Systemic Lupus: Symptoms, Causes and Support Strategies
The inflammatory autoimmune disease that affects multiple organs and connective tissue in the body including the heart, brain, lungs, joints, blood vessels, skin and kidneys among others is called Systemic Lupus Erythematosus (SLE). Conventional medical treatment for lupus involves high dose corticosteroids which suppress the immune system and presents numerous other side effects.
This article will provide you with information on how to treat the inflammatory effects of autoimmune diseases such as lupus naturally. In addition, you will learn why it is important to avoid the dangers of immunosuppressant drug treatments, if possible, and address the root causes of the disorder. In this article, you will learn the most common symptoms and root cause factors for systemic lupus as well as natural support strategies.
Symptoms of Lupus:
Skin lesions afflict 90% of individuals with lupus such as is evident by the butterfly-shaped rash present on an afflicted individual’s face (24). The rash covers the cheeks and the bridge of the nose. Common signs of lupus include arthritic changes, chronic fatigue, joint pain, headaches, mouth sores and reduced white blood cell count. (2)
Advanced neurodegenerative symptoms of the disease include memory loss, confusion, anxiety and depression. Lupus patients are also prone to cardiodegenerative symptoms including anemia, high blood pressure, heart disease, shortness of breath, seizures and stroke. (21)
SLE carries a wide range of clinical symptoms which can be mild or life threatening making diagnosis often a complicated and prolonged process.
Who Is Affected by Lupus?
Sex matters in the risk of developing lupus as this chronic autoimmune disorder affects 9 women for every 1 man. Individuals at an increased risk for lupus also include individuals of Asian or African descent, individuals at reproductive ages between the late teens to early 40s and has the highest prevalence in Italy, Martinique, Spain and the British African-Caribbean population. (22)
Researchers hypothesize that factors which trigger the worsening effects of lupus are predominantly characterized by women’s hormones like estrogen and hormonal fluctuations caused from stress and pregnancy affecting the immune system (15). Individuals with a family history of an autoimmune disease have an increased risk of developing the disorder.
Environmental risk factors include those with increased exposure to toxins and poor diets. For example, a diet high in processed foods increases the inflammatory state of the body, increasing risk for autoimmune complications such as food allergies and gastrointestinal disturbances.
Boost Your Body’s Immunity:
Restoring your body’s natural defenses to properly respond to a threat is crucial to overcoming chronic inflammatory disorders. People with such disorders have immune systems that are in a constant and overwhelming state of heightened reactivity which triggers inflammation. Here are 12 factors that you can address to better regulate immune function.
Gut Dysbiosis: This condition of the digestive tract is characterized by an imbalance of microbes, commonly an overgrowth of pathogenic bacteria. This imbalance results in chronic inflammation and can lead to leaky gut syndrome (5). In order to heal the immune system, optimizing gut health is key.
Methylation: Methylation is an important biological process in epigenetics. Methylation protects DNA, signals genes on and off and aids to detoxify cells of hazardous chemicals. Many people lack proper methylating abilities because of a specific genetic mutation that inhibits this function. Methylation is critical in boosting your body’s natural immune defenses because it also is used in regulating T cell function (6).
EMF Exposure: EMF exposure, or electromagnetic frequency, has been found to create immune system dysfunction. Exposure to EMF is thus associated with a higher risk of developing an autoimmune condition (7). Doing your best to reduce EMF exposure and getting grounded by going barefoot on grass, dirt or sand for at least 10 minutes each day can make a big difference.
Poor Blood Sugar Regulation: Balancing blood sugar is essential for a healthy immune system. Unstable blood sugar levels promotes an increased response by the immune system working overtime to support the body’s energy needs causing altered signaling pathways and dysfunction.
Mitochondrial Dysfunction: Mitochondria are energy producing “powerhouses” for each cell in the human body which are susceptible to high levels of oxidative stress daily. Abnormal mitochondria function is associated with increased free radical damage and oxidative stress.
Glutathione Deficiency: Glutathione is a master antioxidant present within every cell in the human body. Glutathione is needed to support white blood cell (WBC) function. WBCs are susceptible to high amounts of oxidative stress resulting from free radical damage every single second. A glutathione deficiency can exacerbate inflammatory levels and potentially lead to autoimmune conditions (9).
Environmental Toxins: Environmental toxins upset the gut microflora, reduce glutathione levels and trigger inflammatory activity in the body (10, 11, 12). The human body is regularly exposed to such toxic agents found in pesticides, herbicides, plasticizers, personal care products, and heavy metals as well as infectious microbes and biotoxins like mold which deplete glutathione levels.
High Stress and Poor Breathing Habits: Mental and emotional stress elevates the production of stress hormones in the body. These hormones produce inflammatory effects. Coupled with short and shallow breathing habits throughout the day, these stressors induce mental and emotion stress at the physiological level (13).
High Omega 6:3 Ratio: The ratio of omega 6 fatty acids to omega 3 fatty acids is critical in understanding chronic inflammation and autoimmunity (14). On average, most people have a higher concentration of omega 6 fats compared to omega 3 fats. The higher the concentration of omega 6 to omega 3 fats, the increased release of pro-inflammatory mediating prostaglandin molecules.
Sleep Deprivation: Up to 80% of lupus patients are not receiving enough sleep and suffer from chronic fatigue (23). Poor sleeping habits promotes immune dysfunction and chronic inflammation. Adequate sleeping habits are essential to melatonin secretion responsible for reducing inflammation and tissue repair (15).
Vitamin D Deficiency: People who are deficient in vitamin D (have levels lower than 40 ng/ml) are significantly more likely to develop chronic inflammation and autoimmunity (16).
Upper Cervical Subluxation: The occiput which is the bottom of the skull and the atlas, the first bone, both play a key role in the information coordinated between the brain and immune system. Subluxation at this joint creates a rotation to the top of the spinal cord resulting in compression and increased inflammation in the body (17).
The Microbiome and Lupus:
The gut plays a major role in the health of the immune system because it supports nutrient absorption and detoxification. More than 1000 unique species of bacteria make up the gut microbiome. An overgrowth and depletion of certain bacteria is evident in individuals with lupus. Researchers have found that individuals with low levels of beneficial Lactobacilli and bifidobacterium and increased levels of the butyrate producing Lachnospiraceae were present in the early onset of lupus development (4).
Individuals with lupus are recommended to take a daily probiotic and consume probiotic rich foods. Adding healthy probiotics rich in Lactobacillaceae bacteria can exhibit anti-inflammatory effects by suppressing pro-inflammatory T cells and interleukins and stimulating Treg cells to regulate immune cell homeostasis. (4)
Raw and organic vegetables are also an excellent choice to heal gut issues. Avoiding unnecessary toxins is required to balance gut flora, improve digestive motility, remove toxins and reduce inflammation. Raw vegetables improves homeostasis by promoting an alkaline environment that is not susceptible to disease.
Prescription Drugs Influence Microbiome:
Unfortunately, many prescription medications used to manage lupus symptoms include immunosuppressive drugs which can increase the microbial imbalance in the gut. Drugs like Cytoxan (cyclophosphamide) and Rheumatrex (methotrexate) suppress inflammation by reducing the body’s own ability to fight off infection.
Steroidal drugs cause a variety of side effects which can also upset the microbiome and have damaging effects comparable to antibiotics. In fact, researchers have found that certain drugs promote a bacterial environment within the gut that despite not being classified as pathogenic, can still promote arthritic symptoms in autoimmune diseases (3). Individuals genetically predisposed to lupus are also more likely to harbor commensal gut bacteria which promote autoimmunity (19).
Anti-Inflammatory Diet and Lifestyle:
A lifestyle supplemented with anti-inflammatory foods and exercise can help to naturally treat lupus. Poor digestion resulting from a diet with reactive and inflammatory foods puts the body in a hyperimmune state that is highly reactive. Such a disruption can further create hormonal upset, toxicity and essentially a weakened immune system.
Some of the risk factors for lupus include a diet limited in adequate nutrients, food allergies and sensitivities, and gastrointestinal disturbances which may manifest as leaky gut syndrome. Individuals with lupus should consider regular low-intensity exercise to reduce symptoms such as depression, fatigue and improve cardiovascular fitness and overall health.
Treat lupus symptoms naturally by consuming a diet full of anti-inflammatory foods and healthy fats such as coconut oil, avocados, olives, vegetables, herbs and wild caught fish like salmon and sardines. Supplements to consider in the treatment of lupus include vitamin D, fish oil, b vitamins and probiotics. (1)
One of the best approaches for individuals with lupus is to follow an elimination diet where you eliminate the most common food irritants and any other suspicious foods for a few weeks and then slowly and intentionally add them back in in order to see if they trigger an inflammatory reaction. This article goes into more detail on this.
Foods and Activities to Avoid:
People with lupus should avoid foods hard to digest such as gluten and legumes. Foods which can increase inflammation in the body such as sugar, trans-fat, alcohol and caffeine should also be limited if not avoided. To reduce symptoms of lupus it is beneficial to consume 1 to 2 cups of bone broth daily.
Individuals with lupus should limit exposure to the sun as ultraviolet rays can trigger an autoimmune reaction. They should still aim to get 15 minutes of quality sunshine daily as that level is very beneficial for the immune system. However, try to avoid more than 30 minutes of direct sunshine as this can cause skin inflammation and a butterfly rash reaction for individuals with lupus.
Incorporating certain foods into your diet is an excellent way to improve the moisture of your skin. Healing foods that provide relief from dry and irritated skin from the inside out include coconut oil, avocado, green tea, cucumbers and omega 3 rich walnuts, almonds and flaxseeds. Patients who smoke are strongly advised to quit as this habit increases the strain on the cardiovascular system and can exacerbate symptoms of lupus. (1)
One supplement that can be very helpful for individuals with lupus is a good quality bone broth or collagen protein which provides key amino acids that support the gut and the tissues that are most commonly affected by lupus.
Mitochondrial Dysfunction and Lupus:
Mitochondria are present within each cell to supply the body’s energy demand. These powerhouse organelles are major sites of oxidative stress due to the high production of reactive oxygen species ROS (reactive oxygen species) and RNS (reactive nitrogen species). Each promotes free radical damage and further oxidative damage to cells and tissue resulting in chronic inflammation and autoimmune symptoms.
Prolonged increased stress to cells depletes the body’s biological abilities to protect against oxidative damage. Mitochondrial dysfunction in lupus patients is associated with reduced glutathione and SOD (superoxide dismutase) levels as well as abnormal energy production. (20)
Natural Support Strategies For Healthy Inflammation
Here are the best action steps to get started with on your journey to improve your inflammatory response. These strategies are not at this time FDA approved to prevent, mitigate, treat or cure systemic lupus and should not be confused as such. You should always consult with your physician before stopping or changing medications or taking on new health strategies.
Additionally, you should be working with a functional health practitioner to help guide you through these strategies. This is not an exhaustive list and there are other natural therapeutic strategies that I and functional health practitioners will utilize to help individuals with rheumatoid arthritis.
Good nutrition is always important for any health condition. There are foods that can cause inflammation and intestinal permeability, both of which contribute to various health problems.
An anti-inflammatory, healing diet removes foods that cause inflammation and damage the gut lining. Instead, your diet should include organic, non-GMO vegetables, fruits, healthy fats, and clean protein. This will help to reduce inflammation, stabilize your blood sugar, reduce your toxic load, and support healthy blood pH levels.
Many people with Lupus have nutrient deficiencies. An anti-inflammatory healing diet is nutrient dense and will help to supply your body with the nutrients it needs.
Foods to Avoid With Lupus
It is important to avoid highly inflammatory foods. Pro-inflammatory foods include:
- Refined sugars and grains (and any foods that are easily metabolized into sugar)
- Conventionally raised meat and dairy products
- Gluten-containing foods
- Farmed fish
- Processed foods
- Highly processed vegetable and seed oils, such as canola, grapeseed, and safflower
- Foods with additives and preservatives
Foods to Include
The foods you should be eating on an anti-inflammatory, healing diet are whole, unprocessed foods. Choose grass-fed and pasture-raised meats and wild-caught fish. Include a variety of low to moderate carbohydrate, lower glycemic, colorful vegetables and fruits for their abundant antioxidants and phytonutrients. Plentiful amounts of herbs are a powerful addition to a healing diet.
Healthy fats are a very important part of a healing diet. Healthy fats are found in coconut, olives, avocados, and their oils and in grass-fed butter and ghee. Omega-3 fatty acids and conjugated linoleic acid (CLA) found in wild caught salmon and grass-fed beef and dairy are fats with many health benefits. These healthy fats are an efficient source of fuel for the body to combat inflammation.
Test For Food Sensitivities:
Most people with autoimmune conditions have leaky gut and food sensitivities. These sensitivities can be hard to pinpoint as they result in delayed symptoms that are not life threatening.
The most common food sensitivities include gluten, corn, dairy, soy, peanuts and sugar. Some other potential food sensitivities to consider include all grains, eggs, nuts, seeds and nightshade vegetables (tomatoes, potatoes, peppers and eggplant).
It can be helpful to do a 28 day elimination diet where you remove all of these and then slowly add these back in one at a time. You can also do both biofeedback and blood testing to determine what foods are causing stress in your system and an elimination diet to test how you are responding to eliminating certain foods for periods of time. You can also
Intermittent fasting is a form of fasting cycles between not eating (fasting) and eating (feasting) over a period of time. The benefits of intermittent fasting benefits include cellular repair, autophagy, immune regulation, inflammation levels, and insulin sensitivity.
It also helps to lower the risk of developing autoimmune and chronic inflammatory conditions such as Lupus. Going 16–18 hours between dinner and breakfast is one of the best ways to improve mitochondrial production. Your body improves energy efficiency by increasing and strengthening the mitochondria during periods of fasting. Consume your meals in a 6-8 hour window such as 11am–7pm or 12–6pm.
When you do this you enhance cellular healing and joint cell regeneration. Fasting also helps enhance regulatory T cells which calm the immune system and keep inflammation under control (18). To learn more about the benefits of intermittent fasting and best intermittent fasting practices, I recommend this article.
Reducing stress is a critical for reducing inflammation and improving immune health. I recommend that you reduce stressors from your life as much as possible. Turn off the news, and only look at it once a day or a few times a week for a specific period. Reduce your social media use and time on the internet.
Avoid people and situations that bring you down. Surround yourself with loving and uplifting people. Engage in uplifting and relaxation-promoting activities. Read, try some arts and crafts, play cards or board games, sing, and dance.
Spend time in nature and do some grounding walking barefoot on grass. Practice daily gratitude and try positive affirmations. Practice self-love and laugh with friends and family. Meditate, pray, journal, and try daily breathing exercises. Be grateful and smile more.
Improve Your Sleep:
Prioritizing good sleep is just as important as reducing your stress levels. Develop a regular schedule going to bed and getting up at the same time every day to support your circadian rhythms.
Avoid electronics, sugar, caffeine, heavy foods, and stress close to the bed. Engage in relaxing activities, including stretching, relaxing baths, meditation, and prayer. Make sure that you have a supporting bed, pillow, and bedding, and sleep in a dark calming room.
Include Magnesium & B Vitamin Rich Foods:
Magnesium helps to improve blood sugar signaling patterns and improves mitochondrial health. The best magnesium and B vitamin rich foods include dark green leafy veggies, avocados, grass-fed animal products, raw cacao and pumpkin seeds.
You can also do Epsom salt baths to support your magnesium levels. It would also be wise to supplement with a good magnesium and B complex supplement. Look for magnesium L-threonate which is the best form of magnesium for crossing the blood brain barrier.
When it comes to B vitamins, it is best to look for one with pre-activated forms such as methyl-folate, methyl-cobalamin (B12), Pyridoxal-5-Phosphate form of B6, and Riboflavin-5-phosphate form of vitamin B2. The methyl groups are in the active form and will be better utilized by the body.
Focus on Deep Breathing:
Improving your posture, seeing a high quality chiropractor and optimizing your breathing patterns is highly recommended. Taking time to slow down your breathing and take long-deep breaths for a few minutes every hour will help reduce the sympathetic, fight or flight part of the nervous system.
The better we breathe, the better we will heal and the more blood flow we will get and the better our immune and inflammatory health will be. Follow these tips here to improve your breathing patterns.
Use Anti-Oxidant Rich Herbs:
Carminatives are herbs that help to improve digestive health by reducing pathogens in the gut, stimulating the production of stomach acid, bile and pancreatic enzymes and modulating the gut microbiome.
Examples of these herbs include turmeric, ginger, oregano, garlic, basil, thyme and rosemary. These herbs are help to improve digestion, reduce inflammation and support a healthy brain. There are a number of ways to use these that I discuss in the following image. I like putting the herbs on foods, using herbal teas, fermented foods and essential oils.
Ground Your Body:
In our society we are surrounded by toxic electromagnetic frequency’s (EMF’s). These EMF’s increase stress and inflammation within the body and can be a trigger for autoimmune activity for some individuals.
By going outside daily and walking barefoot on grass, dirt or sand you absorb natural EMF’s from the ground that balance your electrical rhythms. Follow the steps in this article here.
Supplement With Omega 3’s:
Omega 3 fatty acids and in particular the long chain variety EPA and DHA are critical for stabilizing blood sugar, reducing inflammation and autoimmunity improving joint health. Consume grass-fed meat, grass-fed butter, wild-caught fish, seafood and spirulina to get it in your diet.
Plant based omega 3’s such as flax oil only contain the small chain omega 3 called ALA and do not have any DHA. It is very hard for our body to convert ALA into DHA so it is best to get a high quality fish or krill oil that is rich in EPA and DHA. You want to find a brand that is molecularly distilled to take out any heavy metals and other unwanted contaminants.
Be sure to discuss with your physician before using as fish oils have a blood thinning affect and can be contraindicated if you are on blood thinning medications.
Improve Your Mitochondria:
The mitochondria are the energy powerhouses of every cell. When someone has an autoimmune disorder it is a clinical sign that they have dysfunctional activity going on in the mitochondria.
Support your mitochondria with clinical doses of CoQ10, L-carnitine, N-acetyl cysteine, creatine monohydrate, B vitamins, magnesium, alpha lipoic acid and D-ribose. You can find mitochondrial support supplements that have most if not all of these key nutrients.
Optimize Your Vitamin D:
Low vitamin D3 is associated with chronic inflammation and autoimmune conditions. Vitamin D is arguably one of the most powerful nutrients responsible for modulating and coordinating the immune system.
In autoimmune disease, the immune system has a hard time differentiating self from non-self (foreign invaders). Vitamin D helps the immune system make this important distinction, which reduces autoimmune disease formation (25). Vitamin D also helps to modulate the immune system to reduce inflammation throughout the body (26).
Support Gut Health
In order to reduce inflammation and autoimmunity, you have to repair and heal your intestinal lining. I recommend eating a gut friendly diet that works best for your body type. For some individuals with RA, a low oxalate diet is very helpful.
Consuming liquid nutrition for is great for stimulating the digestive process, increasing nutrient absorption, and improving gut health. Liquid nutrition does not require as much energy to digest, so your body can focus on healing and repair. You can combine liquid nutrition with fasting strategies for quicker healing.
Using a good quality bone broth collagen in a shake or smoothie is a great way to include liquid nutrition in your diet. Collagen contains amino acids, including glycine and glutamine, which are essential for healing leaky gut. These amino acids seal the holes in the gut by healing damaged cells and building new tissue. Collagen also makes up the villi, small finger-like structures on the intestinal wall and assists with water absorption in the intestines.
Additionally, I recommend taking a daily probiotic supplement. Probiotics helps to optimize your gut health and improve your nutrient absorption while reducing gut related inflammation. When gut inflammation goes down it also reduces inflammatory mediators that impact joint health.
Reduce Toxin Exposure
Reducing your toxic exposure is critical for improving liver function and reducing inflammation. Buy organic food as much as possible. Stop using conventional beauty, body, and household products, and replace them with organic, natural, or homemade alternatives.
Use glass, stainless steel, wood, and bamboo products instead of plastic. Spend time in nature and breathe in the fresh air. Use a good indoor air filtration system. Make sure that you drink clean, toxin-free water by using a high quality reverse osmosis system. Add a slice of lime and pinch of salt for some extra flavor, electrolytes and antioxidants.
Support Detoxification Pathways
It is not enough to put good things into your body, you have to make sure that the bad things come out as well. Drink plenty of water to support detoxification through sweating and urine. Support your detoxification pathways to protect your body from brain inflammation.
I recommend using infrared saunas to promote detoxification through sweating. Try rebounding and dry-skin brushing to support your lymphatic pathways. Support two major detoxifying organs, your kidneys and liver with herbs like milk thistle, parsley, dandelion and bioactive carbons which can penetrate and remove toxins from deep within the tissues and cells.
Rheumatoid arthritis is a serious issue that affects millions of people around the world. The symptoms of RA include joint pain, impaired joint function, fever, weight loss, anemia and fatigue. To protect yourself from chronic inflammatory and autoimmune conditions, follow the recommendations in this article. You may notice improvements in your pain, energy and overall health.
If you want to work with a functional health coach, I recommend this article with tips on how to find a great coach. At my clinic, we offer long-distance functional health coaching programs. For further support with your health goals, just reach out and our fantastic coaches are here to support your journey.