Brain Autophagy: Healing the Toxic Brain

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brain autophagy, Brain Autophagy: Healing the Toxic Brain

brain autophagy, Brain Autophagy: Healing the Toxic BrainBrain Autophagy: Healing the Toxic Brain

Your brain is an incredibly important organ. It is the center of everything. It is responsible for learning, cognition, memory, thinking, and individual growth. Keeping your brain healthy is clearly critical. Brain autophagy is a process that allows your brain to regenerate, get rid of old and unhealthy cells, and replace them with new and healthier ones.

The problem is that as you age, there is an increasing risk of brain degeneration. Leading an unhealthy lifestyle and toxic environmental factors can lead to a decline in brain health and function. The good news is that making some lifestyle changes using natural brain-supporting strategies can help to enhance brain autophagy, support your brain function, and prevent brain degeneration.

In this article, you will learn about the importance of brain health, the process of brain degeneration, the importance of brain autophagy, and the importance of creating resilient brain mitochondria. I will share my top strategies to promote brain autophagy and brain health.

brain autophagy, Brain Autophagy: Healing the Toxic Brain

The Importance of Brain Health

If you think about it, your brain is one of your most important organs. Of course, it helps you think, but it’s much more than that. Your brain is the center of all of your body’s functions and systems. It is essentially the command center for your nervous system that perceives stimuli, activates responses, and obtains and sends signals across your body to keep you safe and healthy.

Your brain is where your memory is stored and learning, cognition, and individual growth is happening. It helps you stay clear and active. It allows work, play, and rest. Having a healthy brain is important for you to live a healthy and long life.

brain autophagy, Brain Autophagy: Healing the Toxic Brain

How The Brain Degenerates

Brain degeneration is a serious health problem that our aging society is facing in our world. Neurodegenerative or brain degenerative diseases, including dementia, Alzheimer’s disease, and Parkinson’s disease lead to brain and nerve deterioration over time. Alzheimer’s disease alone affects 5 million people in the United States.

Symptoms may include memory loss, confusion, forgetfulness, personality changes, mood changes, anxiety, apathy, agitation, or loss of inhibition depending on the type of brain degeneration you are experiencing. New symptoms can develop and symptoms tend to worsen as the disease progresses. While there is no cure for neurodegenerative disease, early diagnosis and treatment may be highly beneficial and dietary and lifestyle strategies may help to prevent or brain degeneration (1, 2, 3, 4, 5).

Most of your brain cells were formed while you were in your mother’s womb, others developed during infancy. While your brain cells are one of the longest living cells in your body, they may also die due to migration or differentiation, or simply get damaged and take abnormal turns. 

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Brain Degeneration

Your brain cells require the continuous supply of energy from your blood and their support cells, the glia for nutrients, survival, and toxin removal. Your nerve cells require a lot of energy – about 20 percent of your body’s oxygen requirement and 25 percent of its glucose requirement.

This energy supply is essential, as your brain cells can die only within a minutes after a blood supply failure. Your brain cells also need energy for all their cellular functions, including the trafficking of cell organelles, repairing cellular parts and membranes. These processes rely on certain proteins that can wear out over time and need to be broken down and removed. Some new replacement proteins may also be defective and need to be replaced as well.

Essentially, your nerve cells require constant resources and energy for survival, as well as regular clean up and maintenance to avoid potential protein build up. As you age, this may become increasingly difficult for your brain. Abnormal protein junk pile in nerve cells is commonly seen in the aging brain, especially in neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease.

While we don’t fully understand why these sticky protein clumps develop in the brain as we age it seems that dietary and lifestyle factors certainly play a role. Certain lifestyle and environmental factors, including blood sugar imbalances, environmental toxicity, sedentary lifestyle, poor sleep, chronic stress, and gut dysbiosis, may increase your risk of brain degeneration (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Neurogenesis and Brain Autophagy

The good news is that while old research believed that your brain has limited capacity to regenerate, new research suggests that your brain is actually able to create new cells throughout your lifespan and brain regeneration is possible. Your brain creates about 700 new neurons per day in the hippocampus allowing it to maintain its central function.

The science of neurogenesis suggests that certain lifestyle habits can encourage brain regeneration, improve your brain health, and may help to prevent or treat degenerative diseases. Brain autophagy is very important for preventing and slowing brain degeneration and allowing brain regeneration (24, 25, 26, 27, 28).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

What Is Brain Autophagy

The word autophagy comes from the Greek word ‘auto-phegein’ or ‘self-eating’. It refers to the process of cellular recycling where the cell itself metabolizes various components in order to reuse them and build new and healthier cell structures. 

Your cells contain a number of important components called organelles. When your cells are exposed to stressors, such as nutrient deprivation, they create a double-membrane structure called phagophore. The phagophore is very flexible and able to surround cellular components and deliver them to lysosomes. Lysosomes are unique organelles that are able to degrade particular components by releasing degrading enzymes upon them. 

The major driver of any autophagy is cellular stress. Your body is seeking balance and homeostasis. When stress, such as nutrient deprivation from fasting or exercise happens, your body needs to prepare for survival. To do this, it breaks down older or damaged cells and cellular organelles to leave room for the creation of new and healthier ones for better energy efficiency.

Brain autophagy refers to the process of autophagy in your brain. It allows the removal of old and damaged brain cells and the creation of new and healthy brain cells. Brain autophagy is essential for memory, cognition, and brain health, and may help to reduce brain degeneration. To learn more about autophagy, I recommend this article (29, 30, 31, 32).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Creating Resilient Brain Mitochondria 

Did you know that there are 10,000 mitochondria per brain cell? That’s a lot of mitochondria to take care of and keep healthy. They are the powerhouse of your brain cells, so their healthy functioning is critical. Mitochondrial dysfunction increases the risk of brain degeneration and brain health problems, so it is incredibly important to keep your brain mitochondria well-functioning.

Mitochondrial biogenesis is when cells increase their individual mitochondrial mass. Mitochondrial biogenesis through diet and lifestyle strategies, such as fasting, exercise, antioxidants, and certain supplements, can help to create resilient brain mitochondria and reduce brain degeneration and neurodegenerative disease (33).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Top Strategies to Promote Brain Autophagy

Brain autophagy is critical for promoting brain health and preventing brain degeneration. There are a number of different strategies you can apply to support your body’s ability to heal and repair brain cells. 

I would recommend putting into practice at least 6-8 of these strategies on a daily basis if possible.  The more of these you can stack together the faster you will enhance your brain autophagy.  

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Prioritize Restorative Sleep

To promote brain autophagy, it is important that you prioritize restorative sleep. Sleep is essential for rest, repair, and cellular regeneration. This means that sleep allows brain autophagy. I recommend that you go to sleep and wake up around the same time every day to support your circadian rhythm and sleep cycle. Avoid food, especially sugar and caffeine, close to bedtime. Choose herbal tea or a glass of water instead.

Turn off your electronics a few hours before bed. Wind down, instead, by reading, playing crossword puzzles, journaling, taking a bath, meditation, and prayer. Make sure that your bedroom is a safe and relaxing environment with a comfortable bed, bedding, pillows, and black-out curtains. Having a salt lamp or diffusing some lavender essential oils may also have some calming benefits (35).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Keep Stress Under Control

I know that the world can seem stressful, but keeping your stress under control is absolutely essential for brain autophagy and brain health. I recommend that you keep a gratitude journal and stop throughout the day to say thanks for the small things. Learn to reframe your negative thoughts into positive ones.

Working with a therapist or life coach or even your minister can help you develop skills to cope with stress better and create positive thinking patterns. Practice journaling, meditation, prayer, and breathing exercises to relax your mind and body. Go on nature walks, dance to your favorite song, try some arts and crafts, watch a funny movie, read an uplifting book, and spend time with uplifting people. Yes, phone and video calls count too, if you are currently far from your favorite people (36, 37)

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Get Into Ketosis 

Ketosis is a simple and effective way to support brain autophagy. Most people consume a diet that’s high or moderate in carbohydrates, which means that their body relies on glucose (sugar) for energy. However, if your body doesn’t receive enough glucose through diet due to fasting or eating a high-fat ketogenic diet, it has to turn to stored and dietary fat for energy. These fast convert into ketones that enter your mitochondria and convert into energy.

Ketosis supports enhanced autophagy, mitochondrial biogenesis, brain health, and mental sharpness. To achieve ketosis and support brain autophagy, I recommend a combination of the keto diet and intermittent fasting. To learn more about ketosis, I recommend reading this article, and to learn more about the keto diet, I recommend this one (38, 39, 40, 41, 42, 43, 44, 45, 46, 47).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Intermittent Fasting

Intermittent fasting is a fantastic way to improve brain autophagy. It is a form of fasting that rotates between not eating (fasting) and eating (feasting) over a period of time. Intermittent fasting has many benefits, including cellular repair, autophagy, immune regulation, inflammation levels, and insulin sensitivity.

It also helps to lower the risk of neurodegenerative conditions, such as dementia and Alzheimer’s disease. To learn more about the benefits of intermittent fasting and best intermittent fasting practices, I recommend reading this article (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Extended Fasting

Extended fasting is another way to improve brain autophagy. Extended fasting goes a step beyond intermittent fasting. While intermittent fasting only goes for anywhere between 12 to 23 hours of fasting a day, extended fasting least for at least a day, usually several hours, and in some cases even longer.

Extended fasting normally involves no food for the fasting period, only calorie-free liquids, including water and herbal tea. I only recommend extended fasting to those who are experienced with and do well on more advanced intermittent fasting protocols.

You may also try an extended partial fast, such as a green juice or bone broth fast first, to prepare for a water fast. You may learn more about extended water fasting in this article, partial fasting here, and how to break and extended fast in this one (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Consume Nutrient-Dense Foods

If you want to achieve brain autophagy and support your brain health, make sure that you consume an anti-inflammatory, brain-supporting diet abundant in nutrient-dense foods. Remove all inflammatory foods, including refined sugar, gluten, refined oils, deep-fried and processed foods, conventional dairy, grain-fed meat and eggs, soda and sugary drinks, and foods that you are sensitive to.

Instead, load up on greens, such as spinach, kale, and chards, vegetables, such as cucumber, celery, and asparagus, low glycemic index fruits, such as lemon, lime, and berries, herbs and spices, including turmeric, ginger, and basil, healthy fats, such as avocados, coconut oil, extra virgin olive oil, and organic butter and ghee, and clean protein, including grass-fed meat, free-range poultry and eggs, and wild-caught fish. To learn more about a nutrient-dense diet, I recommend reading this article as well (59, 60)

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Regular Exercise and Brain Autophagy 

Regular exercise is critical for brain autophagy and brain health. Regular exercise and movement may help to reduce chronic inflammation, decrease stress, uplift your mood, improve memory and learning, and reduce the risk of cognitive decline. I recommend that you exercise at least 20 to 30 minutes 5 times a week and stay active throughout the day. Aim for a mix of cardiovascular exercise, strength and resistance training, and low-impact exercise.

There are many forms of exercise that you can do without leaving your house. High-intensity interval training (HIIT) is great for a mix of cardio and strength work. You may use Zumba or dance videos, try jumping jacks, or get an indoor mini trampoline for cardio.

Try bodyweight exercises, TRX, or kettlebells for strength training. Yoga, pilates, and barre are great low impact exercises that also tone and strengthen. Stay active by stretching regularly, dancing to your favorite song, playing with your kids or pets, gardening, dancing, or if you can, going for a walk outside (60).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Heat Therapy and Brain Autophagy

To support brain autophagy, you may want to consider heat therapy. The stress of the heat urges your body to destroy old and damaged cells and create new and healthy cells through the process of autophagy. Heat shock proteins (HSP) are a group of proteins that your cells produce as a response to exposure to stressful conditions they encounter.

They play an important role in your body’s cellular repair system. They may help to stabilize new proteins and refold damaged proteins. Saunas, UV light therapy, taking hot healing baths, or using a heating pad on sore muscles may be forms of heat therapy (61).

For optimal immune support, brain support and other health benefits, I recommend an infrared sauna by Synergy Science as a great affordable option with safe, deep penetrating, detoxifying, and immune-supporting benefits.

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Cold Therapy 

Along with heat therapy, I recommend that you consider cold therapy as well for increased brain autophagy. In this case, the stress from the cold leads to autophagy, the removal of old and damaged cells and the creation of new and healthy cells. Cold shock proteins or cold shock domain (CSD) is a protein domain of about 70 amino acids.

Cold shock proteins may help your cells to survive under stressful conditions. While heat shock proteins help your cells to survive conditions warmer than optimal, cold shock proteins help survival in lower than optimal temperature. Cold therapy methods include cryotherapy chambers, jumping into a cold pool, or taking a cold shower.

I recommend combining hot and cold therapy. You may want to sit in a sauna then take a cold shower or jump into the pool. An even simpler way is finishing up your warm shower with a cold shower. To learn more about cold therapy and the benefits of cold showers, I recommend this article (61, 62, 63, 64).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Herbs That Enhance Brain Autophagy 

To enhance brain autophagy and protect your brain cells, I recommend autophagy-enhancing herbs, including matcha green tea, ginger, turmeric, resveratrol, citrus bergamot, oregano, sage, rosemary, and quercetin. One of my favorite autophagy-enhancing products is Inflam Defense™. It is a powerful supplement made with turmeric, ginger, boswellia, quercetin, rosemary, and rutin. It protects from oxidative stress, reduces inflammation, and boosts brain autophagy.

Another powerful brain autophagy-enhancing supplement I love is Resveratrol Power. Resveratrol is a potent polyphenol found in the skin of grapes and berries with potent antioxidant and anti-aging benefits. It lowers inflammation, reduces oxidative stress, and protects your brain. To learn more about the top autophagy-enhancing herbs, I recommend this article (65).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Red Light Therapy

Red light therapy (RLT) is a powerful therapeutic technique that may improve brain autophagy. IT has been used for a variety of therapeutic purposes in alternative healing, including wounds, scars, skin issues, inflammation, pain, sleep, and hair growth. It increases cellular energy and antioxidant activity in your body.

If you are looking for a powerful, safe, effective, yet affordable red light therapy option, I recommend Mito Red Light Therapy Device. To learn more about red light therapy, I recommend this article (66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77).

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Hyperbaric Oxygen Therapy

Hyperbaric oxygen therapy is a method that not only supports brain autophagy but has countless health benefits. It has been shown to raise tissue oxygen levels, support new blood vessel growth, increase your body’s defense system, increase stem cells, reduce swelling, and support optimal health.

To learn more about hyperbaric oxygen therapy, I recommend reading this article (78, 79, 80, 81, 82,

brain autophagy, Brain Autophagy: Healing the Toxic Brain

brain autophagy, Brain Autophagy: Healing the Toxic Brain

The Leaky Brain Summit

“Leaky brain” is a brain health issue that often goes undetected and can underlie stress, anxiety, depression, neurological disorders, brain degeneration and autoimmunity.

Caused by various lifestyle factors — infections, stress, trauma, poor diet, environmental toxins — leaky brain is treatable and preventable!

Given that “leaky brain” is not as common a term in our health culture as “leaky gut” has become, I invite you to learn more about this concern, as it may be contributing to your health challenges.

Especially if you want to decrease stress and anxiety, and optimize your brain health.

—>>Learn more about leaky gut, and how to evaluate the health of your brain when you attend this online event!

Often, symptoms of these issues are automatically prescribed pharmaceutical drugs — WITHOUT the identification or treatment of underlying causes.

However, there are data-driven answers and actionable solutions for brain regeneration and neurological health!

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Leaky Brain Summit

Your hosts, Dr. Elena Villanueva and Dr. Ryan Wohlfert, have committed the last 12 months of their lives to searching the globe and interviewing the most qualified experts in leaky brain to give you the most cutting-edge information on this potentially harmful condition.

They’re here to show you evidence-based programs and protocols to understand, identify and address the root causes and symptoms of leaky brain, and the neurochemical and neurodegenerative conditions associated with it.

The Leaky Brain Summit will help you:
● Identify symptoms of leaky brain
● Understand the brain-immune-gut connection
● Reduce inflammation to help heal leaky brain
● Overcome pain, trauma and stress
● Detox and regenerate your brain
● Master your mindset to optimize brain health
● Know which foods to choose or avoid
● Help children avoid mental health disorders
● And more!

You’re not broken. There are answers. We can heal together.  Don’t miss my presentation on “The Food-Leaky Brain Connection,” where I discuss how the food we eat can damage our gut lining and cause inflammation that impacts our brain.  —>>I’ll see you online at The Leaky Brain Summit when you register today!

brain autophagy, Brain Autophagy: Healing the Toxic Brain

P.S. When you register for the Leaky Brain Summit you get immediate access to the 13 Steps to Balancing Your Brain Chemistry eBook where you will learn the best strategies to optimize your neurotransmitter levels to impact your mood, memory and mindset.

brain autophagy, Brain Autophagy: Healing the Toxic Brain

Final Thoughts on Brain Autophagy

Your brain is the center of all your functions and system. It is essential for learning, cognition, memory, thinking, and individual growth. Brain autophagy is a process that allows your brain to regenerate, get rid of old and unhealthy cells, and replace them with new and healthier ones.

It helps your brain to stay healthy and prevent brain degeneration. Follow my top strategies to promote brain autophagy and support your brain function naturally. To learn more about brain health, I invite you to check out my Super Brain Program here

brain autophagy, Brain Autophagy: Healing the Toxic Brain

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50. Aksungar FB, Topkaya AE, Akyildiz M. Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting. Ann Nutr Metab. PMID: 17374948
51. Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio,Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda. Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice. Food and Nutrition Sciences2011, 2, 287-293 Published Online June 2011 Copyright © 2011 SciRes. Link Here
52. Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010;6(6):702-710.
53. Anderson JL, Carlquist JF, Roberts WL, Horne BD, May HT, Schwarz EL, Pasquali M, Nielson R, Kushnir MM, Rockwood AL, Bair TL, Muhlestein JB; Intermountain Heart Collaborative Study Group.. Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk? Am Heart J. 2007 Jan;153(1):67-73. PMID: 17174641
54. Lanzi R, Luzi L, Caumo A, Andreotti AC, Manzoni MF, Malighetti ME, Sereni LP, Pontiroli AE. Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects. Metabolism. 1999 Sep;48(9):1152-6. PubMed PMID: 10484056
55. Ji S, Guan R, Frank SJ, Messina JL. Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. J Biol Chem. 1999 May 7;274(19):13434-42. PMID: 10224108
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  1. I would fast for a whole day, but I am underweight with muscle wasting…what would you suggest? I am looking for ways to reverse muscle wasting..and fasting wouldn’t help there.

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