Endometriosis: Causes and 13 Natural Treatments

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endometriosisEndometriosis: Causes and 13 Natural Treatments

Endometriosis is a painful condition where the tissue that normally lines the uterus grows outside of the uterine cavity. This displaced endometrial tissue leads to cysts, scar tissue, and adhesions. Endometriosis is a chronic and debilitating disease that affects around 10% of all women of reproductive age.

Symptoms of endometriosis include pelvic pain, especially during your period, pain with intercourse, pain with bowel movements or urination, irregular (and often heavy) periods, fatigue, and infertility. Women with endometriosis may have gastrointestinal symptoms such as bloating, IBS, constipation, and nausea. Endometriosis also increases a woman’s risk of developing ovarian cancer.

There are different theories as to the cause of endometriosis, but the exact etiology is unclear. Inflammation, hormonal imbalances, blood sugar imbalances, bacteria, and environmental toxins are factors that have been shown to contribute to the development and progression of endometriosis.

Conventional treatments for endometriosis are often ineffective and have negative side effects. Fortunately, there are numerous natural strategies to prevent and improve endometriosis.

What is Endometriosis?

Endometriosis is a condition where the tissue that makes up the lining of the uterus is found throughout the pelvic cavity. The tissue can be found on the ovaries, ligaments, bladder, bowel, and the peritoneum (the lining of the abdominal cavity that covers your organs). This tissue causes chronic, inflammatory reactions that can lead to extreme pain and scarring (1).

Endometriosis can spread to other areas of the body such as the gastrointestinal or respiratory tracts. Endometriosis often occurs with adenomyosis, a condition where endometrial cells grow into the uterine wall.

It is estimated that 176,000,000 women worldwide have endometriosis (2). This condition affects around 10% of women of childbearing age. Postmenopausal women with high estrogen levels can also develop endometriosis.

Symptoms of Endometriosis

The most common, and usually the first, symptom of endometriosis is pelvic pain. Women with endometriosis have very painful periods, along with pain before and after periods. Their periods are often irregular, and they may have spotting and bleeding between cycles.

Other common symptoms of endometriosis are fatigue, pain during bowel movements or urination, pain with intercourse, joint and nerve pain, and gastrointestinal symptoms such as irritable bowel syndrome (IBS), nausea, bloating, and constipation.

One of the most difficult symptoms of endometriosis is infertility. Adhesions within the ovaries can cause infertility, even if it is a mild case of endometriosis. Around 30-40% of women with endometriosis will experience fertility problems, and around 50% of women who are experiencing infertility have endometriosis. Endometriosis is also associated with an increased risk of ovarian cancer.

How is Endometriosis Different from PCOS?

While endometriosis is affected by hormones, it is not a hormonal condition like premenstrual syndrome (PMS) or polycystic ovarian syndrome (PCOS). The symptoms of endometriosis and PCOS can often overlap, and women commonly suffer from both conditions. But, there are clear distinctions between the two diseases to help determine which condition(s) you have.

PCOS is due to hormonal imbalances. This disorder is characterized by inflammation, insulin resistance, and an overproduction of male (or androgenic) hormones.

PCOS is diagnosed when women have irregular or no periods and fail to ovulate, high levels of androgens, and enlarged ovaries containing multiple small follicles (polycystic ovaries). Symptoms of PCOS are irregular periods, weight gain, abnormal hair growth (such as the face), thinning hair on the head, acne, and difficulty getting pregnant.

Both endometriosis and PCOS cause irregular periods that are heavy and painful. Skin issues, abnormal hair growth, chronic pelvic pain, and infertility are common with both conditions.

Factors that Contribute to Endometriosis

The exact mechanism for the development of endometriosis is not clear. Scientists have proposed many possible explanations, including genetics, surgical scar implantation, transformation of peritoneal cells or embryonic cells, transport of endometrial cells, and retrograde menstruation. Retrograde menstruation is when menstrual blood flows back through the fallopian tubes and into the pelvic cavity instead of outside.

Another possible cause is a disordered immune system. A woman’s immune system may make her body unable to recognize and destroy endometrial tissue that is growing outside of the uterus.

Despite there not being a clear cause, there are numerous factors that may contribute to endometriosis. These factors include inflammation, hormonal imbalances, blood sugar imbalances, bacteria, and toxins. Addressing these factors is critical for improving endometriosis.

Chronic Inflammation

Endometriosis is often characterized as a disease of inflammation. The body’s immune reaction to having endometriosis is to develop inflammation and estrogen proliferation promotes inflammation.

Inflammatory cytokines and inflammatory mediators are present in the peritoneal fluid of women with endometriosis. Cytokines are small proteins secreted by your immune system that act as chemical messengers. These cytokines regulate the immune response by facilitating cell to cell communication and stimulating the movement of cells towards sites of infection, trauma, and inflammation. Researchers have found imbalances in these cytokines in women with endometriosis.

Interleukin-1 (IL-1) are pro-inflammatory cytokines that are involved in the development of endometriosis. Studies show that IL-1aresignificantly increased in the peritoneal fluid and endometrial cells of women with endometriosis (3).

IL-1 receptor antagonist (IL-1RA) acts as an anti-inflammatory cytokine. IL-1RA is a natural regulator of IL-1. This inhibitory cytokine is reduced in women with endometriosis. This imbalance between IL-1 and IL-1RA may contribute to the unrestricted growth of endometriosis.

Hormonal Imbalances

Endometriosis depends upon estrogen. Estrogen plays a crucial role in both the development and maintenance of endometriosis.

Hormonal imbalances, such as estrogen dominance, can lead to endometriosis. Estradiol (E2) has been found to regulate and promote the growth of endometriosis (4). Low progesterone levels can also contribute to higher levels of estrogen in your body.

Blood Sugar Imbalances

Imbalances in blood sugar can contribute to endometriosis. When you eat foods high in sugar or refined carbohydrates, insulin is released. Spikes in insulin are associated with lower levels of Sex Hormone Binding Globulin (SHBG). SHBG binds to excess estrogen and testosterone in the blood.

When SHBG is low due to spikes in insulin, levels of estrogen and testosterone increase. Insulin also increases the production of testosterone, which is converted to even more estrogen by belly fat. Higher levels of estrogen promote the growth of endometriosis.

Blood sugar imbalances are also a stress on the body and cause the release of adrenaline and cortisol. Cortisol and progesterone are made from the hormone pregnenolone. When the body needs cortisol, the production of progesterone is sacrificed. This leads to higher levels of estrogen which can contribute to endometriosis.

High Bacterial Load

A new concept called the “bacterial contamination hypothesis” was recently proposed for endometriosis. This hypothesis is based on the finding that women with endometriosis have a high level of gram-negative bacteria and the bacterial toxin lipopolysaccharide (LPS) in their pelvis (5). LPS is a potent endotoxin that causes an inflammatory reaction.

These bacteria could both be the effect of endometriosis and a cause of endometriosis. For management and prevention of endometriosis, probiotics applied intravaginally or orally may be helpful. Probiocharge 100 has a clinically effective dose of very powerful probiotic strains to improve nutrient absorption, immune development, and toxin elimination.

High Toxin Load

Environmental toxins such as dioxins, pesticides, polychlorinated biphenyls (PCBs), and phthalates are endocrine disrupting compounds (EDCs). Exposure to these toxins wreaks havoc on your hormones and contributes to endometriosis.

Xenoestrogens are artificially created compounds that mimic the effects of estrogen and interact with cellular receptor sites. Xenoestrogens contribute to excess estrogen and lodge in fat cells where they are resistant to breakdown. This effect is enhanced when xenoestrogens are combined with other EDCs, producing symptoms of estrogen dominance.

It is critical for healthy hormones to minimize your exposure to EDCs. You should avoid conventional meat and dairy, soy isoflavonoids, sugars, additives, preservatives, grains, beer, and processed foods.

Plastics are one of the main culprits of EDCs. Plastics contain xeno-estrogenic chemicals such as BPA. These dangerous toxins leach into the water or anything heated in plastic.

Conventional Treatments for Endometriosis

There are several options for the conventional treatment of endometriosis including surgery, hormone suppression drugs, intrauterine device, and management of pain with medications. These methods can be ineffective and have undesirable side effects.

Surgical removal of the lesions is the first-line intervention. Unfortunately, there is a high rate of recurrence (about 50% within 5 years). Doctors often prescribe medications to reduce pain such as anti-inflammatory drugs (NSAIDS) and opioids.

Hormonal suppression drugs like birth control pills or Lupron are prescribed to shut down ovulation and induce estrogen deficiency. Estrogen deficiency may slow the growth of the tissue, but it does not cure the condition. These treatments cannot be used over long periods of time due to severe adverse effects such as depression and bone loss.

An intrauterine device (IUD) can be inserted to suppress the uterine lining and endometriosis lesions. This method does not suppress ovulation or cause estrogen deficiency. However, there are many negatives to IUDs.  Fortunately, there are many natural strategies for endometriosis without all of the negative side effects.

Natural Strategies to Prevent and Improve Endometriosis

Natural strategies for endometriosis improve immune function and reduce inflammation. The strategies we focus on include an anti-inflammatory diet, stress reduction, and key supplements. The list below is not an exhaustive list but it is a great place to begin when looking to heal from this disorder.

As always, we recommend working with your doctor and a functional health practitioner to customize the right plan for you.  If you need to find a good functional health practitioner than this article will give you tips on how to find the right one for you.

Anti-Inflammatory Healing Diet

One of the best strategies for preventing and improving endometriosis is to consume an anti-inflammatory, healing diet. This nutritional strategy removes foods that cause inflammation and includes anti-inflammatory foods like organic, non-GMO vegetables, fruits, healthy fats, and clean protein.

This healing diet reduces inflammation, stabilizes blood sugar, reduces toxic load, provides necessary nutrients, and supports healthy blood pH levels.  The first 3 steps include taking out grains and high sugar and starchy foods that drive up blood sugar levels, avoiding damaged fats and focusing on eating healthy fats and looking for organic, pasture-raised animal products.

Foods to Avoid

Endometriosis is an inflammatory condition, so it is critical to avoid highly inflammatory foods. Pro-inflammatory foods are refined sugars and grains, and any foods that are easily metabolized into sugar (high glycemic foods). These foods upregulate inflammation and create extra acidity in the tissues.

Conventional dairy products and gluten should be avoided if you have endometriosis. Gluten and A1 casein, a protein found in conventional dairy, stimulate the release of inflammatory cytokines and affect immune function. One study showed that after 12 months on a gluten-free diet, 75% of participants with endometriosis had significantly less pain (6).

Meat and dairy from conventionally-raised animals and farmed fish should be avoided. As discussed above, these foods contain endocrine disruptors such as hormones, steroids, pesticides, GMOs, and antibiotics.

Processed foods contain toxic additives and preservatives. Processed vegetable oils, such as canola, grapeseed, and safflower, promote inflammation and should also be eliminated.

Foods to Include

The foods you should be eating on an anti-inflammatory, healing diet are whole, unprocessed foods. It is important to eat organic foods because pesticides can affect estrogen and other hormones.

Choose grass-fed, pasture-raised, wild-caught meats and fish. Enjoy a variety of lower carbohydrate, low glycemic, colorful vegetables, and fruits for their abundant antioxidants and phytonutrients. Plentiful amounts of herbs are a powerful addition to a healing diet.

Including a variety of relatively low-carbohydrate vegetables is an important part of an anti-inflammatory diet. Cruciferous vegetables such as broccoli, cauliflower, cabbage, kale, bok choy, and Brussels sprouts contain high levels of phytoestrogens that act like vitamins for endometriosis. These vegetables compete to occupy estrogen receptor sites to prevent estrogen from exerting its effects on the cell.

Low glycemic fruits include berries, lemons and limes, grapefruit, and granny smith apples. Berries and apples are high in powerful antioxidants called polyphenols.

Healthy fats are a very important part of a healing diet. Healthy fats are found in coconut, olives, avocados, and their oils and in grass-fed butter and ghee. Omega-3 fatty acids and conjugated linoleic acid (CLA) found in wild caught salmon and grass-fed beef and dairy are fats with many health benefits. These healthy fats are an efficient source of fuel for the body to combat inflammation.

Correct Hormonal Imbalances

When progesterone declines from the natural aging process or from high levels of chemical, physical and emotional stress, this causes estrogen dominance. Endometriosis is one of the numerous symptoms of estrogen dominance, along with hot flashes, fatigue, weight gain, thyroid issues, PMS, and much more.

There are several supplements that can help eliminate xenoestrogens from your body and encourage healthy estrogen metabolites.

EstroProtect uses a dual-action approach to balance estrogen metabolites. It contains diindolylmethane (DIM) and sulforaphane glucosinolate (SGS) to support phase I and II of estrogen metabolism. This supplement can help balance estrogen and progesterone, restore proper estrogen metabolite ratios, improve hormonal function, and reduce symptoms of estrogen dominance.

Supplementing with vitamin B6 can help boost progesterone to balance excess estrogen. Vitamin B6, along with vitamins B1 and B2, assists liver enzymes in removing excess estrogen from the body.

Additionally, certain herbs such as Chaste Berry extract, parsley, dandelion, Don Quai and ginger all work great to relieve menstrual pain and improve the female hormone balance.  We put together a specific supplement called PMS Peace which contains therapeutic dosages of all of these key nutrients and more.  I use this with all of my patients dealing with endometriosis and other menstrual related complaints.

Balance Blood Sugar

It is important to balance your blood sugar to balance your hormones. Poor blood sugar control leads to elevated insulin and cortisol which can cause the release of estrogen. These factors also lead to deficiencies in magnesium, vitamin C, and vitamin B6 which are important for neutralizing bad estrogen metabolites in the liver.

Consuming an anti-inflammatory diet eliminating sugars and refined carbohydrates is critical to balancing blood sugar. Certain nutrients also help stabilize blood sugar levels.

Insulin Manager has a blend of nutrients that support healthy blood sugar and reduce inflammation, including fenugreek, Gymnema, bitter gourd, vanadium, B vitamins, and chromium. The mineral chromium activates the glucose transporter molecule within the cell called GLUT4. Chromium can improve blood sugar levels, insulin sensitivity, and lipid profiles.

Omega-3 Fatty Acids

Endometriosis is associated with inflammation, pelvic pain, and hormonal imbalances.  Omega-3 fatty acids help to reduce inflammation, relieve pain, and regulate hormone production. These important fatty acids also improve insulin sensitivity which is important for balancing blood sugar.

Omega-3 fatty acids are essential fats that are found in fatty fish such as wild-caught salmon and sardines, grass-fed meats, pasture-raised eggs, nuts (especially walnuts), and seeds (flax, hemp, and chia seeds). Flax, hemp and chia seeds have the added benefit of improving estrogen levels in the body.

An excellent source of Omega-3 fatty acids is ProOmega CRP. ProOmega CRP has 1260 mg of EPA and DHA, concentrated Omega-3 fish oils. It also contains Optimized Curcumin, L-Glutathione, and N-Acetylcysteine (NAC). This unique combination makes ProOmega CRP one of the most powerful supplements available for down-regulating inflammation and oxidative stress quickly.

Magnesium

Women with endometriosis often have low levels of magnesium due to estrogen dominance. Menstruation can further deplete their magnesium.

Magnesium is a crucial nutrient that supports over 300 physiological processes or functions in the body. It is called the “master mineral” and plays an important role in regulating hormone levels.

The top food sources of magnesium are leafy greens such as Swiss chard and spinach, sea vegetables, sprouts, and avocados. Grass-fed dairy and wild-caught fish are rich in magnesium. Pumpkin seeds, nuts, dark chocolate, and coffee are also good sources of magnesium.

Brain Calm Magnesium contains Albion forms of magnesium, malate, lysinate, and glycinate. It also contains magnesium L-threonate, the only form of magnesium proven to cross the blood-brain barrier. Boosting your magnesium level is important for hormonal balance and overall health.

Other great ways to get magnesium are Epsom salt baths and a topical cream or spray.

Magnesium Oil Ultra is a topical spray which passes directly into the tissues where it is transported to the cells throughout your body.

Vitamin D

Vitamin D is an important factor in the prevention and treatment of many chronic diseases. Low levels of vitamin D have been associated with endometriosis (7).

D3 is the biologically active form of vitamin D. It is more potent in raising and maintaining vitamin D concentrations than D2. Vitamin D3 is created in your skin in response to sun exposure. Aim to get 15-20 minutes of sun exposure daily.

The best dietary sources of vitamin D are wild-caught salmon and fatty fish, cod liver oil, grass-fed butter, and raw cheese, egg yolks, mushrooms, and beef liver.

The ideal range for vitamin D3 levels is between 50-80 ng/ml. It is important to keep vitamins D3 and K2 in balance which can be done by taking a Vitamin D3/K2 supplement such as D3/K2 Power.

Milk Thistle

Detoxifying your liver can naturally balance hormones. Milk thistle protects the liver from damage and enhances the detoxification process. It speeds up estrogen clearance from the body. Milk thistle also contains a flavonoid complex which is important for protecting cells against free radical damage and inflammation.

The liver is responsible for breaking down and eliminating excess hormones from the body. If the liver is not functioning properly, older hormones can recirculate into the bloodstream in an even more toxic form than when they originally entered the liver. These toxic forms of estrogen can dramatically increase the risk of endometriosis and other issues.

Kidney & Liver Detox is an excellent product for detoxifying the liver. It contains milk thistle, along with NAC, parsley gynostemma, Collinsonia root, beetroot, and marshmallow root. It is a bioactive carbon product that focuses on drainage and immune support throughout the kidneys and liver.

Milk Thistle Benefits2

Berberine 

Berberine is a plant alkaloid derived from a variety of herbs, including Oregon grape root. It modulates the immune system and has numerous anti-inflammatory effects. Berberine repairs intestinal permeability, stabilizes blood sugar, and neutralizes the bacterial toxin LPS (8). LPS is high in women with endometriosis.

Berberine has been shown to inhibit the growth of endometrial tissue (9). It is also a great liver detoxifying herb, making it helpful for reducing excess estrogens found with endometriosis.

A fantastic supplement with berberine is GI Regulator. GI Regulator contains a concentrated 4:1 extract of Oregon grape root, which supplies berberine. It also has bayberry bark and grapefruit seed extract to complement berberine’s ability to support healthy microbes, stimulate circulation, and promote mucous membrane health. Zinc is included in the formula for additional immune system support.

N-acetylcysteine (NAC)

NAC is the acetylated form of the amino acid cysteine which is naturally present in substances like garlic. Research shows that NAC is more effective than hormonal treatments at treating endometriosis. Unlike conventional treatments, NAC has no adverse side effects or associated toxicity (10).

ThyroLiver Protect is an excellent source of NAC. It also contains alpha lipoic acid, selenium, and milk thistle. Using ThyroLiver is an excellent way to supply your body with NAC and to support liver detoxification.

Essential Oils

Essential oils are a safe, effective way to improve endometriosis. Clary sage, geranium, cypress, frankincense, sandalwood, and helichrysum essential oils can be helpful for endometriosis. Clary sage helps to balance hormones and reduce symptoms of endometriosis. You can apply 2-4 drops topically over the abdomen and apply a warm compress to the area or add to your bath.

Cypress essential oil can improve circulation and geranium is a powerful anti-inflammatory. Frankincense and sandalwood are helpful for reducing inflammation and supporting healing. Helichrysum essential oil can help heal scar tissue and reduce inflammation and fluid retention.

You can also try massaging the pelvic muscles with lavender essential oil. This can relax the muscles and reduce inflammation.

Castor Oil Packs

Regularly applying castor oil packs to the lower abdomen may soften and eliminate endometrial tissues. Castor oil can penetrate deep into the abdomen and pelvis.

Castor oil is made up of phytochemicals including the fatty acid ricinoleic acid. Ricinoleic acid gives castor oil its unique healing properties and composes 90% of its chemical structure.

Using castor oil packs can support the body’s natural detoxification process by improving liver function, reducing inflammation, and strengthening the immune system.

Castor oil packs can also increase the flow of lymph, the fluid that circulates throughout the lymphatic system. This helps the lymphatic system remove debris and toxins in the body.

Castor oil packs are simple, yet effective and can be made at home with a few items. For details on how to make and use castor oil packs and when to avoid them, check out this article.

Endometriosis Castor Oil

Zinc

Women with endometriosis often have lower levels of zinc (11). Deficiencies of zinc are related to inflammation and lowered immunity, both of which contribute to endometriosis. Zinc also has antioxidant properties and protects our bodies against damaging free radicals.

There are numerous food sources of zinc including grass-fed beef and dairy, salmon, chicken, spinach, and asparagus. Nuts and seeds such as cashews, almonds, pumpkin seeds, and watermelon seeds are also high in zinc. It is best to soak or sprout nuts and seeds to reduce the level of phytic acids which can adversely affect zinc levels.

Supplementing with zinc can be helpful for people with zinc deficiencies.

Zinc Charge is a high-potency source of zinc formulated for enhanced absorption. Zinc Charge supports your immune system and proper enzymatic function.

Turmeric

Turmeric is a powerful herb with abundant health benefits. It has been used for centuries to treat a variety of conditions. Turmeric has antioxidant, anti-thrombotic, and antimicrobial properties. It is a potent anti-inflammatory which can improve symptoms of endometriosis.

Curcuminoids are bioactive compounds found in turmeric. Curcumin is the main curcuminoid. It inhibits the growth of endometriosis through several mechanisms.  Curcumin was found to suppress the growth of endometrial cells by reducing estradiol (E2) production (4). Estradiol is the major estrogen made in the ovaries.

Curcumin also downregulates vascular endothelial growth factor (VEGF), a protein produced by cells that stimulates the formation of blood vessels (12). This can decrease the growth of endometrial cells in endometriosis.

Meriva 500-SF is a liposomal form of curcumin with a higher absorbency rate than most other forms of curcumin. This formula is also soy-free which is important because soy has phytoestrogen qualities and can negatively impact hormones.

Conclusion

Endometriosis is a painful disease where the tissue that normally lines the uterus grows outside of the uterus. This tissue can be on ovaries, fallopian tubes, and other areas. It affects women in their reproductive years.

There are numerous symptoms of endometriosis. The most common symptom is pelvic pain. This pain can be severe, especially during your period. Other symptoms include pain with intercourse, pain with bowel movements or urination, irregular (and often heavy) periods, fatigue, and infertility. Gastrointestinal symptoms are common as well. This painful condition also increases a woman’s risk of developing ovarian cancer.

While an exact cause is unknown, inflammation, hormonal imbalances, blood sugar imbalances, bacteria, and environmental toxins are factors that have been shown to contribute to the development and progression of endometriosis. Conventional treatments are often ineffective and have negative side effects.

There are numerous natural strategies to prevent and improve this condition. One of the main strategies is to consume an anti-inflammatory diet. Balancing your blood sugar and correcting hormonal imbalances are important strategies.

N-acetylcysteine, berberine, milk thistle, and turmeric have proven to be effective remedies. Addressing nutrient deficiencies that are common with endometriosis is also important. Women with this condition are often deficient in omega-3 fatty acids, magnesium, vitamin D, and zinc. Applying castor oil packs and using essential oils may also relieve the symptoms.

Sources for this Article Include:

1. Endometriosis, Mayo Clinic. Link here
2. PCOS and Endometriosis – Could you have both? Insulite Health PCOS.Link here
3. Keita M, Bessette P, et al., Expression of interleukin-1 (IL-1) ligands system in most common endometriosis-associated ovarian cancer subtypes. 2010 Jan; 3:3. PMID: 20181040
4. Zhang Y, Cao H, et al., Curcumin inhibits endometriosis endometrial cells by reducing estradiol production, 2013 May; 11(5): 415-422. PMID: 24639774
5. Khan K, Fujishita A, et al., Bacterial contamination hypothesis: a new concept in endometriosis. 2018 Apr; 17(2): 125-133. PMID: 29692669
6. Marziali M, Venza M, et al., Gluten-free diet: a new strategy for management of painful endometriosis related symptoms? 2012 Dec: 67(6): 499-504. PMID: 23334113
7. Ciavattini A, Serri M, et al., Ovarian endometriosis and vitamin D serum levels. 2017 Feb; 33(2): 164-167. PMID: 27809683
8. Liu L, Jiang C, et al., Berberine inhibits the LPS-induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway, 2017 Dec; 14(6): 6125-6130. PMID: 29285168
9. Liu L, Ning L, et al., Berberine inhibits growth and inflammatory invasive phenotype of ectopic stromal cells: Imply the possible treatment of adenomyosis, Journal of Pharmacological Sciences, 2018 May, Vol 137, Issue 1, pg 5-11. Link here
10. Porpora M, Brunelli R, et al., A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine, 2013 May; 240702. PMID: 23737821
11. Messalli EM, Schettino MT, et al., The possible role of zinc in the etiopathogenesis of endometriosis. 2014; 41(5): 541-6. PMID: 25864256
12. Cao J, Wei YX, et al., Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor. 2017 Oct; 16(4): 5611-5617. PMID: 28849024

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Comments

  1. Ingestion of essential oils is not safe.

    It stresses the liver and kidneys and we have no idea the effect it has on the gut microbiome?

    No studies indicate this as an effective protocol.

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