Heart Disease: Major Causes and Natural Support Strategies

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heart disease, Heart Disease:  Major Causes and Natural Support Strategies

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Heart Disease: Major Causes and Natural Support Strategies

Chances are you have been taught that high cholesterol is the cause of heart disease.  This has been the modern vernacular since Ancel Keys came out with his “lipid hypothesis” theories in the 1950’s.  This hypothesis linked elevated dietary saturated fat and cholesterol to increased risk of heart disease.  In this article, you will discover the major causes of heart disease and natural support strategies to improve heart health.

21st century science is giving us a much greater understanding of cholesterol’s role in atherosclerosis and coronary heart disease.  This new understanding is that cholesterol is more of an innocent victim than a harmful contributer of this disease (1, 2, 3).

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Lipoproteins and Inflammation:

The lipid particles that transport cholesterol in circulation are called lipoproteins. Within this classification, you have low-density lipoproteins (LDL), high density lipoproteins (HDL) and very low-density lipoproteins (VLDL).  Contained within these lipoproteins are one or more proteins, called apolipoproteins, which act as molecular “signals” to facilitate the movement of lipid-filled lipoproteins throughout the body.

Cholesterol does not cause heart disease, however, oxidized cholesterol does cause major problems within the body.  When inflammatory pathways are elevated, cholesterol molecules are oxidized, triglycerides are formed & blood vessel walls damaged (4, 5).

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

The Truth About LDL:

LDL has always been called the ‘bad cholesterol” because it is associated with arterial plaque.  But it actually performs many key features including transporting important fat soluble nutrients such as vitamin A, vitamin E, vitamin D and coQ10 to the cells of the body.  Current science is demonstrating that the demonization of all LDL particles has been a big mistake.

LDL particles help to carry fat-soluble antioxidants, like CoQ10, vitamin E, and carotenoids, which protect the transported lipids from oxidative damage. This is why vitamin E and CoQ10 have performed so well in cardiovascular studies – because they prevent the oxidative modification of LDL particles, which in turn protects the blood vessel lining from damage.

Increasing evidence has revealed that the concentration and size of the LDL particles more powerfully relates to the degree of atherosclerosis progression than the concentration contained within all the LDL particles (6, 7, 8).

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Pattern A LipoProtein Profile:

Two main classifications of LDL particles exist.  These are individually called Pattern A and Pattern B lipoproteins.  Pattern A are classified as large and buoyant particles that contain more fat and anti-oxidants than their Pattern B counterparts.  Pattern B lipoproteins are small and dense and carry less anti-oxidant protection.

Large buoyant LDL particles carry a high volume of the antioxidant Vitamin E, which helps to fend off free radicals.  They pose only a very small chance of being oxidized while traveling through the circulatory system (9).

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Pattern A Lab Findings:

Low Density Lipoprotein (LDL):               Can be low-normal-high

High Density Lipoprotein (HDL):              Normal

Triglycerides (TG):    Normal

Regardless of where the LDL value is this is a very healthy blood lipid panel.  The TG/HDL ratio is the key.  If the TG/HDL ratio is greater than 2 than there is a strong likelihood that there is a large population of small dense LDL particles.  A TG/HDL ratio closer to 1 is what typically occurs with a smaller population of small dense LDL particles.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Pattern B LipoProtein Profile:

Pattern B lipoproteins are considered small, dense LDL particles.  These particles carry less fat-soluble antioxidants such as Vitamin E.  This increases the likelihood of oxidation by free radicals and the development of atherosclerotic plaque (10, 11).

One of the major problems with these small dense particles has to do with their relationship with the inner lining of the blood vessels called the endothelium.  Due to the small particle size, these pattern A LDL particles pose a major threat of slipping into the endothelial wall where they are trapped.  This then causes oxidation and significant endothelial damage.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Pattern B Lab Findings:

LDL:               Can be low-normal-high

HDL:               Low

Triglycerides:  High

Regardless of where the LDL value is this is a very dangerous blood lipid panel.   High TG and Low LDL is the common laboratory finding on a basic lipid panel.   You can map out all of your LDL and HDL variants with a Vertical Auto Profile or VAP test.

This test identifies twice as many people at risk than routine cholesterol tests, including those with inherited risk factors who often develop premature heart disease.

Like routine tests, the VAP Test measures total cholesterol, HDL (“good” cholesterol), LDL (“bad” cholesterol), and triglycerides. But the VAP Test also measures cholesterol subclasses that play important roles in the development of heart disease (12).

This additional information allows your doctor to improve the detection of heart disease risk from about 40% to 90% and provides a foundation for patient-specific treatment plans.  We offer the VAP test along with our entire cardiovascular biomarker analysis in the CardioPower test.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

What Causes Pattern B Findings:

From a nutritional perspective, there are several major causes:

1.  Too Many Fats that Kill:  Trans-fats common to processed foods and high omega 6 fats (vegetable oils and grain-fed meat) cause a rampant increase in prostaglandin E2 and inflammatory mediators that cause massive amounts of free radicals and tissue damage (13, 14).

2.  Not Enough Fats that Heal:  Saturated fats common to coconut oil & grass-fed animal products have been shown to increase HDL and enhance Pattern A lipoprotein function (15, 16).  Additionally, good fats such as EPA/DHA within fish/krill oil and Omega 9 fats common to olive oil, avocados, and almonds play a significant role in lipoprotein function.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

3.    Sugar, Grains & Corn Syrup:

Sugar:  Causes a very quick increase in blood sugar.  When blood sugar rises qucikly; the pancreas pumps out massive amounts of insulin very quickly.  High circulating insulin increases triglyceride and cholesterol formation, while additionally promoting inflammatory pathways (17, 18).

Grains:  Cause a slower release of sugar into the blood stream.  This causes a slower but more prolonged increase in insulin.  The longer insulin remains elevated in our bloodstream, the longer our bodies “fat production and storage” pathways will be at work.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

High Fructose Corn Syrup: (HFCS):

Immediately stimulates lipogenesis (fat generation) by turning into activated glycerol (G-3-P), which provides the backbone for Triglycerides:  1 Glycerol + 3 Free Fatty Acids.

Additionally, the fatty acids created during fructose metabolism accumulate as fat droplets in your liver and skeletal muscle tissues, causing insulin resistance and non-alcoholic fatty liver disease (NAFLD). Insulin resistance progresses to metabolic syndrome and type 2 diabetes (19, 20, 21).

The metabolism of fructose by your liver creates a long list of waste products, toxins, and free radicals.  These free radicals steal anti-oxidants from our system and damage tissues in a process called glycation.

Additionally, fructose metabolism creates large amount of uric acid, which inhibits endothelial nitric oxide synthase, inhibiting nitric oxide production and driving up blood pressure (22, 23).  High uric acid is also the cause of gout.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

12 Natural Support Strategies For Heart Health:

Here are the best action steps to get started with on your journey to improve your heart health.  Not all of these strategies are FDA approved to prevent, mitigate, treat or cure heart disease and should not be confused as such.  You should always consult with your physician before stopping or changing medications or taking on new health strategies.

Additionally, you should be working with a functional health practitioner to help guide you through these strategies.  This is not an exhaustive list and there are other natural therapeutic strategies that I and functional health practitioners will utilize to help individuals with heart disease.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

1)  Follow An Anti-Inflammatory Ketogenic Diet:  It is important to follow an anti-inflammatory diet where you take out grains and sugars, processed vegetable oils and processed meat.  Instead focus your meals on healthy fats such as olives, olive oil, avocados, grass-fed butter, pasture-raised eggs, coconut oil and nuts and seeds.  Include organic, pasture-raised animal products and lots of non-starchy vegetables and herbs.  Here is a helpful article to put this into action.

2)  Reduce Stress:  Find ways to reduce stressful activities and enjoy more peace and calm.  Learn to thrive under stress by reading this article here

3)  Improve Your Sleep:  Sleeping a high quality 8-9 hours each night is key to healing and improving blood flow.  Follow the steps in this article to improve your sleep.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

4)  Use a High Quality Bone Broth or Collagen Protein:  This will provide collagen protein to help keep the blood vessels strong and working effectively.  Without adequate collagen, the blood vessels become weak, scarred and are unable to function well.

5)  Include Magnesium & B Vitamin Rich Foods:  Magnesium and B vitamins help to relax blood vessel walls.  The best magnesium rich foods include dark green leafy veggies, grass-fed dairy, raw cacao and pumpkin seeds.  You can also do Epsom salt baths to boost your magnesium levels.

6) Supplement With Omega 3’s:  Omega 3 fatty acids and in particular the long chain variety EPA and DHA are critical for stabilizing blood sugar, lowering triglycerides and improving lipoprotein characteristics.  Consume grass-fed meat, grass-fed butter, wild-caught fish and spirulina to get it in your diet.

It is also advisable to supplement with 2-5 grams daily of EPA/DHA and here is a helpful article on omega 3’s to support your journey.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

7)  Focus on Deep Breathing:  Improving your posture, seeing a high quality chiropractor and optimizing your breathing patterns is highly recommended.  Follow these tips here to improve your breathing patterns.

8)  Ground Your Body:  In our society we are surrounded by toxic electromagnetic frequency’s (EMF’s).  By going outside daily and walking barefoot on grass, dirt or sand you absorb natural EMF’s from the ground that balance your electrical rhythms.  Follow the steps in this article here.

9)  Get Regular Exercise:    Getting your body moving on a daily basis is extremely helpful for your cardiovascular system.  I would recommend walking for at least 20-30 minutes everyday and also engaging in resistance training at least 2-3 days a week to improve your muscle mass.

10)  Optimize Your Vitamin D Levels:  Low vitamin D levels are strongly associated with cardiovascular disease.  It is important to regular sun exposure and supplement with a high quality vitamin D3 to get your Vitamin D blood levels between 50-80 ng/ml.

I recommend taking a Vitamin D3 with K2 as vitamin K2 is extremely important for reducing calcium build-up in the vascular system.  Here is the Vitamin D3/K2 product I use with my clients.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

11) Use Anti-Oxidant Rich Herbs:  Add turmeric, ginger, oregano, garlic, basil, thyme and rosemary to as many dishes as possible and drink organic herbal teas on a regular basis.

12) Improve Your Mitochondria:  The mitochondria are the energy powerhouses of every cell.  When someone has heart disease or an abundance of small-dense lipoproteins and triglycerides they have dysfunctional activity going on in the mitochondria.

Support your body with clinical doses of B vitamins, CoQ10, L-carnitine, N-acetyl cysteine and Lipoic acid.  The supplement I use with my cardiovascular patients is Mito Support which has the clinically effective dosages of each of these key nutrients and more.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

Sources For This Article Include:

1. Ravnskov U. The fallacies of the lipid hypothesis. Scand Cardiovasc J. 2008 Aug;42(4):236-9. PMID: 18615352
2. Rosch PJ. Cholesterol does not cause coronary heart disease in contrast to stress. Scand Cardiovasc J. 2008 Aug;42(4):244-9. PMID: 18609060
3. Ravnskov U. A hypothesis out-of-date. the diet-heart idea. J Clin Epidemiol. 2002 Nov;55(11):1057-63. PMID: 12507667
4. Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. J Psychosom Res. 2002 Jan;52(1):1-23. PMID: 11801260
5. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr. 2006 Feb;83(2):456S-460S. PMID: 16470012
6. Superko HR, Gadesam RR. Is it LDL particle size or number that correlates with risk for cardiovascular disease? Curr Atheroscler Rep. 2008 Oct;10(5):377-85. PMID: 18706278
7. Rizzo M, Berneis K. Low-density lipoprotein size and cardiovascular risk assessment. QJM. 2006 Jan;99(1):1-14. PMID: 16371404
8. Rizzo M, Berneis K, Corrado E, Novo S. The significance of low-density-lipoproteins size in vascular diseases. Int Angiol. 2006 Mar;25(1):4-9. PMID: 16520717
9. Diffenderfer MR, Schaefer EJ. The composition and metabolism of large and small LDL. Curr Opin Lipidol. 2014 Jun;25(3):221-6. PMID: 24811298
10. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, Després JP. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study. Circulation. 1997 Jan 7;95(1):69-75. PMID: 8994419
11. St-Pierre AC, Cantin B, Dagenais GR, Mauriège P, Bernard PM, Després JP, Lamarche B. Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):553-9. PMID: 15618542
12. Kulkarni KR, Garber DW, Marcovina SM, Segrest JP. Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J Lipid Res. 1994 Jan;35(1):159-68. PMID: 8138718
13. Trans Fatty Acids and Cardiovascular Disease Link Here
14. Harris WS, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel LL, Appel LJ, Engler MM, Engler MB, Sacks F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation. 2009 Feb 17;119(6):902-7. PMID: 19171857
15. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010 Mar;91(3):535-46. PMID: 20071648
16. Micha R, Mozaffarian D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence. Lipids. 2010 Oct;45(10):893-905. PMID: 20354806
17. Howard BV, Wylie-Rosett J. Sugar and cardiovascular disease: A statement for healthcare professionals from the Committee on Nutrition of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation. 2002 Jul 23;106(4):523-7. PMID: 12135957
18. Blood glucose and coronary heart disease Link Here
19. Stanhope KL, Bremer AA, Medici V, et al. Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women. The Journal of Clinical Endocrinology and Metabolism. 2011;96(10):E1596-E1605.
20. Angelopoulos TJ, Lowndes J, Zukley L, Melanson KJ, Nguyen V, Huffman A, Rippe JM. The effect of high-fructose corn syrup consumption on triglycerides and uric acid. J Nutr. 2009 Jun;139(6):1242S-1245S. PMID: 19403709
21. Tappy L, Lê KA, Tran C, Paquot N. Fructose and metabolic diseases: new findings, new questions. Nutrition. 2010 Nov-Dec;26(11-12):1044-9. PMID: 20471804
22. Oshida Y, Tachi Y, Morishita Y, Kitakoshi K, Fuku N, Han YQ, Ohsawa I, Sato Y. Nitric oxide decreases insulin resistance induced by high-fructose feeding. Horm Metab Res. 2000 Sep;32(9):339-42. PMID: 11014380
23. Johnson RJ, Perez-Pozo SE, Sautin YY, et al. Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocrine Reviews. 2009;30(1):96-116.

heart disease, Heart Disease:  Major Causes and Natural Support Strategies

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  1. This is Wagner and I’m from Brasil. I having dealing with some troubles with my levels of TG and LDL. Pretty good article. God bless you for provide us with so valuable information. Thank you a lot Doctor Jockers!

  2. Thanks for the article. Well presented for the lay person searching thru the endless so called solutions. Esselstyn and Campbell say no oil at all. Cardiologist claims butter is not bad. NIH PMC has a Study for any conclusion one may want. ACC’s claims do not mirror AHA. And then the ACC “protocol” for statins where they are rigid on dosage. One size does not fit all but they believe it does. Then again they have nothing to gain from WFPB diets and fewer, if any, trips to the cath lab or bypass, and no drugs. I particularly found interesting you comments on TG/HDL as it relates to small ldl particles. Is 1.17 considers “closer to 1”? What is the range to look for? Thanks again, your articles are saved and will be reread soon.

  3. About the Brain supercharge, I have a concern about Magnesium Stearate that is included in the ingredients. I have read that is not good.

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