3 Major Benefits of Vitamin K2

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Vitamin K2

3 Major Benefits of Vitamin K2

Vitamin K2 has been studied for the last 80+ years and known to be a critical nutrient.  Most of the research has focused on vitamin K1 and its effects associated with blood coagulation.  New studies are looking at another subtype called vitamin K2 and its effect in synergy with Vitamin D3 on various health factors.  Vitamin K2 appears to be a very important nutrient for healthy bones, joints and cardiovascular function.

Vitamin K was originally discovered in 1929 by the Danish scientist Henrik Dam.  Dam investigated the role of cholesterol as an essential nutrient by feeding chickens a cholesterol-deficient diet.

After a few weeks the animals developed bleeding disorders that could not be restored by adding purified cholesterol to their diet.  They discovered another nutrient that coupled with cholesterol in order to create the coagulation response.  The new vitamin was named K as it was discovered in Germany as Koagulations vitamin.

Three Main Forms of Vitamin K:

K1: Phylloquinone, phytonadione

K2: Menaquinone

K3: Menadione – Synthetic variant

Vitamin K has Unique Benefits:

Vitamin K1 is necessary for blood coagulation and is produced by green leafy vegetables.  The best sources include kale, spinach & collard greens.  This form of vitamin K is required for the formation of anticoagulant factors protein C & S.

Vitamin K2 is necessary to convert a critical bone-building protein called osteocalcin.  Osteocalcin is a necessary protein that helps maintain calcium homeostasis in bone tissue.  It works with osteoblast cells to build healthy bone tissue.  Inadequate K2 inhibits osteocalcin production and reduces calcium flow into bone tissue.  This leads to reduced bone mass and a weakened bone matrix (1).

D3 and K2 for Healthy Calcium Metabolism:

Vitamin D3 is another critical nutrient that plays an essential role in calcium uptake into skeletal bone tissue.  Several studies have shown a synergistic effect of vitamin K2 and D3 (2).  These studies show that this combination enhanced osteocalcin accumulation in bone cells greater than any one of these nutrients alone.  This increased osteocalcin formation significantly improved bone mineral density (3).

Vitamin K and vitamin D work to increase a substance called Matrix GLA protein (MGP).  This protein protects the blood vessels from calcification by congregating around the elastic fibers of the arterial lining and guarding against calcium crystal deposition.   Some researchers believe that MGP is the most powerful inhibitor of soft tissue calcification presently known.

Cardiovascular and Joint Health:

Vitamin K and Vitamin D also play a very important role in cardiovascular and joint health.  When soft tissues such as the arterioles are damaged due to oxidative stress the body responds with an inflammatory process.  This process results in a deposition of calcium into the damaged tissues.  This creates plaque buildup in arterioles and degenerative bone spurs in joints.

Animal studies have shown that vitamin K2 not only prevents arteriosclerosis and atherosclerosis but actually has the potential to reverse arterial calcification by activating MGP (4).  The Rotterdam study in 2004 demonstrated that people with the highest intake of vitamin K2 had a 50% lower risk of death from heart disease than people with the lowest rates of K2 (5).

Vitamin K2 and Your Gut Flora:

Vitamin K2 production within the body is dependent upon a healthy gut flora and the consumption of fermented foods.  The vast majority of our society is deficient in vitamin K2 due to lack of fermented food consumption and the epidemic of gut dysbiosis.  This is only potentiated by the overuse of anti-biotics and consumption of industrial sterilization products and processed foods.

The best sources of vitamin K2 are found in the fermented soy product natto and raw cheese from a 100% grass-fed cow or goat.  Saurkraut and kimchi can also contain vitamin K2, but typically in lower amounts around 10-15 mcg per cup.

Raw cheese has the ideal ratio of vitamin K2 and vitamin D3 along with other nutrients that make it the perfect food for healthy bones, joints and cardiovascular function.  Raw, grass-fed cheese can be an excellent part of one’s diet as long as they do not have food sensitivities to dairy and are able to digest and absorb the nutrients.

You can find high quality grass-fed cheese through US Wellness Meats here


Best Way to Supplement Vitamin K2:

I recommend supplementing with probiotics for a healthy gut microflora that can naturally produce vitamin K2.  A healthy gut microbiome is foundational to good health and one of the first places to start with all conditions.  A healthy gut microbiome and the consumption of grass-fed dairy, fermented veggies and pasture-raised egg yolk will provide a good amount of bioavailable K2.

If you are not sun bathing on a regular basis and are in need of a vitamin D3 supplement than I recommend using vitamin K2 with D3 supplementation.  This is very important as these two work in synergy.  When they are out of balance it could lead to health problems.

I will often have my clients use a concentrated form of Vitamin K2 in combination with D3.  This combination addresses both major deficiencies and these are nutrients that are body needs each day so this is a great lifestyle based supplement.  I like to see D3 levels between 70-90 ng/ml.  I use the following formula:

To Boost D3/K2 Levels:  2,000 IU and 36-400 mcg for every 25 lbs of body weight

This typically will add 15-20 IU to your blood D3 levels each month.  If your levels are 20 – do this for 3 months to get you to 80 (be sure to test to make sure)

For D3 Maintenance:  1,000 IU and 18 mcg of K2 for every 25 lbs of body weight

We have these ratios set up in an easy to use liquid dropper here or this capsule formula here



Sources For This Article Include:

1. Koshihara Y, Hoshi K. Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. J Bone Miner Res. 1997 Mar;12(3):431-8. PMID: 9076586
2. Hosoi T; World Health Organization. [Absolute risk for fracture and WHO guideline. Pharmacological intervention to prevent osteoporotic fractures in the elderly]. Clin Calcium. 2007 Jul;17(7):1098-104. Japanese. PMID: 17607078
3. Koshihara Y, Hoshi K, Ishibashi H, Shiraki M. Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts. Calcif Tissue Int. 1996 Dec;59(6):466-73. PMID: 8939773
4. Seyama Y, Wachi H. Atherosclerosis and matrix dystrophy. J Atheroscler Thromb. 2004;11(5):236-45. PMID: 15557705
5. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-5. PMID: 15514282

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  1. Just wanted to say that your e-mail is the one I ALWAYS enjoy receiving. I am studying to be a nutrition health coach and have learned so much from your e-mails and videos. You’re making a positive impact in this world. Thanks for sharing!

  2. Thanks for the information. I’ve been reading the book, Vitamin K2 and the Calcium Paradox. The chapter I’m currently on has been talking about how both Vitamin A and D3 are needed so that Vit K2 works properly; you can’t use just one in your diet or via supplementation. What’s your opinion?

  3. Please Docter is taking k2 effect the liver because I have liver problem but since I have joint I really need to take this vitamin thanks a lot for every thing

  4. I am on eloquist for a Fib and it blocks k2 . Is there anything I can do to get in balance? I hope to get off of eloquist in a couple of months.

    Is there a natural product that would work as well?

  5. I have a spur on the base of my thumb and heel spurs both feet and I feel a little on the medial side of my elbow. Do you think K2 would help and how much? And does this effect any medications?

  6. my father is 91. He had CVD and he had multi-bypass 23 yrs ago and stent(s) yrs ago. He takes daily aspirin, statin and a few other med’s.
    His Vit D is 10 and considering D3 supplementation. Can he also take Vit k2 MK-7? what dose should he take?
    His CRP is very high at 6.9.
    Any other supplements you reco?
    Omega 3?

  7. Dr Jockers

    I have an urgent question. After reading this artical, i understand that if we want to take vitamin D3, we have to take it with vitamin K2 due to the advise that taking D3 (absorption of calcium might accumulate in the arteries hence needing K2 to transport calcium to the bones), but can i take k2 without taking D3 (only transporting calcium to the bones) assuming i am getting alot of sun where I live? I do not want to overdose on D3

    Will taking k2 alone be ineffective to what i am trying to do i.e decalcificating calcium from my arteries

  8. I have read that a combination of vitamins C and K3 is good for people who may be having a reaction to the titanium in their total knee replacement. How would you you know if this is your problem and do you know where K3 is available?

  9. Dear Sir,
    Very informative and healthy presentation. i appreciate. Please let me know the ideal combination for Bone health including Vitamin K2 and Vitamin D3 etc.

  10. Dr. Jockers.
    I am using Thornes product.
    2 drops get me 1000IU of D3 and 200mcg of K2.

    They recommend two drops 1-3 times daily. I want to know how much K2 I can take in one day before it could cause a problem.

    I would like to take the two drops at least 5-6 times per day. As soon as the liquid hits my tongue I feel as if it’s something I need. I start to feel a little better. I’m thinking it’s the D3 which is why I want to know what I can max up to on D and K2 per day.

    Thank you,

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