Most people think of mitochondria as simple energy factories and the gut microbiome as something tied only to digestion. In this episode, I sit down with Jason Prall to reveal why that view is outdated—and how these two systems are in constant communication, shaping everything from inflammation and immunity to aging and resilience.
Jason explains how mitochondria don’t just make energy; they send signals, respond to stress, and influence how cells adapt or break down over time. When that signaling goes wrong, the ripple effects can show up as fatigue, chronic inflammation, or long-term disease.
How Everyday Habits Shape Cellular Communication
What you eat matters—but when you eat, how you sleep, and how you move may matter even more. This conversation dives into how light exposure, fasting, exercise, and even mental stress act as signals that either strengthen or disrupt the microbiome–mitochondria relationship.
You’ll hear why short bursts of stress paired with real recovery can build more resilient mitochondria, and how modern lifestyles quietly keep the body stuck in a low-grade stress state that undermines healing.
Small Shifts That Can Change Long-Term Health
Rather than focusing on extreme protocols, this episode invites you to rethink simple daily habits that support better cellular communication. From sleep timing to movement and environmental inputs, the discussion opens the door to understanding how the body restores balance—and why true health starts at the cellular level.
If you’re interested in longevity, energy, and preventing chronic disease from the inside out, this episode will change how you think about your gut, your mitochondria, and the signals you send them every day.
- 00:00 Introduction to Human and Mitochondrial DNA
- 04:06 Deep Dive into Mitochondria and Aging
- 14:01 Understanding the Gut Microbiome
- 25:38 Environmental Factors Affecting Health
- 29:19 Mindfulness and Detoxification
- 29:55 Impact of Thoughts on Health
- 31:06 Personalized Health Approaches
- 31:39 Universal Health Strategies
- 33:43 Importance of Sleep
- 37:19 Exercise and Movement
- 41:07 Fasting and Meal Timing
- 45:48 Stress and Recovery Balance
- 48:42 Final Thoughts and Resources
Episode Sponsors
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Dr. Josh Axe
I just wanna take a moment to interrupt this podcast to tell you about one of my favorite podcasts I listen to. It’s called The Dr. Josh Axe Show, hosted by my good friend Dr. Josh Axe. Every week he shares how to balance your hormones, restore your gut, boost your energy, and slow aging without relying on harsh medications or quick fixes.
He shares both ancient biblical practices and the latest breakthroughs in nutrition, herbal remedies, and lifestyle medicine. If you’re ready to take control of your health, renew your energy, and transform your mind, body, and spirit, tune into The Dr. Josh Axe Show every Monday and Thursday wherever you get your podcasts.
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Resources:
- Paleovalley Bone Broth Protein: Save 15% on grass-fed bone broth protein at paleovalley.com/jockers.
Connect with Jason Prall:
- Book: https://amzn.to/3YC78Wt
- Website: humanlongevityfilm.com, beyondlongevitybook.com
Connect with Dr. Jockers:
- YouTube
- Website
- If you are interested in being a guest on the show, we would love to hear from you! Please contact us here!
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