Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

  • FDA Disclaimer
    The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. Learn More
  • Affliliate Disclosure
    In compliance with the FTC guidelines, please assume the following about links and posts on this site: Many of the links on DrJockers.com are affiliate links of which I receive a small commission from sales of certain items, but the price is the same for you. If I post an affiliate link to a product, it is something that I personally use, support and would recommend without an affiliate link. Learn More
  • Privacy Policy
    Please read the Privacy Policy carefully before you start to use DrJockers.com. By using DrJockers.com or by clicking to accept or agree to Terms of Use when this option is made available to you, you accept and agree to be bound and abide by the Privacy Policy. Learn More
Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural SolutionsLeaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Are you experiencing brain fog, fatigue, memory issues, trouble concentrating, headaches, dizziness, depression, or anxiety? You may have leaky brain. Leaky brain happens when the blood-brain barrier around your brain gets disrupted. This can lead to inflammation, nagging symptoms, and serious brain and mental health issues. The good news is that you can protect your brain through simple dietary and lifestyle changes.

In this article you will learn what leaky brain is. You will understand its main symptoms and long-term problems related to leaky brain. I will explain the main causes of leaky brain. I will share my top natural solutions for leaky brain to improve your health.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

What is Leaky Brain Syndrome 

If you’ve been following me for a while, you know that I have discussed leaky gut syndrome countless times. Due to unhealthy dietary and lifestyle choices, environmental toxicity, stress, and gut flora imbalance, your gut can become permeable or leaky. This means that food particles and toxins can pass through your gut lining, get into your bloodstream, stimulate your immune system, increase inflammation, and increase your risk of disease. It turns out that there is another condition associated with leaky gut, called leaky brain.

In leaky brain, a similar situation happens to leaky gut but in your brain. Your blood-brain barrier (BBB) is a protective layer that keeps your brain a sanctuary. It keeps bacteria, viruses, and other toxins away.

Similar issues, lifestyle choices, and toxicity that lead to leaky gut can lead to the interruption and destruction of the blood-brain barrier.  Here is a great image from GutGeek.com that explains the physiological details of the development of leaky brain.  

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Leaky Brain and Brain Degeneration

Leaky gut and leaky brain often occur at the same time. This is not surprising if you consider the connection between your gut and your brain. The proteins occludin and zonulin can both lead to gut and blood-brain barrier permeability. If you have antibodies against these two proteins, it may be a good indication that you have both leaky gut and leaky brain. Elevated microRNA-155 molecule levels also indicate increase inflammation that may result in microscopic gaps in the blood-brain barrier. Leaky brain increases your risk of brain inflammation, autoimmunity, and other health issues.

The breakdown of the blood-brain barrier has been seen in various brain degeneration. Leaky brain and brain inflammation may lead to brain fog, depression, anxiety, autoimmune brain disorders, and other mental health and brain health problems. If you are dealing with symptoms of any of these brain or mental health issues, you may have a leaky brain (1, 2, 3, 4, 5, 6).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Symptoms of Leaky Brain

Leaky brain may show up in a variety of ways. Symptoms of leaky brain include (7):

  • Brain fog
  • Dizziness
  • Irritability
  • Depression
  • Anxiety
  • Concentration troubles
  • Memory problems
  • Fatigue
  • Headaches or migraines

Long-Term Problems with Leaky Brain

Leaving leaky brain unaddressed can have serious consequences on your health. Having leaky brain for a long time may increase your risk of (7):

  • Cognitive decline or dementia
  • Neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease
  • Multiple sclerosis or peripheral neuropathy
  • Attention-deficit disorder (ADHD)
  • Autism spectrum disorder
  • Seizures
  • Mental health issues, including depression, anxiety, and schizophrenia

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Major Causes of Leaky Brain

There are a variety of health issues, dietary choices, and lifestyle factors that may increase your risk of leaky brain. Let’s look at some of the major causes of leaky brain.

Blood Sugar Imbalances 

If your diet is high in refined sugar and processed carbohydrates, but low in vegetables, brain-protecting healthy fats, and clean protein, you are setting your body up for blood sugar imbalances. While eating a quick high carb snack or carb-heavy meal may feel emotionally satisfying and give you a burst of energy short-term, it will also lead to a sudden blood sugar drop characterized by fatigue and brain fog.

Blood sugar imbalances, especially hypoglycemia can increase oxidative stress and inflammation and lead to leaky brain and compromise your brain health. It can result in brain fog, irritability, lightheadedness, mood fluctuations, anxiety, fatigue, and cravings (8, 9).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Chronic Inflammation

Chronic inflammation is the root cause of most modern-day disease and pain. Chronic inflammation caused by dietary habits, lifestyle choices, and the environment may increase your risk of leaky brain. Eating a high-calorie inflammatory diet and obesity may increase oxidative damage. It may also deprive your brain of oxygen.

Chronic inflammation also increases free-radical damage. The blood-brain barrier is highly sensitive to chronic inflammation and free-radical damage. Both of these factors can disrupt the blood-brain barrier and damage its protective tight junctions. This can lead to accelerated signs of aging, brain fog, memory troubles, and neurodegenerative diseases (7).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Dysbiosis and Intestinal Permeability 

As you’ve already learned, there is a clear and strong connection between your gut and brain health. It is easy to notice this connection during short-term events, such as a speaking engagement, new date, or any other important event when you may experience gut problems or at least butterflies in your stomach.

This connection between your gut and brain not only relevant during short-term exciting or stressful events. The communication between these two organs is ongoing, long-term, and intimate. Gut dysbiosis, gut infections, and intestinal permeability or leaky gut can increase your risk of leaky brain as well.

It leads to chronic inflammation and overall body imbalance. If you have gut dysbiosis, it means that you have too much yeast in your gut. It also means that you will have too much bad bacteria. Gram-negative bacteria are a certain bad bacteria that do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation, including E. Coli,  Salmonella, and Shigella.

The problem is that yeast releases acetaldehyde and gliotoxins and gram-negative bacteria release LPS endotoxins that disrupt the blood-brain barrier. Damage to the blood-brain barrier can lead to leaky brain and increase your risk and symptoms of brain fog, memory problems, cognition, mental health issues, mood imbalances, and neurodegenerative diseases (10, 11, 12, 13).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Chronic Stress & Poor Sleep

Chronic stress and poor sleep are two major factors that may lead to leaky brain. When your body is experiencing stress, your amygdala signals your hypothalamus which is response will increase your heart rate, heightens your senses, leads to heavier breathing and greater oxygen intake, increases cortisol levels, and rushes adrenaline across your system.

While cortisol is essential to deal with short-term stress, chronic stress leads to too much cortisol. Too much cortisol can wear your brain down, disrupt synapse regulation, impair brain function, and increase leaky brain. Chronic poor sleep increases chronic stress, chronically high cortisol, chronic inflammation, low mood, brain fog, and so on. This may lead to a vicious cycle and increase your risk of dementia, Alzheimer’s disease, and other neurodegenerative diseases (14, 15, 16, 17, 18)

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

High Toxic Load

Toxins are unfortunately all around us. They are in our polluted air, municipal tap water, non-organic and processed foods, moldy indoor spaces, plastic products, and conventional beauty, body, and household products. Environmental toxins and a high toxic load may have a serious impact on our brain and overall health.

Neurotoxins, such as ethanol (in alcohol), glutamate, nitric oxide, botulinum toxin (in Botox), tetrodotoxin, and tetanus toxin, are particularly damaging to your brain function. Environmental toxicity may lead to leaky brain, which increases your risk of memory problems, brain fog, dementia, neurodegenerative diseases, mood swings, irritability, fatigue, anxiety, depression, and mental health issues (19, 20, 21).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Vaccine Injury 

You may not be aware, but many vaccines contain aluminum adjuvant made of Al hydroxide and/or Al phosphate nanoparticles. It has been used in vaccines ever since the 1920s. While pharmaceutical companies claim that it is safe, it is far from the truth. Aluminum adjuvants dissolve very slowly in your body, which means that they can stay in your body for a long time. The problem is that aluminum particles can be very toxic.

Macrophage (MF) is type of immune cell that ingests aluminum adjuvant nanoparticles (AANs). When MF sees bacteria or other invadors in the body it destroys it with enzymes and eats it. The problem is that it doesn’t ingest AANs, which means that AANs can persist in them for a long time. If your MFs have too many AANs, they become highly contaminated with aluminum.

As the MFs cross the blood-brain barrier, they carry AAns inside them. They take AANs to your brain like a Trojan horse. Since your brain is highly sensitive to aluminum, this increases the risk of inflammation in the brain and brain health issues, including brain fog, memory troubles, cognitive decline, mental health issues, and autism spectrum disorder (22).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Systemic Infections & Chronic Mold 

Systemic infections and chronic mold exposure are some of the main causes of leaky gut. Lyme disease, the Epstein-Barr Virus, and other chronic systemic infections can increase inflammation, pain, and the risk of all kinds of health issues. These systemic infections can deteriorate the blood-brain barrier letting bacteria and other toxins enter the brain and damage it.

Mold toxins trigger inflammation in your body and may increase the risk of chronic inflammatory response syndrome (CIRS). This may lead to oxidative damage in the brain and damages the blood-brain barrier. Systemic infections and chronic mold may increase your risk of brain fog, memory issues, anxiety, fatigue, cognitive issues, and other brain problems (7).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Nutrient Deficiencies 

Eating an inflammatory diet, gut dysbiosis, poor nutrient absorption, stress, and poor lifestyle choices can set your body up for nutrient deficiencies. Nutrient deficiencies can increase your risk of inflammation and health issues, including leaky brain. Some of the main nutrient deficiencies that have been linked to leaky brain and brain health issues include vitamin D, magnesium, omega-3 fatty acids, and B vitamins.

A rat study has shown that vitamin D deficiency may increase blood-brain barrier dysfunction and consequently may lead to stroke. Magnesium deficiency may also reduce the blood-brain barrier permeability and increase the risk of stroke. Diets low in omega-3 fatty acids have been linked to cognitive deficits and cognitive decline, including Alzheimer’s disease. B vitamin, specifically B6 and B12 deficits have also been linked to blood-brain barrier dysfunction, whereas supplementation has shown promise in the treatment of mild cognitive issues (23, 24, 25, 26).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Natural Solutions to Leaky Brain

It’s clear that leaky brain is quite a serious problem that can lead to unwanted symptoms and serious health issues. The good news is that there are some natural solutions to leaky brain that help to improve your brain health and overall well-being. 

Reduce Stress & Increase Gratitude 

As you already know, chronic stress is incredibly damaging for your brain health and may increase your risk of leaky brain. Reducing your stress, therefore, is critical. Increasing gratitude in your life is one of the best ways to reduce stress.

Negativity cannot exist in a state of gratitude. Start your day by acknowledging the things that you are grateful for, and end your day with gratitude. Stop throughout the day to notice the small things. You may set reminders on your phone for one-minute gratitude practices. Keep a gratitude journal to write down three things you are grateful for. Because it is easy to stick to the easy one, such as friends, family, food on the table, or roof over your head, I challenge you to write down three new things each day.

If you are feeling down, you can always look back at your gratitude journal to see all the good things in your life. Additionally to a regular gratitude practice, I recommend that you practice meditation, breathwork, yoga, and grounding by walking barefoot on grass or dirt, take time to be in nature, spend time with loved ones, work on a positive mindset, pray or use other spiritual practices, and relax your body when you notice tension. If you need help with reducing stress, you may also seek professional help from a therapist, life coach, or spiritual counselor.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Improve Sleep Quality

Improving your sleep quality is important not only for leaky brain but your overall health. Sleep is essential for rest, cellular repair, and rejuvenation. Regular good sleep reduces stress, improves your energy levels, lowers inflammation, improves memory and cognition, improves your mood, and lowers the risk of disease.

Support your natural sleep-wake cycle by going to bed and waking up at the same time every day. Avoid eating, stressful activities, and electronics close to bedtime. Engage in relaxing activities, gratitude practice, meditation, and prayer to allow peace and quiet before going to sleep. Light a candle, use essential oils, or enjoy some herbal tea.

Create a peaceful sanctuary in your bedroom with a comfortable bed, bedding, and pillows. Having a salt lamp, calming crystals, your Bible or other spiritual books or tools around may be a good idea for create calm and peace. Use blackout curtains or eye masks to sleep in a dark room.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Anti-Inflammatory Nutrition Plan

You’ve probably heard the saying “You are what you eat.” While you are certainly much more than just the food you consume when it comes to your health, what you eat can set you up for success or failure. An inflammatory diet can lead leaky brain and health problems.

Eating an anti-inflammatory diet rich in nutrient-dense foods is one of the best things you can do for leaky brain and brain health. First, cut out all inflammatory foods, including refined sugar, gluten, refined oils, deep-fried and processed foods, conventional dairy, grain-fed meat and eggs, soda and sugary drinks, and foods that you are sensitive to.

Instead, focus on a anti-inflammatory nutrition plan and load up on greens, vegetables, low glycemic index fruits, herbs, spices, fermented foods, healthy fats, grass-fed meat, and wild-caught fish. To learn more about an anti-inflammatory diet, read this article as well (27, 28, 29, 30, 31, 32, 33, 34, 35, 36)

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Get Into Ketosis

Our modern-day diet is heavy or moderate in carbohydrates. As a result, most people’s body relies on glucose from dietary carbs to create energy. However, when your body doesn’t receive enough glucose because of a high-fat diet or fasting, it turns to dietary or stored body fat for energy.

These fats get turned into ketones that enter your mitochondria inside your cells and then get converted into energy. The benefits of ketosis include enhanced autophagy, reduced inflammation, improved mitochondrial biogenesis, improved brain health, and better mental sharpness.

The easiest and best way to achieve ketosis is through the combination of the ketogenic diet and intermittent fasting. To learn more about intermittent fasting, read the next section. To learn more about ketosis, I recommend reading this article. To learn more about the keto diet, I recommend this one (37, 38, 39, 40, 41, 42, 43, 44, 45, 46).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Practice Intermittent Fasting

Intermittent fasting is a form of fasting cycles between not eating (fasting) and eating (feasting) over a period of time. Intermittent fasting offers countless benefits including cellular repair, increased autophagy, immune regulation, inflammation levels, and insulin sensitivity.

It also helps to lower the risk of chronic diseases, including neurodegenerative conditions and mental health issues. If you are new to intermittent fasting, I recommend that you start with the Simple Fast, which includes only 12 hours of fasting including your overnight sleep. Slowly you can increase your fasting window.

Most people do the best with the 16:8 approach involving 16 hours of fasting. Make sure to consume nutrient-dense, anti-inflammatory foods during your eating window and meet your caloric needs. To learn more about the benefits of intermittent fasting and best intermittent fasting practices, I recommend this article (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Regular Movement & Exercise

Regular movement and exercise are critical to your brain health. It’s a non-negotiable natural strategy for leaky brain. Upon waking, make sure you move your body. Stretch out or do a quick morning yoga routine. You may step outside to do some grounding by walking barefoot on the grass.

Move throughout the day by getting up to stretch, strolling down the park during lunch, dancing for your favorite song, taking the stairs, walking your dog, and playing with your kids. Exercise for 20 to 30 minutes at least five times a week. Mix up cardio with strength and resistance training exercises.

High-intensity interval training (HIIT) is a great way to fit some cardio and strength training to your day within a short time. Other ideas for cardio include dancing, running, biking, swimming, and trampoline workouts. Other ideas for strength and resistance training include bodyweight workouts, weight lifting, and TRX. You may add lower impact workouts, including pilates, Barre, or yoga. End your day by stretching out.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Improve Gut Health

As you know, your gut and brain are closely connected. Improve your gut health by removing inflammatory foods and eating gut-friendly, anti-inflammatory, and nutrient-dense diet abundant in veggies, healthy fats, clean protein.

Eat plenty of prebiotic-rich foods, including onion, garlic, leek, asparagus, and Jerusalem artichokes, and probiotic-rich foods, such as sauerkraut, kimchi, and kefir. For additional support, I recommend taking a daily probiotic supplement.  You can also consider taking digestive enzymes, betaine HCL and ox bile to support digestion.  Finally, there are a number of good nutrients like L-glutamine, aloe, ginger, etc that help to reduce inflammation in the gut.  

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Reduce Toxin Exposure

Reducing your toxic exposure is critical for protecting your health from leaky brain. Buy organic food as much as possible. Stop using conventional beauty, body, and household products, and replace them with organic, natural, or homemade alternatives.

Use glass, stainless steel, wood, and bamboo products instead of plastic. Spend time in nature and breathe in the fresh air. Use a good indoor air filtration system. Make sure that you drink clean, toxin-free water by using a high-quality reverse osmosis system. 

I recommend systems like Aquatrue or the Berkey system for low cost filtration.  The best water is the Synergy Science hydrogen water which is what I use at home as it is powered by molecular hydrogen which reduces oxidative stress in the body and improves immune function.  Add a slice of lime for some extra flavor.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Support Detoxification Pathways

It is not enough to put good things into your body, you have to make sure that the bad things come out as well. Drink plenty of water to support detoxification through sweating and urine. Support your detoxification pathways to protect your body from leaky brain.

I recommend using infrared saunas to promote detoxification through sweating. Try rebounding and dry-skin brushing to support your lymphatic pathways.  Support two major detoxifying organs, your kidneys and liver with our Kidney and Liver Support which contains herbs like milk thistle, parsley, and beet root and is powered by bioactive carbons to get deep into the tissues and cells.  

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Use Targeted Supplementation

As you’ve learned, nutritional deficits are one of the major causes of leaky brain. Supplementation to correct nutritional deficiencies and reduce the risk of future deficits is critical. Additionally, supplementing with inflammatory and brain-supporting herbs is beneficial for leaky brain. Here is what I recommend:

Omega 3 Fatty Acids

Omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly beneficial for brain health and may help to prevent or improve brain degeneration. According to research, Omega-3 fatty acids may help to mitigate blood-brain barrier disruption. They may help brain injury, dementia, Alzheimer’s disease, depression, and anxiety, among other brain and mental health conditions.

While wild-caught fish is a great source of omega-3 fatty acids, I recommend supplementation, such as Pro Omega CRP for maximum support. This supplement helps to down-regulating inflammation and oxidative stress quickly, support a healthy gut, optimize cellular expression and cell signaling, and improve your brain health 58, 59, 60).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Vitamin D 

Vitamin D is a very important vitamin for brain function. Research has found that vitamin D supplementation may protect the blood-brain barrier, reduce neuroinflammation, and reduce the risk of neurodegenerative diseases and mental health issues.

To optimize your vitamin D levels, I recommend spending time out on the sunshine regularly. Make sure to eat plenty of vitamin D-rich foods, such as fatty fish, beef liver, and egg yolks. Since food and sunshine are not enough, I recommend daily supplementation with Vitamin D/K2 Liquid (23, 62).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Magnesium 

Magnesium is critical for brain health, mental health, stress relief, and relaxation. Research has shown its brain-protecting qualities and potential benefits for traumatic brain injury. Some good sources of magnesium include almonds, spinach, avocadoes, bananas, kale, pumpkin seeds, sunflower seeds, and cashews.

However, eating magnesium-rich foods is usually not enough to optimize your magnesium levels. To improve your magnesium levels protect your brain from leaky brain, I recommend Brain Calm Magnesium. This supplement helps muscle function, healthy nerve conduction, neurological function, energy production, mood, and mental health (63).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

B Vitamins 

B vitamins are important vitamins that are necessary for cellular health, energy levels, brain health, digestion, red blood cells, and nerve function. They are also important for avoiding leaky brain.

According to a study on the effects of high dose vitamin B12-B6-folate supplementation for 270 days, these B vitamins may be able to improve the blood-brain barrier and lower mild cognitive impairment. Foods high in B vitamins include meat, eggs, legumes, nuts, seeds, and dark leafy greens. Additionally, to eating a diet rich in B vitamins, I recommend taking B Strong and B12 Power (26).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Resveratrol 

Resveratrol is a powerful compound found in the skin of grapes and berries. Resveratrol offers immense health benefits through its powerful antioxidant, anti-inflammatory, and immune protecting properties. Not surprisingly, it is also great for leaky brain. Resveratrol may help to maintain a heathy blood-brain barrier.  Resveratrol also activates the NrF2 pathway which helps the cells detoxify and protect themselves from oxidative stress.

A rat study has shown that it may reduce cerebral ischemia-reperfusion damage, brain edema, and Evans blue dye extravasation therefore may show promise in helping brain health issues. To experience the benefits of resveratrol, I recommend Resveratrol Power (64, 65).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Curcumin 

Curcumin is the active compound of the spice, turmeric. Turmeric has been used for thousands of years in India and other Asian cultures for its medicinal healing properties. Curcumin is also one of the most well-researched spices with anti-inflammatory, antioxidant, and pain-reducing benefits. It turns out that it may also be great for leaky brain.

According to a study on changes of tight junction (TJ) proteins induced by oxygen-glucose deprivation (OGD) in the blood-brain barrier, curcumin may be able to benefits and improve the blood-brain barrier. To experience the benefits of curcumin, I recommend that you add turmeric to your smoothies, tea, soups, stews, and other dishes, and take turmeric supplements daily (66, 67, 68, 69, 70, 71).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Quercetin 

Quercetin is a flavonoid that can be found in vegetables and fruits, including leafy greens, broccoli, tomatoes, and berries. It is rich in antioxidants with anti-inflammatory and immune-supporting benefits. It may offer benefits for leaky brain.

Research has shown that quercetin is able to permeate through the blood-brain barrier and protect the brain and the barrier itself. To experience the benefits of quercetin along with resveratrol, I recommend Resveratrol Power (72, 73).

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Inflam Defense and Resveratrol Power for Extra Strong Support

For extra strong support, I recommend taking Inflam Defense™ and Resveratrol Power to lower inflammation and to protect your brain. Inflam Defense™ is a powerful combination of anti-inflammatory herbs, such as curcumin, boswellia, ginger, and rosemary extract as well as nutrients from quercetin and rutin, and proteolytic enzymes.

It is created to help downregulate the inflammatory process and deal with the negative impact of acute or chronic inflammatory conditions. Resveratrol Power combines resveratrol and quercetin to provide a synergy of nutrients to defend against oxidative damage, lower inflammation and support overall immune health.

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Final Thoughts

Leaky brain often occurs along with leaky gut syndrome. It happens when the blood-brain barrier around your brain gets disrupted.

This can lead to inflammation, brain fog, memory trouble, concentration issues, cognitive problems, anxiety, depression, and serious brain and mental health issues. Follow my natural strategies for leaky brain to improve your health and well-being and create the health and life you deserve.

Sources in This Article Include:

1. Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol. 2010;120(3):277‐286. Link Here
2. Block ML, Hong JS. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol. 2005;76(2):77‐98. Link here
3. Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol. 2002;38(6):323‐337. Link here
4. Obrenovich MEM. Leaky Gut, Leaky Brain? Microorganisms. 2018 Oct 18;6(4):107. doi: 10.3390/microorganisms6040107. PMID: 30340384
5. Morris G, Fernandes BS, Puri BK, Walker AJ, Carvalho AF, Berk M. Leaky brain in neurological and psychiatric disorders: Drivers and consequences. Aust N Z J Psychiatry. 2018;52(10):924‐948. Link Here
6. Lopez-Ramirez MA. MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation. Research Communications. 2014. Link Here
7. What causes leaky brain. Mindd Foundation. Link Here
8. How diabetes affects your brain. Web MD. Link Here
9. Blood sugar on the brain. Harvard Health Publishing. Link Here
10. Lucas G. Gut thinking: the gut microbiome and mental health beyond the head. Microb Ecol Health Dis. 2018 Nov 30;29(2):1548250. doi: 10.1080/16512235.2018.1548250. PMID: 30532687
11. Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr Med (Encinitas). 2018 Aug;17(4):28-32. PMID: 31043907
12. Rogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry. 2016 Jun;21(6):738-48. doi: 10.1038/mp.2016.50. Epub 2016 Apr 19. PMID: 27090305
13. Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota’s effect on mental health: The gut-brain axis. Clin Pract. 2017 Sep 15;7(4):987. doi: 10.4081/cp.2017.987. PMID: 29071061
14. Van der Kooij MA, Fantin M, Rejmak E, Grosse J, Zanoletti O, Fournier C,Ganguly K,Kalita K, Kaczmarek L, Sandi C. Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations. Nature Communications, 2014; 5: 4995. Link Here
15. Stress kills brain cells. Scientific American. Link Here
16. How stress and depression can shrink the brain. Yale University. ScienceDaily. ScienceDaily, 12 August 2012. Link Here
16. Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science, 2019.
17. The sleep deprived brain. Dana Foundation. Link Here
18. Zhao Z, Zhao X, Veasey SC. Neural Consequences of Chronic Short Sleep: Reversible or Lasting? Front Neurol. 2017 May 31;8:235. doi: 10.3389/fneur.2017.00235. PMID: 28620347
19. Yegambaram M, Manivannan B, Beach TG, Halden RU. Role of environmental contaminants in the etiology of Alzheimer’s disease: a review. Curr Alzheimer Res. 2015;12(2):116-46. doi: 10.2174/1567205012666150204121719. PMID: 25654508
20. Taking it all in: Environmental toxins and your health. Link Here
21. Liu J, Lewis G. Environmental toxicity and poor cognitive outcomes in children and adults. J Environ Health. 2014 Jan-Feb;76(6):130-8. PMID: 24645424
22. Vaccine Aluminum Travels Into The Brain. Vaccine Papers. Link Here
23. Sayeed I, Turan N, Stein DG, Wali B. Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats. Exp Neurol. 2019;312:63‐71. Link Here
24. Zhu D, Su Y, Fu B, Xu H. Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis. Mol Neurobiol. 2018;55(9):7118‐7131. Link Here
25. Pan Y, Choy KHC, Marriott PJ, et al. Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to 26. cognitive deficits from low omega-3 fatty acid diets. Link Here
26. Lehmann M, Regland B, Blennow K, Gottfries CG. Vitamin B12-B6-folate treatment improves blood-brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment. Dement Geriatr Cogn Disord. 2003;16(3):145‐150. 
27. Jeena K, Liju VB, Kuttan R. Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger.  Indian J Physiol Pharmacol. 2013 Jan-Mar; 57(1):51-62.  PMID:24020099
28. Panzhinskiy E, Hua Y, Lapchak PA, Topchiy E, Lehmann TE, Ren J, Nair S. Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J Pharmacol Exp Ther. 2014 May;349(2):248-57. PMID: 24549372
29. PubMed Health: Hyperglycemia Link Here
30. American Diabetes Association: Statistics About Diabetes Link Here
31. Schofield P. Dementia associated with toxic causes and autoimmune disease. Int Physchogeriatr. 2005; 17 Suppl 1: S129-47. PMID: 16240488
32. Jamall IS, Davis B. Chemicals and environmentally caused diseases in developing countries. Infect Dis Clin North Am. 1991 Jun; 5(2): 365-75. PMID: 1869814
33. Dietert RR, Dietert JM, Dewitt JC. Environmental risk factors for autism.Emerging Health Threats Journal. 2011; 4:10. PMCID: 3168222
34. Lee D, Hwang W, Artan M, Jeong D-E, Lee S-J. Effects of nutritional components on aging.Aging Cell. 2015; 14(1):8-16. PMCID: 4326908
35. Vela G, Stark P, Socha M, Sauer AK, Hagmeyer S, Grabrucker AM. Zinc in Gut-Brain Interaction in Autism and Neurological Disorders.Neural Plasticity. 2015; 2015:972791. PMCID: 4386645
36. Schwalfenberg GK. The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?Journal of Environmental and Public Health. 2012; 2012:727630. PMCID: 3195546
37. Vasconcelos AR, Yshii LM, Viel TA, et al. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. Journal of Neuroinflammation. 2-14;11:85
38. Aksungar FB, Topkaya AE, Akyildiz M. Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. Ann Nutr Metab. PMID: 17374948
39. Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio,Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda. Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice. Food and Nutrition Sciences2011, 2, 287-293 Published Online June 2011 Copyright © 2011 SciRes. Link Here
40. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010;6(6):702-710.
41. Anderson JL, Carlquist JF, Roberts WL, Horne BD, May HT, Schwarz EL, Pasquali M, Nielson R, Kushnir MM, Rockwood AL, Bair TL, Muhlestein JB; Intermountain Heart Collaborative Study Group.. Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk? Am Heart J. 2007 Jan;153(1):67-73. PMID: 17174641
42. Lanzi R, Luzi L, Caumo A, Andreotti AC, Manzoni MF, Malighetti ME, Sereni LP, Pontiroli AE. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism. 1999 Sep;48(9):1152-6. PubMed PMID: 10484056
43. Ji S, Guan R, Frank SJ, Messina JL. Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. J Biol Chem. 1999 May 7;274(19):13434-42. PMID: 10224108
44. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. 2007 Jul;86(1):7-13. PMID: 17616757
45. Buschemeyer WC 3rd, Klink JC, Mavropoulos JC, Poulton SH, Demark-Wahnefried W, Hursting SD, Cohen P, Hwang D, Johnson TL, Freedland SJ. Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. Prostate. 2010 Jul 1;70(10):1037-43. PMID: 20166128
46. Rogozina OP, Nkhata KJ, Nagle EJ, Grande JP, Cleary MP. The Protective Effect of Intermittent Calorie Restriction on Mammary Tumorigenesis is Not Compromised by Consumption of a High Fat Diet During Refeeding. Breast cancer research and treatment. 2013;138(2):395-406.
47. Faris MA, Kacimi S, Al-Kurd RA, Fararjeh MA, Bustanji YK, Mohammad MK, Sale ML. Intermittent fasting during Ramadan attenuates proinflammatory cytokines and immune cells in healthy subjects. Nutr Res. 2012 Dec;32(12):947-55. PMID: 23244540
48. Vasconcelos AR, Yshii LM, Viel TA, et al. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment. Journal of Neuroinflammation. 2-14;11:85
49. Aksungar FB, Topkaya AE, Akyildiz M. Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. Ann Nutr Metab. PMID: 17374948
50. Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio,Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda. Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice. Food and Nutrition Sciences2011, 2, 287-293 Published Online June 2011 Copyright © 2011 SciRes. Link Here
51. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010;6(6):702-710.
52. Anderson JL, Carlquist JF, Roberts WL, Horne BD, May HT, Schwarz EL, Pasquali M, Nielson R, Kushnir MM, Rockwood AL, Bair TL, Muhlestein JB; Intermountain Heart Collaborative Study Group.. Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk? Am Heart J. 2007 Jan;153(1):67-73. PMID: 17174641
53. Lanzi R, Luzi L, Caumo A, Andreotti AC, Manzoni MF, Malighetti ME, Sereni LP, Pontiroli AE. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism. 1999 Sep;48(9):1152-6. PubMed PMID: 10484056
54. Ji S, Guan R, Frank SJ, Messina JL. Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. J Biol Chem. 1999 May 7;274(19):13434-42. PMID: 10224108
55. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. 2007 Jul;86(1):7-13. PMID: 17616757
56. Buschemeyer WC 3rd, Klink JC, Mavropoulos JC, Poulton SH, Demark-Wahnefried W, Hursting SD, Cohen P, Hwang D, Johnson TL, Freedland SJ. Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. Prostate. 2010 Jul 1;70(10):1037-43. PMID: 20166128
57. Rogozina OP, Nkhata KJ, Nagle EJ, Grande JP, Cleary MP. The Protective Effect of Intermittent Calorie Restriction on Mammary Tumorigenesis is Not Compromised by Consumption of a High Fat Diet During Refeeding. Breast cancer research and treatment. 2013;138(2):395-406. Link Here
58. Zhang W, Zhang H, Mu H, Zhu W, Jiang X, Hu X, Shi Y, Leak RK, Dong Q, Chen J, Gao Y. Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury. Neurobiol Dis. 2016 Jul;91:37-46. doi: 10.1016/j.nbd.2016.02.020. Epub 2016 Feb 24. PMID: 26921472
59. Canhada S. Omega-3 fatty acids’ supplementation in Alzheimer’s disease: A systematic review. Nutr Neurosci. 2018 Oct;21(8):529-538. PMID: 28466678 
60. Grosso G, Galvano F, Marventano S, Malaguarnera M, Bucolo C, Drago F, Caraci F. Omega-3 fatty acids and depression: scientific evidence and biological mechanisms. Oxid Med Cell Longev. 2014;2014:313570. doi: 10.1155/2014/313570. Epub 2014 Mar 18. PMID: 24757497
61. Cardoso de Oliviera LR. Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation. Front. Pharmacol., 12 March 2020. Link Here
62. Anjum I, Jaffery SS, Fayyaz M, Samoo Z, Anjum S. The Role of Vitamin D in Brain Health: A Mini Literature Review. Cureus. 2018 Jul 10;10(7):e2960. doi: 10.7759/cureus.2960. PMID: 30214848
63. Magnesium. Nutrition and Taumatic Brain Injury. Link Here
64. Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, Fokou PVT, Martins N, Sharifi-Rad J. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018 Sep 9;6(3):91. doi: 10.3390/biomedicines6030091. PMID: 30205595
65. Wei H, Wang S, Zhen L, et al. Resveratrol attenuates the blood-brain barrier dysfunction by regulation of the MMP-9/TIMP-1 balance after cerebral ischemia reperfusion in rats. J Mol Neurosci. 2015;55(4):872‐879. Link Here
66. Prassad, S, Aggarwal, BB. Turmeric, the golder spice. Herbal Medicine: Biomolecular and Clinical Aspects. PMID: 22593922
67. Turmeric properties. US National Library of Medicine National Institutes of Health
68. Kuptniratsaikul, V, Thanakhumtorn, S, Chinswangwatanakul, P, Wattanamongkonsil, L, Thamlikitkul, V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. PMID: 19678780
69. Hanai, H, Iida, T, Takeuchi, K, Watanabe, F, Maruyama, Y, Andoh, A, Tsujikawa, T, Fujiyama, Y, Mitsuyama, K, Sata, M, Yamada, M, Iwaoka, Y, Kanke, K, Hiraishi, H, Hirayama, K, Arai, H, Yoshii, S, Uchijima, M, Nagata, T, Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. PMID: 17101300
70. Khajehdehi, P, Pakfetrat, M, Javidnia, K, Azad, F, Malekmakan, L, Nasab, MH, Dehghanzadeh, G. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol. PMID: 21627399
71. Wang YF, Gu YT, Qin GH, Zhong L, Meng YN. Curcumin ameliorates the permeability of the blood-brain barrier during hypoxia by upregulating heme oxygenase-1 expression in brain microvascular endothelial cells. J Mol Neurosci. 2013;51(2):344‐351. Link Here
72. Li, Y, Yao, J, Han, C, Yang, J, Chaudhry, MT, Wang, S, Liu, H, Yin, Y. Quercetin, inflammation and immunity. Nutrients. PMID:26999194
73. Li, Y, Yao, J, Han, C, Yang, J, Chaudhry, MT, Wang, S, Liu, H, Yin, Y. Quercetin, inflammation and immunity. Nutrients. PMID:26999194
Ren SC, Suo QF, Du WT, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41(5):751‐759. Link Here
74. Ren SC, Suo QF, Du WT, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41(5):751‐759. Link Here

Leaky Brain, Leaky Brain Syndrome: Symptoms, Causes and Natural Solutions

Was this article helpful?
YesNo

Let's Improve Your Health Today!

Get instant access to 2 FREE eBooks when you subscribe to Dr. Jockers’ newsletter.

ebooks

"Join my tribe today to discover hidden strategies to improve your energy, brain, digestion & metabolism."

— Dr. David Jockers
Dr Jockers

Comments

comments

Comments

  1. You should have been my science teacher when I was in school. This article is well written. Deserves to be in the curriculum.

  2. Is there a way to be able to print out these wonderfully informative articles? I have purchased seberal programs from your site and I am currently working with nutritionist Danielle. I have a notebook of a couple of articles I attempted to cute and paste but wasnt very successful. I am currently trying to work with the Brain program as i am having. Some cognitive concerns. It is a hard transformation but I will get there. Having youe resources is very helpful, especially, audio programs.
    Thank you.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.