When Not To Be on a Ketogenic Diet
A ketogenic diet is a very low carbohydrate, moderate protein and high fat based nutrition plan. A ketogenic diet trains the individual’s metabolism to run off of fatty acids or ketone bodies. This is called fat adapted or keto adapted, when the body has adapted to run off of fatty acids/ketones at rest.
This nutrition plan has been shown to improve insulin sensitivity and reduce inflammation. It also improves cellular healing and mitochondrial biogenesis which supports stronger and healthier cells. All of this leads to reduced risk of chronic disease as well as improved muscle development and fat metabolism (1, 2).
Where Ketosis Can Be Extremely Beneficial
There are certain cases, where I typically recommend a ketogenic diet as the research appears to support that ketosis significantly improves the functionality of these individuals.
Overweight or Obese
Neurodegenerative Conditions such as dementia, Alzheimer’s and Parkinson’s
Most Cancers but especially those of the brain, nervous system and blood (leukemia)
Non-Elite athletes or individuals looking for higher mental & physical performance
The final one is the area that I and many others who have pursued a state of ketosis fall into. At this point in my life, I have no chronic diseases, I feel great 99% of the time, but I am always looking to improve my productivity and performance. I have found being in mild-ketosis to be one of the best ways to improve my energy, mental acuity, creativity, physical strength and overall life performance.
When Ketosis Shouldn’t Be the Desired State
There is no one diet that works perfectly for everyone. Ketosis has the potential to benefit everyone, but under unique circumstances it would not be warranted.
Here are a list of special cases where long-term stable ketosis is not appropriate. In some of these cases, short term mild-ketosis can be very beneficial but it is a case by case basis.
Pregnancy and Breast Feeding
Children and Teenagers
Irregular Menstrual Cycles
Poor Thyroid Function
High Level Athletes
Insulin, Leptin and Female Hormones
Carbohydrates play a role in stimulating the release of insulin and insulin works with a hormone called leptin to help govern energy metabolism (3). Leptin is released from fat cells as they enlarge during a meal and its main function is to signal to a part of our brain called the hypothalamus that we are satisfied and no longer need food.
Insulin is known to stimulate leptin synthesis. A ketogenic diet significantly lowers insulin, which also lowers leptin levels (4). Leptin receptors are found in the human ovaries and pre-ovulatory follicles. Lower levels of circulating leptin can negatively affect the reproductive tissue and cause imbalances in key sex hormones in the female body (5).
Low leptin levels send a message to the body that it is in a time of famine, which can cause a stress response. In these cases, reproductive functions are not prioritized (because the body doesn’t believe the environment is conducive to bringing about life).
This is especially true for women who are already lean and are sticking with a strict ketogenic diet. Women, who naturally have higher body fat levels, will have slightly higher leptin levels while women who are very lean will naturally have lower leptin levels.
Science and research tells us that leptin is needed to maintain female hormone levels in their proper range (6). These hormones are critical for menstruation, fertility, lactation and reproduction. If we lose leptin sensitivity from a higher carb, inflammatory diet or if our leptin levels drop too low from prolonged ketosis, it can spell hormonal problems for women.
Pregnancy and Breast Feeding
As babies are developing the mother’s womb it is critical that the body doesn’t experience any sort of threat of food scarcity. During this stage, it is not appropriate to practice lengthy periods of intermittent fasting or attempt to be on a ketogenic diet.
My wife is currently pregnant with twin boys as I am writing this and she consumes roughly 60-80 grams of carbohydrates on a typical basis. So it is still a lower carb diet but not the 50 grams or less that is necessary to be in mild-ketosis.
The best sources of carbohydrates are those that are packed full of antioxidants. I suggest extra berries, yams, sweet potatoes, pumpkin, carrots and beets.
Children and Teenagers
Children are growing and developing so rapidly and major bodily stressors can negatively effect this. Being in a long-term state of ketosis was shown to help reduce seizures in teenagers with epilepsy but 45% of the girls reported menstrual irregularities such as amenorrhea (no menstrual cycle) and delayed puberty (7).
The only time I recommend a full-ketogenic diet is when children have either epilepsy or another seizure based disorder or if they have cancer. Other than that, I encourage parents to give their kids some low-glycemic fruit in the form of berries, granny smith apples, kiwi, grapefruit, etc. as well as root vegetables such as sweet potatoes, pumpkin, carrots and beets.
Irregular Menstrual Cycles
If you are noticing irregular menstrual cycles on a ketogenic diet, than I would consider bumping up your carbs into that 60-80 range and see what happens.
This is especially important if you are doing a lot of high intensity exercise. The combination of low-carb and high intensity exercise in a lean woman can be a set-up for disaster. Doing this can put the body into a chronically stressed mode and wear out the adrenal glands causing poor exercise recovery and fatigue as well as premenstrual symptoms (8).
The adrenal glands are designed to help the body adapt to stressors. They allow us to think sharply, run and jump and make quick decisions. To do this, they play an important role in regulating blood sugar levels in order to make sure we have the sugar in our system for quick and immediate energy. Adrenal fatigue takes place when the body is under chronic stressors the adrenal glands can no longer keep up with the demands (9).
Lean women who are under stress, do high intensity training and are on a ketogenic diet may be creating a state of chronic stress that there system is unable to adapt too. Cycling out of ketosis, reducing your training load and improving rest along with using things like adaptogenic herbs and B vitamins can help you to recover effectively.
Most men can recover from adrenal fatigue much faster than women, because they have a different hormonal system that is easier to get under control. However, if you are a man dealing with adrenal fatigue, it would be a good idea to cycle out of ketosis, get some good rest and using adaptogenic herbs to speed up recovery would be advised before going back into ketosis.
Poor Thyroid Function
The thyroid helps to regulate metabolism and energy levels throughout the body. If you are in adrenal fatigue, it is a natural mechanism for the body to down-regulate thyroid function. One way the body does this is by increasing reverse T3 (rT3) which is an inactive form that competes with active T3 for cell receptor activity (10).
The body does this as an intelligent response because it is trying to conserve resources and put us in a state of hibernation so we can rest and recover effectively. If the body allowed the thyroid to continue to function at a high level while we were already experiencing adrenal fatigue, it would drive us into a deeper stage of adrenal fatigue that could be life threatening.
It is important to note that many people with hypothyroidism do very well with a cyclic ketogenic diet, but if adrenal fatigue is the major mechanism, than it can be harmful. Take time to support the adrenal glands and then try going back into ketosis. I discuss how to do the ketogenic properly for individuals with thyroid issues in this article.
High Level Athletes
If you are a high level athlete that is competing in Cross-Fit, triathlons, iron-man, long-distance runs, soccer, basketball and football than the ketogenic diet may be challenging. When you are working your body at an extremely high level of activity, you need more calories and quick fuel that is immediately available in your muscle and liver.
A ketogenic diet for a high level athlete can be incredible but it is much tougher to follow and the risk of adrenal insult is higher than someone who is doing a smaller load of exercise.
Cyclic Ketosis and Carb-Back Loading
The best way to add back carbs is to boost them up in the evening. The reason for this is that keeping your carbs low throughout the day is the best way to keep your blood sugar stable and prevent cravings. Once you begin eating carbs during the day, you will notice a much greater degree of hunger throughout the day.
Additionally, we naturally have higher cortisol in the morning and cortisol helps to increase blood sugar. At night, cortisol should naturally drop while melatonin rises so we can sleep well. If our blood sugar is too low and we don’t have enough stored sugar (glycogen) in our muscles and liver than our body may perceive a time of famine and drive up stress hormones and blood sugar.
Taking in carbs in the evening helps to keep stress hormones down and also provides sugar to refuel the muscle and liver glycogen stores. This is called carb backloading and you can read more about it here. When the body has full glycogen stores, it is much less likely to perceive a time of famine.
Once your adrenals are reset, you only want to add back carbs on evenings where you did some sort of exercise. The exercise will pull glycogen out of the muscles and liver and we want to replace that so the body doesn’t get worries about the lack of glycogen. On rest days, go low-carb as your stored carbohydrate in your muscle and liver are still full, so your body won’t perceive this as a period of famine.
Dr Jockers Favorite Carbohydrate Sources
I personally will do 2-3 higher carb days (60-100 carbs max) each week on my higher training days. What is really cool is that after fasting for 14-16 hours the next day, I am typically back into mild-ketosis. This process allows me to do very high intensity training while keeping my adrenals and thyroid healthy.
My favorite carb sources include the following:
- Berries: By far the best because they are loaded with anti-oxidants and powerful DNA protecting nutrients such as anthocyanins (blueberries and blackberries) and ellagic acid (strawberries and raspberries).
- Beets: Great prebiotic fiber and loaded with B vitamins. The best food source of trimethylglycine (also called betaine) which is key for protecting our DNA. If beets didn’t have sugar in them, I would suggest we all eat them everyday!
- Carrots: Great prebiotic fiber and beta carotene. Carrots and beets are two of the very best foods for stimulating healthy peristaltic activity in the gut for good bowel movements.
- Sweet Potatoes: Great prebiotic fiber and loaded with beta carotene and tastes great.
- Pumpkin: Just like sweet potato, loaded with prebiotic fibers and beta carotene for a healthy body.
- Raw Honey: Raw honey has bee pollen and propolis within it that have profound immune system benefits. It also has over 100 active enzymes, bioavailable amino acids and B vitamins. If it didn’t have so much sugar, it would be one of my top health foods.
- Grade B Maple Syrup or Coconut Nectar: These are minimally processed sugars from the maple tree and the coconut tree. These natural sugars also have lots of B vitamins and enzymes to support the bodies energy levels.
- Quinoa: This is not technically a grain, but instead it is a starchy seed. Most people tolerate it well and it is loaded with complete protein, minerals and B vitamins.
- Unripe Bananas and Plantains: Green bananas and green plantains are unripe and there fibrous starch has yet to ripen into sugar. This form of starch is called “resistant starch” because the human digestive system cannot form calories from it. Meanwhile, our microbiome can break it down and use it as fuel. These do still contain some level of sugar and digestible carbs so they will increase your blood sugar but not as much as fully ripened bananas and plantains.
- Brown or White Rice: I am not a big fan of rice, but for an occasional carb feeding it can be a good source. While brown rice has significantly more nutrients than white rice, some people have problems with the lectins in the brown rice. White rice is known to be a great prebiotic fiber and dosn’t have the lectin load that brown rice has.
These are all sources that are most often well-tolerated. Grains and legumes are common food sensitivities that cause further adrenal stress on the body. If you feel as though you tolerate beans well, than by all means use those. If you have gas, bloating and inflammation when you consume them (or anything on this list) than I would recommend avoiding it.
Additionally, I would recommend using some of the blood sugar supportive elements in this article to reduce inflammatory spikes in blood sugar when you are carb loading.