if you tolerate them well.
Organ meats such as grass-fed liver, heart, etc. are rich in mitochondrial support nutrients. Powerful herbs such as turmeric, ginger, garlic, onion, rosemary, thyme, cinnamon, & oregano among others should be used as much as possible to improve immune coordination.
Consuming lots of sulfur based onions, garlic, cruciferous veggies on a daily basis and getting high quality seaweed in the form of kelp can be extremely helpful. Using purified fish oils to boost up omega 3 levels is also very important.
Upper Cervical Subluxation and Multiple Sclerosis:
People with MS are highly likely to have neurological dysfunction in their upper neck. Subluxation, or neurological interference, at the bottom of the skull, C1 & C2 alters blood supply, stress hormone release and immune modulation throughout the body. Research has found this problem to be very common in MS patients (38)
Upper cervical subluxation leads to increased states of pain, fatigue, anxiety and accelerated stress as well as mal-coordinated immunity (39). Well trained chiropractors can analyze these regions of the spine and give specific corrective adjustments to restore balance and optimal neurological expression in these regions. This reduces the stress response and improves endorphin release. This improves the individual’s pain levels, stress tolerance, immune function and overall well-being (40).
21 Immune Support Strategies
Here are the best action steps to get started with on your journey to improve your immune system. These strategies are not FDA approved at this time to prevent, mitigate, treat or cure multiple sclerosis and should not be confused as such. You should always consult with your physician before stopping or changing medications or taking on new health strategies.
Additionally, you should be working with a functional health practitioner to help guide you through these strategies. This is not an exhaustive list and there are other natural therapeutic strategies that I and functional health practitioners will utilize to help individuals with Multiple Sclerosis.
2) Test For Food Sensitivities: You can do a biofeedback test to determine what foods are causing stress in your system and an elimination diet to test how you are responding to eliminating certain foods for periods of time.
3) Reduce Stress: Find ways to reduce stressful activities and enjoy more peace and calm. Learn to thrive under stress by reading this article here
4) Improve Your Sleep: Sleeping a high quality 8-9 hours each night is key to healing and improving brain function. Follow the steps in this article to improve your sleep.
5) Power Up Your Nrf2 Pathway: This is the key genetic anti-oxidant pathway. Adding in clinical dosages of resveratrol, curcumin, sulfuraphane and Green tea (ECGC) can be extraordinarily beneficial. I use Nrf2 Power here to improve this pathway. I always get my chronic hypertensive patients on Nrf2 Power.
6) Include Magnesium & B Vitamin Rich Foods: Magnesium helps to improve blood sugar signaling patterns and protects the blood-brain barrier. The best magnesium and B vitamin rich foods include dark green leafy veggies, grass-fed dairy, raw cacao and pumpkin seeds. Consume these as tolerated. You can also do Epsom salt baths to boost your magnesium levels.
7) Focus on Deep Breathing: Improving your posture, seeing a high quality chiropractor and optimizing your breathing patterns is highly recommended. Follow these tips here to improve your breathing patterns.
8) Use Anti-Oxidant Rich Herbs: Add turmeric, ginger, oregano, garlic, basil, thyme and rosemary to as many dishes as possible and drink organic herbal teas on a regular basis.
9) Ground Your Body: In our society we are surrounded by toxic electromagnetic frequency’s (EMF’s). These EMF’s increase stress within our body and alter neurotransmitter function. By going outside daily and walking barefoot on grass, dirt or sand you absorb natural EMF’s from the ground that balance your electrical rhythms. Follow the steps in this article here.
10) Supplement With Omega 3’s: Omega 3 fatty acids and in particular the long chain variety EPA and DHA are critical for stabilizing blood sugar, reducing inflammation and pain. Consume grass-fed meat, grass-fed butter, wild-caught fish and spirulina to get it in your diet. It is also advisable to supplement with 2-5 grams daily of EPA/DHA along with other anti-oxidants like curcumin and glutathione. Clinically, I use Pro Omega CRP to boost up omega 3’s.
11) Improve Your Mitochondria: The mitochondria are the energy powerhouses of every cell. When someone has MS it is a clinical sign that they have dysfunctional activity going on in the mitochondria. Support your mitochondria with clinical doses of CoQ10, L-carnitine, N-acetyl cysteine and Lipoic acid.
A great supplement I use to improve mitochondria and neurological health is Brain Supercharge which has the clinically effective dosages of each of these key nutrients and more. It is important to remember that this is not FDA approved to prevent, mitigate, treat or cure multiple sclerosis and should not be confused as such.
12) See a Chiropractor: Have a full neurological exam and see a high quality chiropractor to help reduce stress on the nervous system and enhance overall well-being.
13) Juice Your Veggies: Juicing is one of the best ways to get high quality anti-oxidants and powerful phytonutrients into your system. Here is my article on Best Juicing strategies.
14) Intermittent Fasting: Going 16 hours between dinner and breakfast is one of the best ways to improve mitochondrial production. Your body improves energy efficiency by increasing and strengthening the mitochondria during periods of fasting. This is also one of the best ways to reduce oxidative stress and inflammation. Consume your meals in an 8 hour window such as 11am – 7pm. Read this article for more info on fasting.
15) Optimize Your Vitamin D: Low vitamin D3 is associated with neurological inflammation and neurodegenerative conditions (37). Be sure to increase your vitamin D through good amounts of regular sun exposure and/or taking a high quality vitamin D3/K2 supplement.
16) Practice Oil Pulling: Oil pulling helps to reduce the microbial load in your mouth. This takes stress off of the immune system and reduces inflammation levels throughout the body. Read more about oil pulling here and practice this 2x daily.
17) Get a Home Water Filtration System: Very important to avoid the chloride, fluoride, pesticides, heavy metals, etc. that are found in tap water. Use a good whole home water filtration system as discussed in this article here
18) Use Essential Oils: The anti-oxidant content and aromatherapy benefits of essential oils help to improve oxygenation and reduce the harmful effects of oxidative stress throughout the body. Some of my favorites include lavendar, peppermint, chamomile and sweet orange among others. Put a drop on your hands and mix together and then cover your nose and inhale the healing vapors. This will stimulate your brain and increase blood flow to your cranium.
19) Low Intensity Movement: A sedentary lifestyle reduces cerebrospinal fluid flow and can lead to increased oxidative stress in the brain. Throughout the day, get a lot of low-intensity movement such as walking, light cycling, playing, etc. Regular movement will help reduce inflammation and boost the development of new neurons in the brain.
20) Improve Your Gut Motility: Improving bowel movement frequency and consistency is a key detoxification concept. Consuming an anti-inflammatory diet with good fiber sources such as chia seed and flax seed, using bone broths, fermented foods and probiotics will improve bowel motility.
21) Use an Advanced Brain and Nervous System Nutrient Support Pack: This is designed to get you the key nutrients that are we have already discussed that are necessary for optimal function while improving the inflammatory process and neurological expression. It is important to remember that this is not FDA approved to prevent, mitigate, treat or cure multiple sclerosis and should not be confused as such.
My good friend Jonathon Otto has interviewed some of the top experts on autoimmune disease and inflammation and found some of the top strategies for reducing pain and improving brain health. Here are just a few things you’ll discover:
- The special oil has shown to inhibit inflammation-causing chemicals involved in autoimmune disease…
- The soil-derived natural compound that helps protect your brain from dementia and Alzheimer’s, according to a 2011 study published in the Journal Of Alzheimer’s Disease…
- The “golden” spice that demonstrates an anti-inflammatory effect equivalent to that of several popular NSAID drugs, such as ibuprofen and naproxen (plus, it also helps depression)…
- This freshwater “superfood” not only fights inflammation, but may also help prevent dementia and Alzheimer’s…
- And much more…
Unfortunately, you won’t find out about these remedies from your doctor any time soon.
But you can download them here. We have 2 free reports to take advantage of, simply click the links and put in your email. You will also be reserving your spot for the Natural Medicine Secrets docu-series which begins on June 29th.
Take advantage of these 2 E-guides which will give you a great insight into what you can do today to reduce inflammation and pain and improve your brain health!