Systemic Enzymes are a Powerful Immune Support

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Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Systemic Enzymes for Immune Support:

The human body uses systemic enzymes to carry out virtually every metabolic function.  While supplemental enzymes play an important role in optimizing digestion taking enzymes outside of meal times has a powerful effect on the body’s immune response.  Using a wide array of different enzymes can provide a full-body anti-inflammatory effect that benefits several different systems in the body.

Enzymes are biocatalysts that are used to carry out and speed up the process of chemical reactions in the body.  We have around 3000 unique enzymes in our bodies that are involved in over 7000 enzymatic reactions (1).  We also consume enzymes when we eat raw, sprouted and fermented fruits and vegetables.  Supplementing with an array of plant and proteolytic systemic enzymes has been shown to have powerful health benefits (2, 3).

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Anti-Inflammatory Activity:

When the body is injured or under chronic stress the immune system initiates a protein chain called Circulating Immune Complex (CIC) that causes pain, redness and swelling in a particular region.  This is a beneficial process and early on is a necessary part of healing.

However, inflammation is self-perpetuating and creates further insult and irritation to the region.  Unless there is modulation of the CIC response the inflammation can dominate and overwhelm the region of the body creating painful and degenerative conditions (4, 5)

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

The Problem with NSAID Usage:

Non-Steriodal Anti-Inflammatory Drugs (NSAID’s) work by blocking CIC activity in the body.  This affects all CIC’s including those used to maintain the lining of the stomach, intestine, liver and kidneys.  This is why long-term NSAID usage causes liver and kidney toxicity, stomach ulcers and leaky gut syndrome (6, 7, 8).

Every year 20,000 Americans die from the over counter use of these drugs and another 100,000 end up in the hospital with liver and kidney damage and intestinal bleeding from NSAID usage (9).

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Immune System Modulations:

Systemic enzymes work to modulate or coordinate the activity of CIC’s and have no major adverse reactions.  They work as a lock and key mechanism and have an affinity for proinflammatory cytokines such as Tumor Necrosis Factor (TNF) and C Reactive Protein (CRP) (10).

Systemic enzymes help to destroy foreign proteins which include viruses, bacteria, yeasts and other parasites.  They also help to destroy abnormal cells such as cancer cells (11).  They will also destroy excessive anti-bodies that the body is producing such as in cases of auto-immune diseases (12, 13, 14).

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Systemic Enzymes Have Anti-Fibrolytic Activity:

Fibrosis is scar tissue that the body produces in the repair process of cuts and wounds on the outer and inner surfaces of our body.  When we have optimal enzyme stores the enzymes are used to clean up fibrolytic tissue in the body.

However, when our enzyme stores are being depleted due to chronic stress and inflammatory activity the fibrolytic tissue builds up.  When the body has an abundance of fibrolytic tissue build up we end up with things like fibrocystic breast disease, uterine fibroids, endometrosis and arteriol sclerosis.

Systemic enzymes eat fibrolytic tissue and prevent the fibrosis of our organs and tissues (15).  They have a remarkable ability to not only prevent all of the above conditions but also to eat up old scar tissue.  This includes surgical wounds, pulmonary fibrosis, kidney fibrosis and even old keloid plaques.

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Blood Cleansing Activity:

Chronically inflamed individuals often times end up with very thick blood that is loaded with fibrin that can lead to heart attacks and strokes.  Doctors often prescribe asprin and in more extreme cases powerful pharmaceuticals like Coumadin, Heparin and Plavix.  These have very dangerous side effects.

Systemic enzymes are able to clear up excess thickening agents such as fibrin from the blood stream and naturally thin the blood (16).  They also break down dead material including dead blood cells, pathogens, toxic debris and immune agents that have been left in circulation.  This helps cleanse and detoxify the blood stream and enhances circulation and cellular oxygenation.

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

My Favorite Systemic Enzyme Supplement:

I recommend Proteo Enzymes which have pancreatic enzymes and the powerful biofilm buster serrapeptidase.  This supplement is awesome for reducing inflammatory activity in the body.  I use this for myself and athletes as it is powerful for exercise recovery and improving performance.

I also use this for clients who are in chronic pain, have swelling/edema in their legs or have an injury.  It is also fantastic for breaking down old scar tissue and improving range of motion in restricted joints.

This supplement is great for people with microbial overgrowth as the proteolytic enzymes help to metabolize the outer biofilms of the various microbes.  Often, people have trouble reducing microbial overgrowth because of these biofilms.  This supplement can be a huge game changer for someone trying to heal from digestive complaints.

This supplement is also great for reducing antibodies in individuals with various autoimmune conditions such as Hashimoto’s, Rheumatoid arthritis, Lupus and Scleroderma.  The systemic enzymes will help the body to break down anti-bodies and scar tissue from inflammatory damage.

I also use this with cancer patients to break down the thick outer protein layer on the outside of cancer cells.  This fibrytic outer layer protects the cancer cells from the immune system.  These enzymes are able to metabolize this outer layer and make the cancer cells more vulnerable to the body’s natural immune attack.

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

Sources for This Article Include:

1. Holliday GL, Fischer JD, Mitchell JBO, Thornton JM. Characterizing the complexity of enzymes on the basis of their mechanisms and structures with a bio-computational analysis. The Febs Journal. 2011;278(20):3835-3845.
2. Conrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014 Winter;20 Suppl 1:32-7. PMID: 24473984
3. Hale LP, Chichlowski M, Trinh CT, Greer PK. Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493
4. Jewell DP, MacLennan ICM. Circulating immune complexes in inflammatory bowel disease. Clinical and Experimental Immunology. 1973;14(2):219-226.
5. Fuggle NR, Howe FA, Allen RL, Sofat N. New insights into the impact of neuro-inflammation in rheumatoid arthritis. Frontiers in Neuroscience. 2014;8:357.
6. Bessone F. Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage? World Journal of Gastroenterology : WJG. 2010;16(45):5651-5661.
7. Ejaz P, Bhojani K, Joshi VR. NSAIDs and kidney. J Assoc Physicians India. 2004 Aug;52:632-40. PMID: 15847359
8. Satoh H, Takeuchi K. Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents. Curr Med Chem. 2012;19(1):82-9. PMID: 22300080
9. Bandolier – NSAIDs and adverse effects Link Here
10. Huang JR, Wu CC, Hou RC, Jeng KC. Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14. Immunol Invest. 2008;37(4):263-77. PMID: 18569070
11. Beuth J. Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction? Integr Cancer Ther. 2008 Dec;7(4):311-6. PMID: 19116226
12. Hale LP, Chichlowski M, Trinh CT, Greer PK. Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493
13. Lequette Y, Boels G, Clarisse M, Faille C. Using enzymes to remove biofilms of bacterial isolates sampled in the food-industry. Biofouling. 2010 May;26(4):421-31. Erratum in: Biofouling. 2010 Aug;26(6):753. PMID: 20198521
14. Fitzhugh DJ, Shan S, Dewhirst MW, Hale LP. Bromelain Treatment Decreases Neutrophil Migration to Sites of Inflammation. Clinical immunology (Orlando, Fla). 2008;128(1):66-74.
15. Kakinuma A, Moriya N, Kawahara K, Sugino H. Repression of fibrinolysis in scalded rats by administration of Serratia protease. Biochem Pharmacol. 1982 Sep 15;31(18):2861-6. PMID: 6753849
16. Heinicke RM, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia. 1972 Jul 15;28(7):844-5. PMID: 4658882
17. Clinical Trials – Multi-Center Study Evaluating the Efficacy of Wobenzym(R)N in Treating knee Osteoarthritis. Link Here
18. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evidence-based Complementary and Alternative Medicine. 2004;1(3):251-257.

Systemic Enzymes, Systemic Enzymes are a Powerful Immune Support

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  1. Great to know that there are better alternatives to NSAIDs! Could Proteo enzymes increase Glutamate in some way? I found that Protease could increase glutamate (not sure if it’s a reliable source). I hope it’s not the case

  2. Are these ok to take in pregnancy? (Especially if they are started before)…thanks for your website, very helpful!!

  3. Many thanks for another very interesting article.

    I realise that systemic (proteolytic) enzymes are to be consumed away from food and I notice that one of their benefits is to break up biofilms in the gut. This makes sense.

    However, I am unsure how an intact protein molecule (an enzyme) would go from the gut into the bloodstream intact, without the need for it to be broken down into smaller peptides. I thought undigested proteins going from the gut into the blood was a sign of a leaky gut.

    I like all the benefits you describe but I’d be most grateful for your thoughts on how intact proteolytic enzymes are transported from the gut to the blood.

    1. Yes proteolytic enzymes are very unique in that they aren’t metabolized by the body. However, if you take them with meals, they will act to break down the food you are consuming and will not get into circulation.

  4. I need to know if I can take either systemic or proteolytic enzymes while I am taking Plavix. I have been
    diagnosed with IPF recently and based on the research I’ve been doing, I believe that these enzymes would
    help me with my problem. However, if they would interfere with the blood thinner (plavix) that I am taking,
    then I could not take them.
    Thank you.

  5. How does the body get rid of the “gunk” that is being broken up by the enzymes? Can it cause other reactions in the body? Like more pain or other side effects, possibly leading to something good and no pain, but how do you know what is bad and what you just need to push through if there is a reaction to the break down?
    Thank you!!

    1. These are good questions, the body eliminates the waste through the lymphatic system which takes it to the liver, gut and kidneys. You want to make sure your drainage pathways are working well!

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