3 Heart Healthy Benefits of Using Natto

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3 Heart Healthy Benefits of Using Natto

Natto is a fermented cheese-like food that has been used in Asia for over 1000 years. These native cultures used this dish as breakfast food and it was known as a remedy for heart and vascular diseases.  In this article, you will discover 3 heart healthy benefits of using natto.

Research has found both vitamin K2 and a powerful enzyme nattokinase within this food.  Nattokinase and vitamin K2 have extraordinary cardiovascular protective qualities that are not well understood by most clinicians and the mainstream public.

The unfermented soybean is a very challenging food to digest properly due to the high amount of phytic acids (1, 2). These phytates bind to major minerals such as zinc, calcium, & magnesium and pull them out of our body.  Unfermented soy also has enzyme inhibitors and goitrogens that challenge the bodies enzymatic and thyroid hormone systems.


Fermented Soy Removes Anti-Nutrients:

Soy can be deeply fermented with various microorganisms to remove the phytates, enzyme inhibitors and goitrogens. This fermentation process makes it more bioavailable and loaded with live enzymes and healthy microorganisms.  Tempeh, miso, & natto are prime examples of fermented soy.

Natto is made from small soybeans as this speeds up the fermentation process.  The beans are soaked in water for 12-20 hours to remove phytic acids.  The beans are steamed or pressure cooked.  The beans are then mixed with the Bacillus natto (natto-kin in Japanese) bacterium (3).

The mixture is fermented at 40 degrees for up to 24 hours.  Natto is then cooled and aged in the refrigerator for up to a week to allow optimal development.  The aging period allows the bacilli to develop spores and the nattokinase enzyme to break down the protein into a more bioavailable form.


Natto is Anti-Inflammatory:

Natto is the only form of fermented soy that utilizes the bacillus natto species. The byproduct of this fermentation is the powerful proteolytic enzyme, nattokinase.  This enzyme is known to be a very strong fibrinolytic (anti-clotting), anti-inflammatory and blood thinner (4, 5).

It is comparative to aspirin without the dangerous side effects.  Additionally, nattokinase has been shown effective in destroying the toxic amyloid fibrils associated with Alzheimer’s disease (6, 7).

Japanese researcher Dr. Hiroyuki Sumi tested many traditional Japanese foods looking for a natural thrombolytic agent that could break down blood clots and arterial plaque. After testing more than 173 natural foods, Sumi found what he was looking for in 1980 with nattokinase (8).

He dropped natto into an artificial thrombus in a petri dish and allowed it to sit at body temperature.  Over the next 18 hours, the plaque completely dissolved.  Dr. Sumi isolated the active enzyme and named it nattokinase.  Researchers have acknowledged that nattokinase has a potency matched by no other enzyme.

More Potent than Any Medication:

Nattokinase works so effectively because it dissolves existing blood clots & fibrinwhile enhancing the bodies production of plasmin and other fibrolytic agents like urokinase.  Researchers agree that nattokinase is 4 times as potent as plasmin and is significantly better than any prescription medication (9, 10).

It works for longer periods of time without any of the dangerous side effects associated with warfarin (Coumadin).  Many individuals use this instead of Coumadin but it always advised to discuss the pros and cons of this with your physician.

Natto is Rich in Vitamin K2:

Natto is also one of the best forms of vitamin K2 which is very important for binding calcium in proteins.  K2 is especially important for both bone and cardiovascular health.  Vitamin K1 is easier to come by as it can be found in seaweed & dark green leafy veggies.  Vitamin K2 is found in fermented foods such as raw cheese, miso, & Natto.

Vitamin K2 activates a key hormone called osteocalcin that is produced by osteoblasts. This hormone is needed to bind calcium into the bone matrix.  Osteocalcin also prevents calcium from being deposited into the arteries (11, 12).

Without adequate vitamin K2 an individual cannot effectively get calcium into the bone matrix and will instead deposit it into arterial endothelium creating plaque deposits.

NattoKinase and Serratiopeptidase:

Serratiopeptidase is an enzyme isolated from a non-pathogenic bacteria called enterobacteria Serratia E15. This enzyme makes its inhabitants in the intestine of the silkworm. Silkworms go through a transformational process within a cocoon that turns them into moths. It is this specific enzyme that is used by the silkworm to dissolve the cocoon and reemerge as a moth.

Serratiopeptidase has powerful anti-inflammatory properties and is particularly useful for post-traumatic swelling, fibrocystic breast disease and bronchitis. It is able to digest dead tissue, blood clots, cysts, and arterial plaques. Clinical studies have shown it to be effective at reducing swelling and edema and metabolizing scar tissue in the body (13, 14).

I have found a combination of nattokinase and serratiopeptidase is excellent for reducing inflammation and scar tissue associated with blood clots and neurofibrial tangles in Alzheimer’s (15).  Rat studies have shown very promising effects of using these two together with their clinical doses of nattokinase (150mg) and serratiopeptidase (30mg).  Here is the product I recommend to my clients.


Sources For This Article Include:

1. Hurrell RF, Juillerat MA, Reddy MB, Lynch SR, Dassenko SA, Cook JD. Soy protein, phytate, and iron absorption in humans. Am J Clin Nutr. 1992 Sep;56(3):573-8. PMID: 1503071
2. Reduction of Phytic Acid in Soybean Products Improves Zinc Bioavailability in Rats. Link Here
3. Kubo Y, Rooney AP, Tsukakoshi Y, Nakagawa R, Hasegawa H, Kimura K. Phylogenetic Analysis of Bacillus subtilis Strains Applicable to Natto (Fermented Soybean) Production . Applied and Environmental Microbiology. 2011;77(18):6463-6469.
4. Hsia CH, Shen MC, Lin JS, Wen YK, Hwang KL, Cham TM, Yang NC. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009 Mar;29(3):190-6. PMID: 19358933
5. Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Park SK, Lee SP, Choi EK, Rhee MH, Kim YB. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013 Dec;29(4):221-5. PMID: 24396387
6. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. J Agric Food Chem. 2009 Jan 28;57(2):503-8. PMID: 19117402
7. Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7):721-35. PMID: 23821590
8. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987 Oct 15;43(10):1110-1. PMID: 3478223
9. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995 Oct;18(10):1387-91. PMID: 8593442
10. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K.Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. PMID: 12620531
11. Seyama Y, Wachi H. Atherosclerosis and matrix dystrophy. J Atheroscler Thromb. 2004;11(5):236-45. PMID: 15557705
12. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-5. PMID: 15514282
13. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88. PMID: 2257960
14. Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7):721-35. PMID: 23821590
15. Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7):721-35. PMID: 23821590

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Dr David Jockers is passionate about seeing people reach their health potential in mind, body and spirit. He is the host of the popular “Dr Jockers Functional Nutrition” podcast and the author of the best-selling books, “The Keto Metabolic Breakthrough” and “The Fasting Transformation.”


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  1. I have eaten Natto daily for past 18 month to help with my Aortic Stenosis (AS).I recently had an Echocardiogram which shows my AS improving over past year.

  2. diclofenac 1% on the knee quickly precipitated blood clot in already thrombosed peritoneal vein. Tbsp miso daily immediately reversed this pathology, with calf exercises. Still improving, swelling gone. DF

  3. Is it ok to take serrapeptase daily as a preventative or should it only be taken if you are aware of a medical issue? If so, what dosage is recommended? Thank you.

  4. I ‘ve just approached to Nattokinase recently in order to look for a suitable way for my kid’s digestion. Does Nattokinase work for digestion improvement such as increasing food absorb ability?

  5. I have been eating 1 packet of Natto every 2nd day for almost 3 years.
    It is the frozen product from Japan and comes in 45mg polystyrene packets. I have recently been informed that freezing Natto kills any of its benefits, like vitamin K2, nattokinase, probiotics and all the other good stuff it contains. Is this true?

  6. For multi artery blockages of 80%.

    I was told by my friend of mine to take 1 100mcg Cap of Vit K2 mk -7 form every day.
    I got the bottle an it has warning that I should not use this if I am using other on blood thinners. I am using Diovan , hydrochlorozide and Aspirin.

    My doctor does not believe in Vitamin K2. Please advise

    1. Hello Kishore, we are unable to give medical advice on medications but we will say that vitamin K2 has very little blood thinning effect and instead works to improve calcium metabolism.

  7. Thanks Dr, do you mind briefly explaining or potentially writing an article about what evidence exists to justify which SBOs and what amounts (CFUs) may be safe for those with autoimmune issues and/or leaky gut? I’ve heard fermented foods, like Natto, and in general, should only be taken once one’s bowel movements are regular. I’ve heard and am concerned that some of these SBOs can cause serious infections.

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