How to Use Systemic Enzymes For Cancer

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use systemic enzymes

How to Use Systemic Enzymes For Cancer

Enzymes are extremely vital to human well-being.  They play a critical role in digestion and nutrient assimilation, in immune response, cognitive acceleration, and cellular detoxification among other things.  Enzyme therapy has shown incredible promise in natural protocols for cancer since the early 1900s (1).  In this article, you will discover how to use systemic enzymes for cancer.

Enzymes are some of the most important structures in the body.  They are long-chain proteins that take on specific shapes and act like a key to unique locks throughout the body.  Their job is to carry out very specific functions throughout the body.  They assist the body in healing and regenerative functions as well as immune system modulation that plays a very important role in disease development.

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

What Are Enzymes?

Enzymes are biocatalysts that are used to carry out and speed up the process of chemical reactions in the body.  We have roughly 3000 unique enzymes in our bodies that are involved in over 7000 reactions.

We also consume enzymes when we eat raw, sprouted and fermented fruits and vegetables.  Supplementing with an array of plant and mammalian enzymes has been shown to have powerful health benefits in a number of different health conditions including cancer (2,3).

digestive enzymes, 10 Benefits of Digestive Enzymes

Cancer Cells and Enzymes

Cancer cells are covered in fibrin which is a thick outer coating designed to prevent the bodies immune system from identifying and destroying the cancer cell.  This fibrin defense keeps chemotherapy out of the cells unless industrial strength doses are used.  This high dose chemotherapy is also extremely toxic to the body.

Systemic enzymes have been shown to break down the outer fibrin wall of the cancer cell making it easier for chemotherapy to penetrate and destroy the cancer cells (4).  This allows lower dosages of chemotherapy to be used.  Enzyme therapy has also shown to reduce the side effects of chemotherapy and reducing the debilitating muscle wasting that chemo therapy produces (5).

Patients undergoing chemotherapy often have many side effects such as nausea, vomiting, diarrhea, pain and fatigue.   Research has shown that enzyme therapy reduces these symptoms by reducing the cytotoxic effects of chemotherapy to the rest of the body (5).

natural cancer, Top 10 Natural Cancer Treatments

Radiation, Surgery and Enzymes:

Radiation treatment damages the organs it is affecting and creates rigid scar tissue build-up throughout the organ.  This restricts the organs ability to function.  Systemic enzyme therapy prevents this scarring and breaks down existing fibrosis to enhance the organs function.

They also improve outcomes associated with surgical procedures (6).  Patients report faster recovery when using systemic enzymes before and after the surgical procedure.

Radiation, Radiation Exposure: Causes, Symptoms and Support Strategies

Enzymes and Immune System:

Enzymes have also shown to decrease inflammation and boost specific cytokines and improve the potency of macrophages and killer cells (7).  The macrophages and natural killer cells are specific immunological cells that go through the body and hunt for abnormal cancerous cells and cancer initiating viruses.  The more effective this part of the immune system is the less chance of cancer development, growth and metastasis.

Systemic enzymes work to modulate or coordinate the activity of various immune complexes and have no major adverse reactions (8).  They work as a lock and key mechanism and have an affinity for proinflammatory cytokines such as Tumor Necrosis Factor (TNF) and C Reactive Protein (CRP).  They also downregulate the overactivity of Tumor Growth Factor-Beta at the RNA and protein synthesis level.

Enzymes and Anti-Proteinase Activity:

Systemic enzymes are also known to bind irreversibly to antiproteinases such as α-2-macroglobulin and α-1-antitrypsin (9).  This leads to the synthesis of antiproteinases which inactivate other proteinases such as cathepsins which are thought to play a role in tumor development and metastasis.

The ratio of proteinases to antiproteinases is increasingly being used as a prognostic marker in oncology (9).  The cysteine group of proteinases such as papain and bromelain are known to influence the balance between proteinases and antiproteinases and influence tumor metastasis through this.

Enzymes interact with adhesion factors such as CD-44, CD-49, CD-54 and CD-58 which play a role in tumor growth and metastasis (10).  Enzymes also enhance antioxidant enzymes and reduce the amount of reactive oxygen species and free radical damage that initiates oncogene expression and development (11).

metastatic, How Does Metastatic Cancer Form in The Body?

Usage of Systemic Enzymes:

Systemic enzyme preparations are carefully formulated so they do not dissolve in the stomach acid and are able to get into the bloodstream fully intact.  The best systemic enzyme supplements use a variety of plant and animal enzymes.  Three powerful plant based enzymes include papain, rutin and bromelain while mammalian enzymes include trypsin, chymotrypsin and pancreatin.

Systemic enzymes are consumed on an empty stomach, enabling them to be absorbed into the blood stream to travel “systemically”, working throughout the body.  Systemic enzymes are protease enzymes that break down protein, and certain proteases have been shown to exhibit profound fibrinolytic and anti-inflammatory activity.


Enzymes and Intermittent Fasting:

Intermittent fasting used with systemic enzymes maximizes the benefit of both.  Intermittent fasting for periods of 16 -18 hours without any metabolically dynamic foods or drinks has been shown to improve the immune system and boost human growth hormone.  It also improves hormonal signaling in the body and stabilizes blood sugar and enhances fatty acid metabolism.

Systemic enzyme therapy must be done during periods outside of the digestive window.  An individual who is eating throughout the day will not have a long enough fasting window to effectively incorporate high dose enzyme therapy.

Most people do best when they use the morning hours to fast on water and cleansing beverages such as green drinks, herbal teas and lemon water.  This is the ideal time to use high dose systemic enzymes.  Additionally, it is always advisable to finish eating several hours before going to sleep for optimal digestion and immunity.  So using high dose enzyme therapy right before bed is another ideal window of delivery.


Enzyme Therapy Dosages:

Here are several protocols for using systemic enzymes.  When used in protocols for cancer, it is important to remember that extremely high doses may be warranted.  This is not meant to be a treatment protocol, but an idea of how many practitioners use systemic enzymes for various cancer cases.

Do not take anything written in this article or on this website as medical advice.  It is mean for information purposes only and the reader is 100% liable for any complications that occur by following or not following these suggestions.

Side effects to look out for with systemic enzyme usage would include nausea, diarrhea, dizziness, poor blood clotting or stomach pain.  If you notice any of these, stop taking the enzymes until the symptoms subside and then begin with a lower dosage and see if the symptoms return.

Anti-Inflammatory Lifestyle Protocol:

1-2 grams daily (4-8 caps)  divided into 1-2 doses

Cancer Prevention Protocol:

5 grams daily – 20 caps daily

10 caps in morning on arising

10 caps before bed

Cancer Patients:    Active Cancer in the Body: 

20-25 grams of systemic enzymes per day – 80 caps daily

30 caps first thing in morning on empty stomach

20 caps 3 hours later  (at least 2 hrs before/after food)

30 caps last thing at night before bed

Metastatic Cancer Patients:  Fast Growing Cancers 

Up to 45 grams per day –  160 caps daily

40 caps in morning

40 caps 2-3 hrs later (at least 2 hrs before/after food)

80 caps before bed

This article is for educational purposes only and due to FTC regulations we are unable to give specific medical advice.  With this said, if you want help with your health, we offer long-distance functional health coaching programs. We are unable to treat cancer, but we can put together programs to help support your overall health and provide guidance on various health strategies you are interested in applying on your health journey.

Sources For This Article Include:

1. Beard J. THE ACTION OF TRYPSIN UPON THE LIVING CELLS OF JENSEN’S MOUSE-TUMOUR: A Preliminary Note upon a Research made (with a Grant from the Carnegie Trust). British Medical Journal. 1906;1(2351):140-141.
2. Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014 Winter;20 Suppl 1:32-7. PMID: 24473984
3. Hale LP, Chichlowski M, Trinh CT, Greer PK. Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493
4. Li M, Bolduc AR, Hoda MN, Gamble DN, Dolisca SB, Bolduc AK, Hoang K, Ashley C, McCall D, Rojiani AM, Maria BL, Rixe O, MacDonald TJ, Heeger PS, Mellor AL, Munn DH, Johnson TS. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer. 2014 Jul 7;2:21. PMID: 25054064
5. NYU Lagone Cancers, Tumors & Blood Disorders Link Here
6. Kamenícek V, Holán P, Franĕk P. [Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling]. Acta Chir Orthop Traumatol Cech. 2001;68(1):45-9. Czech. PMID: 11706714
7. Sophie Lanone , Robert M. Senior, Jack A. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling. Elias Published August 15, 2002 . Citation Information: J Clin Invest. 2002;110(4):463-474.
8. Science-Based Medicine: Systemic Enzyme Therapy Link Here
9. Leipner J, Saller R. Systemic Enzyme Therapy in Oncology Link Here
10. Ween MP, Oehler MK, Ricciardelli C. Role of Versican, Hyaluronan and CD44 in Ovarian Cancer Metastasis. International Journal of Molecular Sciences. 2011;12(2):1009-1029.
11. Wassmann S, Wassmann K, Nickenig G. Modulation of Oxidant and Antioxidant Enzyme Expression and Function in Vascular Cells. Link Here

rashes, Skin Rashes: Symptoms, Causes and Natural Support Strategies

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  1. Great article, Dr. Jockers! I don’t see a particular enzyme recommended here, but heard you mention Wobenzyme on your interview podcast with Ameer Rosic. Would the Garden of Life Wobenzyme N supplement work for the enzyme therapy you mention above? Thank you!

    1. Is this still the one you recommend, Dr. Jockers? I just happened to have some it on hand.

  2. Hi Dr. Jockers, I first heard of you through watching your interview on the first Quest for the Cures conference. As a believer, I was very impressed and thankful that you mentioned God since so many in the natural/holistic world tend to leave God out of the equation. I’ve been following you on Facebook ever since. I am a 2 time cancer survivor and have been cancer free for about 2 years. Unfortunately, I used conventional methods because of lack of knowledge. Cancer was a gift from God as He opened up my eyes to the importance of health and nutrition. With God’s strength, I changed around my diet and lost over 100 lbs. I still have a ways to go. I’ve been thinking of adding enzymes to my supplement protocol. I heard Dr. Majors mention proteolytic enzymes tonight on the Natural Cures Summit and I was wondering if the systematic enzymes would be better or are they similar? Do the enzymes you recommend interfere with any other medication or supplement? Also, would I also need to purchase additional enzymes to take after I eat?

    1. Hey Kathy, thanks for writing. Praise God for your health results! Yes, Wobenzyme

      is the product I use and what Dr Majors was talking about. You take this between meals so it acts as a “systemic enzyme” rather than a digestive enzyme. It is highly adviseable to use a digestive enzyme whenever you are having solid foods and especially cooked foods too.

  3. Thank you so much for the links and your response. I realize how busy you are, and I truly appreciate you taking the time to respond. I’m planning on purchasing both of the enzymes. I’m on a variety of supplements including Lipo Gen since I don’t have a gall bladder as well as some prescribed medication (Lisinopril, Metformin, Levothyroxin- my weight loss has lowered these dosages). Will I be able to take the enzymes while taking all the other meds & supplements? I also wanted to do the maximized living cell & body detox. Can I do the enzymes & detox at the same time? I heard you need to detox in proper order- colon, liver, kidneys. Will the cell & body take care of it all at once? Thanks, Dr. Jockers, and God bless you for your heart and ministry to others. Your Facebook post this morning was a real blessing and reminder to me! I love your Sunday morning posts. God is so good it’s hard not to tell everyone about it! 🙂 I can’t wait for you interview in the upcoming conference!

    1. Hey Kathy,

      Yes you can take the enzymes and the Detox along with the meds, just not at the same time. Be sure to take those at differing times. Wobenzyme always between meals and Body Detox always at least 1 hour outside of meals or other supplements. Blessings!

  4. Hi Dr, Jockers

    For Someone dealing with a lower back sciatica pain how many enzymes per day would you recommend? Thanks

  5. Hi Dr. Jockers,

    I have been getting your informative weekly health newsletters for the past six months or so and read every article. I have even made some of your recipes and posted your site on my FB page. I first saw you on Quest for the Cure with Ty last fall. You give sound advice and solid information based on science and a belief that God created these amazing bodies for us. I agree wholeheartedly. I thought I was doing all the right things to achieve a healthy, happy body. Obviously and much to my surprise nothing could be further from the truth as I was diagnosed in August 2011 with Lymphomaplasmasitic Lymphoma, a rare blood cancer. I believe it is also known as Waldenstrom’s Macroglobulin Anemia.

    I have been interested in Enzyme Therapy for a little while and continue to read anything (reputable) that I can get my hands on. Would Enzyme Therapy benefit my situation since my cancer is in the blood? From August 2011 to June 2012, I had 31 rounds of chemo to bring my protein level down (IgM). My immune system of course suffered the consequences of the chemo and because of it, I have very little immunity fighting cells in my blood. With the help of my Naturopath, I have been trying to build it back up over the past two and a half years but so far nothing has really worked. Do you think high doses of enzymes would give my immune system a big boost so that eventually my own body would attack these cancer cells?

    Have you ever had the opportunity of conferring with any alternative care professionals in Canada? To be more specific…Toronto, Ontario? I am Canadian as you can probably guess by my last question. I was just wondering if you might be open to conferencing with my Naturopathic doctor? I know he would be open to a conversation. Please let me know if that is a posibility and I will make it happen.

    My IgM level is on the rise and I do not want to go through chemo again so if you have any suggestions I would be most grateful.

    I would like to congratulate you on your recent marriage. You make a beautiful couple. May God bless you both abundantly and thank you from the bottom of my heart for taking the time to listen.


    1. I am so sorry to hear about this Ida, I would highly recommend enzyme therapy for you with your condition. I would begin with 20 caps a day for 3 days (as described above) and if you are able to tolerate that well for a week (without stomach and digestive pains – most common symptoms of poor tolerance) than bump it up to 80 caps daily (if tolerated well) for 3 days than go up to 160 caps daily.

      Praying for healing! Blessings!

  6. Hi Dr. Jockers,
    Thank you for all of the information that you provide! Concerning buying enzymes such as Wobenzym and/or others for various therapeutic uses, how important is it for the enzyme activity to be listed instead of just the weight and/or amount?

    Thank you,
    Larry B

  7. Never mind–reference previous message concerning enzyme activity labeling. Upon closer examination of the Wobenzym N label, I see that there appears to be an enzyme activity standardization for each enzyme..based on Fib nomenclature????..and the source of each enzyme is also identified.
    Thank you.

    Larry b

  8. Hi Dr JockersI,

    First of all congratulations for your well researched articles. Just a quick question if I may. I’ve noticed that stearic acid and magnesium stearate are two fillers in the super-digest-zine you recommend. I read in several popular sites that those two fillers can interfere with the absorption of the active ingredient. I would be interested to hear your view on the matter.
    Thank you very much

  9. Hi Dr. Jockers,

    Thanks a lot for the link a very interesting read! Sorry I couldn’t find it using the search. I’ve noticed you have the soy lecithin in your “ingredients to avoid” list. Is that because of the estrogenic effect?

    The whey powder I take does contain it and spotted that the whey you sell has the sunflower lecithin instead.
    Thanks again

    1. Yes that is correct! I recommend staying away from soy due to the estrogenic effects and possible GMO aspect unless it is labeled as organic or non-GMO.

    2. Yes, I don’t recommend soy lecithen for the estrogenic effect and possible issues with GMOs if it isn’t organic. I recommend sunflower lecithen.

  10. Hi Dr, Jockers !
    I have a blader cancer. During the year, my tumor has not grown and I do not metastasize. I am using the Budwig protocol, baking soda and B17 as the main. As the main detox using coffee enemas. Now I started to take additional Wobenzym enzyme therapy: 80 caps daily 30 caps first thing in the morning on empty stomach
    20 caps 3 hours later (at least 2 hrs before / after food)
    30 caps last thing at night before bed.
    Question. How long should I take such enzymes? When should I use Cancer Prevention Protocol:
    5 grams daily – 20 caps daily
    10 caps in the morning on arising
    10 caps before bed

    1. Hey Viktors, you would want to work with a doctor to monitor the status of your cancer to determine when you can adopt a prevention protocol.


  11. Great to see this on enzymes and disease. Has anyone used systemic enzymes in dogs with cancer? Wondering if they would be same enzymes. Also above protocols do not account for weight. Any thoughts on dosage for a 55lb dog?

  12. Question, re: blood thinning affect of various Wobenzymn N dosage. I am Factor V Leiden on 2000 FU / day (one tablet) Nattokinese. My fish oil also is a thinner… I very much need info on dangers of combining various blood thinning products. I happily used Wobenzymn for many years with great result for my arthritis, later for cancer reduction, also great results!!. That was before I realized the blood thinning aspect of Wobenzymn. I’ve stopped Wobenzym since my doctor put me on Nattokinese following Factor V Leiden diagnosis…. I’d like to– and feel I NEED to — resume Wobenzymn, — if you can provide blood thinning information, please!!

  13. Hi Dr Jockers,

    Does the dosage you stated for active cancer that you apply to Wobenzym N? But Wobenzym N is in tablets, not capsules. So i’m not sure if it applies to Wobenzym N. Would appreciate it if you can clarify the dosage for Wobenzym N. Thank you so much.

    30 caps first thing in morning on empty stomach

    20 caps 3 hours later (at least 2 hrs before/after food)

    30 caps last thing at night before bed

  14. I have some questions about enzyme therapy for breast cancer.
    I plan to take 30+20+30 wobenzym pills a day (from your dosage) for 3 months to cure cancer. my questions are following…

    1. If I stop taking it in 3 months, my pancreas is affected by it? I don’t want to have digestion problem. I mean it might think , “I know need to make trypsin anymore because it’s given by wobenzym”.

    2. I think you mentioned that it’s ok to take wobenzym with lemon water. I want to be sure about it.

    3. If I take wobenzym with little protein meal, some wobenzym will be used to digest protein. But most of them can be used as a systemic enzyme? Do I need to take it only on empty stomach?

    4. I’m afraid of an enema. is there any alternatives? how about Charcoal?

    sorry for many questions…
    thank you!

    1. It should not affect your pancreas production of enzymes Cheon! It is fine to take with lemon water and I would definitely recommend taking the enzymes on an empty stomach! You could try something like Glytamins which are suppositories that can provide similar benefits.

  15. Hi Dr Jockers, I am on day 3 of a water fast and about to take high doses of enzymes for a condition called gynecomastia (male breast tissue). My dilemma is whether to just take the capsules with water or whether to empty the capsules and mix the powder in with the water. The reason I ask is because I am worried if I take the capsules that it will activate digestion and take me out of ketosis, but I’m also worried that if mix the powder in water then the enzymes might not reach the digestive tract?? Please help! 🙂

  16. Hello Dr. Jockers,
    I started having stomache problems roughly 3 weeks after starting Wobenzym. Although i followed directions and took it on an empty stomache I experienced nausea and throwing up, which was disappointing as I had better results from this than any of the presctiption medications I tried. I am wondering exactly what is the cause of these symptoms.
    Thank you

      1. I have started taking the Wobenzym with lemon water and have not had any of my former issues yet wonder if it’s hindering the effectiveness.

  17. Hi Dr Jockers
    Does enzymes have histamine in it? I have skin rash like hives if I eat pineapples or garlic. Will it go away eventually and should I keep eating these enzymes food?

  18. Can systemic enzymes cure an autoimmune disease such as Hashimoto’s? If so, what would the recommended dose be? Thanks!

  19. Hi Dr. Jockers. We’d love to buy some protealytic enzymes (husband has cancer Mets). But, I’m confused as you advised buying the Wobenzym brand. But. It looks like you sell your own as well. Please let me know which we should purchase. Thank you~

  20. My stepdaughter just diagnosed with b-cell lymphoma from biopsy of large ovarian tumor just removed. She has trouble swallowing – are there powder forms of the ingredients available? Or can Wobenzym N tablets be ground into powder? On another topic, I have sternal nonreunion 15 months after open heart with traditional wire closure, lots of clunk and grind. Surgeon says KLS talpon and JACE plates will help but I am not keen on another major surger, so he says bone won’t heal because of scar tissue, but over time fibrous tissue will build up to keep sternum fairly tight. Will Wobenzym N and/or serrapeptase interfere with this tissue buildup?

    1. So sorry to hear that! Yes they will help! I am not sure about grinding it into a powder as you want it to get into the intestines without being activated so it dosn’t irritate the stomach. We are praying for your step daughter!

  21. My father in law was just diagnosed with stage 4 stomach cancer and is after surgery of inserting a GJ tube into the upper stomach since the passage into duodnum is blocked. I would like to find out your take on Dr Gonzales’s protocol (originally dr Kelley’s) and also wanted to get your take on Wobenzym. Can my father in law take it since his these capsules will end up right at the tumior site and what dosage would you reccomend? We are beeing offered chemo, but are not comfortable with outcomes and are looking for alternatives. Thank you for your help.
    May God bless you.


  22. None of the suggested systemic protocols makes sense as they don’t explain how much of what enzyme one capsule contains.

  23. Dear Dr. Jockers,
    I’d like to start the cancer healing protocol, using Wobenzym N. Can I take the 80 tablets daily over a long period of time? In your experience, is there an average time frame where taking systemic enzyme usually starts showing results?

  24. Hi Dr. Jockers,
    Some of the links you added seem to questioning the healing effect of systemic enzymes, especially in regards to wobenzym.
    I’ve ordered your proteo enzymes and was wondering why you’re not taking your own product and instead use wobenzym for yourself.

    Kind regards

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